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- Publisher Website: 10.1016/S0197-4580(02)00068-4
- Scopus: eid_2-s2.0-0037213685
- PMID: 12493565
- WOS: WOS:000180458000019
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Article: Alteration of nitric oxide synthase activity in young and aged apolipoprotein E-deficient mice
Title | Alteration of nitric oxide synthase activity in young and aged apolipoprotein E-deficient mice |
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Authors | |
Keywords | Aging Alzheimer's disease Apolipoprotein E Beta-amyloid Cholinergic Cognitive impairments Cortex Hippocampus Inducible nitric oxide synthase Microglia Neuronal nitric oxide synthase Neurotoxicity Nitric oxide Oxidative stress Transgenic mice |
Issue Date | 2003 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging |
Citation | Neurobiology Of Aging, 2003, v. 24 n. 1, p. 187-190 How to Cite? |
Abstract | Impairments in cognitive performance have been observed in aged apolipoprotein E (apoE)-deficient mice, and apoE ε4 allele is a risk factor in Alzheimer's disease (AD). The absence of apoE correlates with diminished antioxidative capacity in animals, and elevated cerebral oxidative stress has been observed in AD individuals carrying the ε4 alleles. Nitric oxide (NO) is a neurosignaling molecule that has significant roles in cognition. NO has also been implicated in neurodegenerative diseases due to its oxidative properties. The current study examined the possible relationship between apoE and nitric oxide synthase (NOS) by comparing hippocampal and cortical NOS activities in wild-type and apoE-knockout mice. Our results showed that apoE deficiency had no effect on NOS activity in these animals; however, aged animals uniformly exhibited significantly higher NOS activity levels. These findings suggest that increased NOS activity may contribute to cognitive impairments in aged wild-type and apoE-knockout mice due to excess accumulation of oxidative damages in areas involved in learning and memory. © 2002 Elsevier Science Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/171915 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.488 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Law, A | en_US |
dc.contributor.author | Gauthier, S | en_US |
dc.contributor.author | Quirion, R | en_US |
dc.date.accessioned | 2012-10-30T06:18:24Z | - |
dc.date.available | 2012-10-30T06:18:24Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Neurobiology Of Aging, 2003, v. 24 n. 1, p. 187-190 | en_US |
dc.identifier.issn | 0197-4580 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171915 | - |
dc.description.abstract | Impairments in cognitive performance have been observed in aged apolipoprotein E (apoE)-deficient mice, and apoE ε4 allele is a risk factor in Alzheimer's disease (AD). The absence of apoE correlates with diminished antioxidative capacity in animals, and elevated cerebral oxidative stress has been observed in AD individuals carrying the ε4 alleles. Nitric oxide (NO) is a neurosignaling molecule that has significant roles in cognition. NO has also been implicated in neurodegenerative diseases due to its oxidative properties. The current study examined the possible relationship between apoE and nitric oxide synthase (NOS) by comparing hippocampal and cortical NOS activities in wild-type and apoE-knockout mice. Our results showed that apoE deficiency had no effect on NOS activity in these animals; however, aged animals uniformly exhibited significantly higher NOS activity levels. These findings suggest that increased NOS activity may contribute to cognitive impairments in aged wild-type and apoE-knockout mice due to excess accumulation of oxidative damages in areas involved in learning and memory. © 2002 Elsevier Science Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging | en_US |
dc.relation.ispartof | Neurobiology of Aging | en_US |
dc.subject | Aging | - |
dc.subject | Alzheimer's disease | - |
dc.subject | Apolipoprotein E | - |
dc.subject | Beta-amyloid | - |
dc.subject | Cholinergic | - |
dc.subject | Cognitive impairments | - |
dc.subject | Cortex | - |
dc.subject | Hippocampus | - |
dc.subject | Inducible nitric oxide synthase | - |
dc.subject | Microglia | - |
dc.subject | Neuronal nitric oxide synthase | - |
dc.subject | Neurotoxicity | - |
dc.subject | Nitric oxide | - |
dc.subject | Oxidative stress | - |
dc.subject | Transgenic mice | - |
dc.subject.mesh | Aging - Metabolism | en_US |
dc.subject.mesh | Alzheimer Disease - Enzymology - Genetics | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Apolipoproteins E - Deficiency - Genetics - Metabolism | en_US |
dc.subject.mesh | Cerebral Cortex - Enzymology | en_US |
dc.subject.mesh | Hippocampus - Enzymology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, Inbred C57bl - Metabolism | en_US |
dc.subject.mesh | Mice, Knockout | en_US |
dc.subject.mesh | Nitric Oxide Synthase - Analysis - Metabolism | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.title | Alteration of nitric oxide synthase activity in young and aged apolipoprotein E-deficient mice | en_US |
dc.type | Article | en_US |
dc.identifier.email | Law, A:acklaw@hku.hk | en_US |
dc.identifier.authority | Law, A=rp00262 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0197-4580(02)00068-4 | en_US |
dc.identifier.pmid | 12493565 | - |
dc.identifier.scopus | eid_2-s2.0-0037213685 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0037213685&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 187 | en_US |
dc.identifier.epage | 190 | en_US |
dc.identifier.isi | WOS:000180458000019 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Law, A=26323772800 | en_US |
dc.identifier.scopusauthorid | Gauthier, S=7102604782 | en_US |
dc.identifier.scopusauthorid | Quirion, R=7202416940 | en_US |
dc.identifier.issnl | 0197-4580 | - |