Estrogen and progesterone receptors in normal cervix and primary cervical carcinoma

Abstract

Estrogen and progesterone receptor levels (ER and PR) were measured in 21 specimens of cervical carcinoma and in 17 normal cervix by monoclonal enzyme immunoassay (ER-EIA and PR-EIA). In normal cervix, 88.2% of specimens were ER-positive (more than 15 fmol/mg protein), 74.5% were PR-positive (more than 15 fmol/mg protein) and 74.5% were both ER and PR-positive. In cervical cancer, 66.7% of malignancies were ER-positive, 42.9% were PR-positive and 38.1% were both ER and PR-positive. There was no significant difference in ER status between the normal cervix and cervical cancer (P > 0.05), but PR status and levels in normal cervix were significantly higher than those in cervical carcinoma (P < 0.05). ER levels in squamous cell carcinoma was not correlated to the tumor stage, histologic grade and menopausal status. PR levels in premenopausal patients with squamous cell carcinoma were significantly higher than those in postmenopausal patients (P < 0.01). Adenocarcinoma of the cervix contained significantly more ER and PR than squamous cell carcinoma (P < 0.01, P < 0.05). In addition, serum E2 level was also assayed in 21 patients with cervical cancer. There was significant difference in E2 levels between the premenopausal and postmenopausal patients (P < 0.01). Patients were stratified according to E2 levels, a significant difference in PR level and in ratio of PR/ER was noted (P < 0.05, P < 0.01).

采用單克隆酶聯免疫測定法，檢測了２１例宮頸癌（宮頸癌組）和１７例正常宮頸肌層纖維組織（正常組）的雌、孕激素受體水平。結果：正常組雌激素受體（ＥＲ）的陽性率為８８．２％，孕激素受體（ＰＲ）的陽性率為７４．５％，ＥＲ和ＰＲ均陽性者占７４．５％。宮頸癌組ＥＲ陽性率為６６．７％，ＰＲ陽性率為４２．９％，ＥＲ和ＰＲ均陽性者占３８．１％。兩組ＥＲ狀態和水平比較，差異無顯著意義（Ｐ＞０．０５），但宮頸癌組的Ｐｋ陽性率和ＰＲ水平均明顯低于正常組（Ｐ＜０．０５）。宮頸癌組織的ＥＲ和ＰＲ水平與腫瘤分期，組織學分級之間，差異無顯著意義（Ｐ＞０．０５）。絕經前宮頸癌組織ＰＲ水平較絕經后明顯升高。宮頸腺癌組織ＥＲ和ＰＲ水平均明顯高于宮頸鱗癌。宮頸癌患者按血清雌二醇水平高低分組，ＰＲ水平和ＰＲ／ＥＲ比值比較，差異均有顯著意義。