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- Publisher Website: 10.4049/jimmunol.177.10.6730
- Scopus: eid_2-s2.0-33750825269
- PMID: 17082586
- WOS: WOS:000242009700021
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Article: Human bone marrow: A reservoir for "enhanced effector memory" CD8 + T cells with potent recall function
Title | Human bone marrow: A reservoir for "enhanced effector memory" CD8 + T cells with potent recall function |
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Authors | |
Issue Date | 2006 |
Publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org |
Citation | Journal Of Immunology, 2006, v. 177 n. 10, p. 6730-6737 How to Cite? |
Abstract | The role of human bone marrow (BM) CD8 + T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8 + T cell population (T EM) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived T EM differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM T EM have low levels of resting perform and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the T EM subset in PB, BM CD8 + T EM cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-spccific T EM with great therapeutic potential in vaccine development. Copyright © 2006 by The American Association of Immunologists, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/172427 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.558 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, X | en_US |
dc.contributor.author | Dong, H | en_US |
dc.contributor.author | Lin, W | en_US |
dc.contributor.author | Voss, S | en_US |
dc.contributor.author | Hinkley, L | en_US |
dc.contributor.author | Westergren, M | en_US |
dc.contributor.author | Tian, G | en_US |
dc.contributor.author | Berry, D | en_US |
dc.contributor.author | Lewellen, D | en_US |
dc.contributor.author | Vile, RG | en_US |
dc.contributor.author | Chen, L | en_US |
dc.contributor.author | Farber, DL | en_US |
dc.contributor.author | Strome, SE | en_US |
dc.date.accessioned | 2012-10-30T06:22:28Z | - |
dc.date.available | 2012-10-30T06:22:28Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Journal Of Immunology, 2006, v. 177 n. 10, p. 6730-6737 | en_US |
dc.identifier.issn | 0022-1767 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172427 | - |
dc.description.abstract | The role of human bone marrow (BM) CD8 + T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8 + T cell population (T EM) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived T EM differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM T EM have low levels of resting perform and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the T EM subset in PB, BM CD8 + T EM cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-spccific T EM with great therapeutic potential in vaccine development. Copyright © 2006 by The American Association of Immunologists, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org | en_US |
dc.relation.ispartof | Journal of Immunology | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Antigens, Viral - Immunology | en_US |
dc.subject.mesh | Bone Marrow Cells - Cytology - Immunology - Metabolism - Virology | en_US |
dc.subject.mesh | Cd8-Positive T-Lymphocytes - Cytology - Immunology - Metabolism - Virology | en_US |
dc.subject.mesh | Cytomegalovirus - Immunology | en_US |
dc.subject.mesh | Cytotoxicity, Immunologic | en_US |
dc.subject.mesh | Epitopes, T-Lymphocyte - Immunology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Herpesvirus 4, Human - Immunology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunologic Memory | en_US |
dc.subject.mesh | Immunophenotyping | en_US |
dc.subject.mesh | Leukocytes, Mononuclear - Cytology - Immunology | en_US |
dc.subject.mesh | Lymphocyte Count | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Receptors, Chemokine - Biosynthesis | en_US |
dc.title | Human bone marrow: A reservoir for "enhanced effector memory" CD8 + T cells with potent recall function | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tian, G: gltian@hku.hk | en_US |
dc.identifier.authority | Tian, G=rp00789 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.4049/jimmunol.177.10.6730 | - |
dc.identifier.pmid | 17082586 | - |
dc.identifier.scopus | eid_2-s2.0-33750825269 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33750825269&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 177 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.spage | 6730 | en_US |
dc.identifier.epage | 6737 | en_US |
dc.identifier.isi | WOS:000242009700021 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zhang, X=8281363400 | en_US |
dc.identifier.scopusauthorid | Dong, H=7402334840 | en_US |
dc.identifier.scopusauthorid | Lin, W=36068291300 | en_US |
dc.identifier.scopusauthorid | Voss, S=26028199600 | en_US |
dc.identifier.scopusauthorid | Hinkley, L=6602924820 | en_US |
dc.identifier.scopusauthorid | Westergren, M=15058381100 | en_US |
dc.identifier.scopusauthorid | Tian, G=25621549400 | en_US |
dc.identifier.scopusauthorid | Berry, D=55065696800 | en_US |
dc.identifier.scopusauthorid | Lewellen, D=15057757700 | en_US |
dc.identifier.scopusauthorid | Vile, RG=7006170387 | en_US |
dc.identifier.scopusauthorid | Chen, L=7409444112 | en_US |
dc.identifier.scopusauthorid | Farber, DL=35576751000 | en_US |
dc.identifier.scopusauthorid | Strome, SE=7004882323 | en_US |
dc.identifier.issnl | 0022-1767 | - |