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- Publisher Website: 10.1016/0034-5687(94)90107-4
- Scopus: eid_2-s2.0-0028205161
- PMID: 8023022
- WOS: WOS:A1994ND37200007
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Article: Electrical stimulation of pneumotaxic center: Activation of fibers and neurons
Title | Electrical stimulation of pneumotaxic center: Activation of fibers and neurons |
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Authors | |
Keywords | Control of breathing, pneumotaxic center, Mammals, cat Medulla, pons, rhythm generation Rhythm, respiratory, generation |
Issue Date | 1994 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol |
Citation | Respiration Physiology, 1994, v. 96 n. 1, p. 71-82 How to Cite? |
Abstract | Electrical stimulations of the pneumotaxic center can result in a phase-switch from neural inspiration to expiration or the reverse. Terminations of inspiration are also obtained from many loci ventral to the pneumotaxic center. We hypothesized that responses to some stimulations reflect an activation of fibers rather than neurons. Studies were conducted in decerebrate, vagotomized, paralyzed and ventilated cats. Activities of the phrenic and triangularis sterni nerves were recorded. A multibarreled pipette was inserted into the rostral pons. Electrical stimulation was delivered through two barrels; another contained kainic acid to destroy neurons. The threshold current for producing inspiratory termination was not altered in most regions following the injections of kainic acid. However, stimulation of neurons did appear to underlie the premature onset of phrenic activity. In addition, neurons in medial pontile regions regulate triangularis sterni activity. We conclude that some functions ascribed to the pneumotaxic center are, in fact, subserved by neurons in other regions of the central nervous system. |
Persistent Identifier | http://hdl.handle.net/10722/171606 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fung, ML | en_US |
dc.contributor.author | St John, WM | en_US |
dc.date.accessioned | 2012-10-30T06:15:56Z | - |
dc.date.available | 2012-10-30T06:15:56Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Respiration Physiology, 1994, v. 96 n. 1, p. 71-82 | en_US |
dc.identifier.issn | 0034-5687 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171606 | - |
dc.description.abstract | Electrical stimulations of the pneumotaxic center can result in a phase-switch from neural inspiration to expiration or the reverse. Terminations of inspiration are also obtained from many loci ventral to the pneumotaxic center. We hypothesized that responses to some stimulations reflect an activation of fibers rather than neurons. Studies were conducted in decerebrate, vagotomized, paralyzed and ventilated cats. Activities of the phrenic and triangularis sterni nerves were recorded. A multibarreled pipette was inserted into the rostral pons. Electrical stimulation was delivered through two barrels; another contained kainic acid to destroy neurons. The threshold current for producing inspiratory termination was not altered in most regions following the injections of kainic acid. However, stimulation of neurons did appear to underlie the premature onset of phrenic activity. In addition, neurons in medial pontile regions regulate triangularis sterni activity. We conclude that some functions ascribed to the pneumotaxic center are, in fact, subserved by neurons in other regions of the central nervous system. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol | en_US |
dc.relation.ispartof | Respiration Physiology | en_US |
dc.subject | Control of breathing, pneumotaxic center, Mammals, cat | - |
dc.subject | Medulla, pons, rhythm generation | - |
dc.subject | Rhythm, respiratory, generation | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cats | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Kainic Acid - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Medulla Oblongata - Physiology | en_US |
dc.subject.mesh | Microinjections | en_US |
dc.subject.mesh | Nerve Fibers - Physiology | en_US |
dc.subject.mesh | Neurons - Physiology | en_US |
dc.subject.mesh | Phrenic Nerve - Physiology | en_US |
dc.subject.mesh | Pons - Physiology | en_US |
dc.subject.mesh | Respiration - Drug Effects - Physiology | en_US |
dc.title | Electrical stimulation of pneumotaxic center: Activation of fibers and neurons | en_US |
dc.type | Article | en_US |
dc.identifier.email | Fung, ML:fungml@hkucc.hku.hk | en_US |
dc.identifier.authority | Fung, ML=rp00433 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0034-5687(94)90107-4 | en_US |
dc.identifier.pmid | 8023022 | - |
dc.identifier.scopus | eid_2-s2.0-0028205161 | en_US |
dc.identifier.volume | 96 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 71 | en_US |
dc.identifier.epage | 82 | en_US |
dc.identifier.isi | WOS:A1994ND37200007 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Fung, ML=7101955092 | en_US |
dc.identifier.scopusauthorid | St John, WM=36831054200 | en_US |
dc.identifier.issnl | 0034-5687 | - |