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- Publisher Website: 10.1002/1097-0223(200008)20:8<673::AID-PD880>3.0.CO;2-5
- Scopus: eid_2-s2.0-0033880564
- PMID: 10951481
- WOS: WOS:000088688700013
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Article: The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestation
Title | The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestation |
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Authors | |
Keywords | Down syndrome First trimester Free β-hCG Nuchal translucency PAPP-A Prenatal screening |
Issue Date | 2000 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 |
Citation | Prenatal Diagnosis, 2000, v. 20 n. 8, p. 673-675 How to Cite? |
Abstract | In a study of 2923 normal pregnancies and 203 pregnancies affected by trisomy 21 we have shown a significant difference in the median MoM of the markers: fetal nuchal translucency, maternal serum free β-hCG and PAPP-A in the presence of a female fetus compared with a male fetus. For maternal serum free β-hCG levels are higher by 15% if the fetus is chromosomally normal and by 11% if the fetus has trisomy 21. For maternal serum PAPP-A the levels in chromosomally normal fetuses are 10% higher in the presence of a female fetus and 13%, higher if the fetus has trisomy 21. In contrast, fetal nuchal translucency is 3-4% lower in both chromosomally normal and trisomy 21 female fetuses. The consequence of such changes when screening for trisomy 21 will be a reduction in the detection rate in female fetuses by a factor of 1-2%. Correction of risk algorithms for fetal sex, however, is probably not feasible, since ultrasound detection of fetal sex is only 70-90%, accurate in the 10-14 week period. Copyright (C) 2000 John Wiley and Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/173241 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.986 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Spencer, K | en_US |
dc.contributor.author | Ong, CYT | en_US |
dc.contributor.author | Liao, AWJ | en_US |
dc.contributor.author | Papademetriou, D | en_US |
dc.contributor.author | Nicolaides, KH | en_US |
dc.date.accessioned | 2012-10-30T06:28:44Z | - |
dc.date.available | 2012-10-30T06:28:44Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Prenatal Diagnosis, 2000, v. 20 n. 8, p. 673-675 | en_US |
dc.identifier.issn | 0197-3851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173241 | - |
dc.description.abstract | In a study of 2923 normal pregnancies and 203 pregnancies affected by trisomy 21 we have shown a significant difference in the median MoM of the markers: fetal nuchal translucency, maternal serum free β-hCG and PAPP-A in the presence of a female fetus compared with a male fetus. For maternal serum free β-hCG levels are higher by 15% if the fetus is chromosomally normal and by 11% if the fetus has trisomy 21. For maternal serum PAPP-A the levels in chromosomally normal fetuses are 10% higher in the presence of a female fetus and 13%, higher if the fetus has trisomy 21. In contrast, fetal nuchal translucency is 3-4% lower in both chromosomally normal and trisomy 21 female fetuses. The consequence of such changes when screening for trisomy 21 will be a reduction in the detection rate in female fetuses by a factor of 1-2%. Correction of risk algorithms for fetal sex, however, is probably not feasible, since ultrasound detection of fetal sex is only 70-90%, accurate in the 10-14 week period. Copyright (C) 2000 John Wiley and Sons, Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_US |
dc.relation.ispartof | Prenatal Diagnosis | en_US |
dc.rights | Prenatal Diagnosis. Copyright © John Wiley & Sons Ltd. | - |
dc.subject | Down syndrome | - |
dc.subject | First trimester | - |
dc.subject | Free β-hCG | - |
dc.subject | Nuchal translucency | - |
dc.subject | PAPP-A | - |
dc.subject | Prenatal screening | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Chorionic Gonadotropin, Beta Subunit, Human - Blood | en_US |
dc.subject.mesh | Down Syndrome - Blood - Diagnosis - Ultrasonography | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gestational Age | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Neck - Embryology - Ultrasonography | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy-Associated Plasma Protein-A - Analysis | en_US |
dc.subject.mesh | Prenatal Diagnosis | en_US |
dc.subject.mesh | Sex Factors | en_US |
dc.subject.mesh | Ultrasonography, Prenatal | en_US |
dc.title | The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ong, CYT:cytong@hkucc.hku.hk | en_US |
dc.identifier.authority | Ong, CYT=rp00482 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/1097-0223(200008)20:8<673::AID-PD880>3.0.CO;2-5 | en_US |
dc.identifier.pmid | 10951481 | - |
dc.identifier.scopus | eid_2-s2.0-0033880564 | en_US |
dc.identifier.hkuros | 79013 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033880564&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 673 | en_US |
dc.identifier.epage | 675 | en_US |
dc.identifier.isi | WOS:000088688700013 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Spencer, K=7202053140 | en_US |
dc.identifier.scopusauthorid | Ong, CYT=7401968192 | en_US |
dc.identifier.scopusauthorid | Liao, AWJ=7006509060 | en_US |
dc.identifier.scopusauthorid | Papademetriou, D=23103835500 | en_US |
dc.identifier.scopusauthorid | Nicolaides, KH=7203078780 | en_US |
dc.identifier.issnl | 0197-3851 | - |