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- Publisher Website: 10.1111/j.1365-2559.2007.02804.x
- Scopus: eid_2-s2.0-34548861493
- PMID: 17880529
- WOS: WOS:000249661900006
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Article: p63 expression in ovarian tumours: A marker for Brenner tumours but not transitional cell carcinomas
Title | p63 expression in ovarian tumours: A marker for Brenner tumours but not transitional cell carcinomas |
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Authors | |
Keywords | Brenner tumour Ovarian tumours p63 Transitional cell carcinoma |
Issue Date | 2007 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS |
Citation | Histopathology, 2007, v. 51 n. 4, p. 477-483 How to Cite? |
Abstract | Aims: To investigate p63 expression in ovarian neoplasms. Methods and results: Immunohistochemistry using an antibody that detects all p63 isoforms was performed on 103 primary ovarian neoplasms of different histological types. Diffuse nuclear immunoreactivity of p63 was demonstrated in the 17 benign and five borderline Brenner tumours. Only one of the six malignant Brenner tumours displayed p63 expression. p63 immunoreactivity was absent in all the ovarian transitional cell carcinomas (TCC), but was demonstrated extensively in TCCs of the urinary bladder. Besides focal p63 expression in epidermal basal cells of immature and mature teratomas, all other ovarian lesions were devoid of p63 expression. p63 expression was also demonstrated in cervical transitional cell metaplasia and Walthard cell nests of fallopian tubes. Conclusions: Expression of p63 protein is apparently cell lineage specific and in ovarian neoplasms is confined to benign and borderline Brenner tumours. The loss of expression in malignant Benner tumours suggests a role for p63 in Brenner carcinogenesis. The distinct patterns of p63 expression in TCCs in the ovary and urinary bladder may help in their differential diagnosis. © 2007 The Authors. |
Persistent Identifier | http://hdl.handle.net/10722/173328 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.392 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Liao, XY | en_HK |
dc.contributor.author | Xue, WC | en_HK |
dc.contributor.author | Shen, DH | en_HK |
dc.contributor.author | Ngan, HYS | en_HK |
dc.contributor.author | Siu, MK | en_HK |
dc.contributor.author | Cheung, AN | en_HK |
dc.date.accessioned | 2012-10-30T06:29:22Z | - |
dc.date.available | 2012-10-30T06:29:22Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | Histopathology, 2007, v. 51 n. 4, p. 477-483 | en_HK |
dc.identifier.issn | 0309-0167 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/173328 | - |
dc.description.abstract | Aims: To investigate p63 expression in ovarian neoplasms. Methods and results: Immunohistochemistry using an antibody that detects all p63 isoforms was performed on 103 primary ovarian neoplasms of different histological types. Diffuse nuclear immunoreactivity of p63 was demonstrated in the 17 benign and five borderline Brenner tumours. Only one of the six malignant Brenner tumours displayed p63 expression. p63 immunoreactivity was absent in all the ovarian transitional cell carcinomas (TCC), but was demonstrated extensively in TCCs of the urinary bladder. Besides focal p63 expression in epidermal basal cells of immature and mature teratomas, all other ovarian lesions were devoid of p63 expression. p63 expression was also demonstrated in cervical transitional cell metaplasia and Walthard cell nests of fallopian tubes. Conclusions: Expression of p63 protein is apparently cell lineage specific and in ovarian neoplasms is confined to benign and borderline Brenner tumours. The loss of expression in malignant Benner tumours suggests a role for p63 in Brenner carcinogenesis. The distinct patterns of p63 expression in TCCs in the ovary and urinary bladder may help in their differential diagnosis. © 2007 The Authors. | en_HK |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS | en_HK |
dc.relation.ispartof | Histopathology | en_HK |
dc.subject | Brenner tumour | en_HK |
dc.subject | Ovarian tumours | en_HK |
dc.subject | p63 | en_HK |
dc.subject | Transitional cell carcinoma | en_HK |
dc.subject.mesh | Brenner Tumor - Diagnosis - Metabolism - Pathology | en_US |
dc.subject.mesh | Carcinoma, Transitional Cell - Diagnosis - Metabolism - Pathology | en_US |
dc.subject.mesh | Diagnosis, Differential | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Membrane Proteins - Genetics - Metabolism | en_US |
dc.subject.mesh | Ovarian Neoplasms - Diagnosis - Metabolism - Pathology | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Tumor Markers, Biological - Metabolism | en_US |
dc.title | p63 expression in ovarian tumours: A marker for Brenner tumours but not transitional cell carcinomas | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ngan, HYS: hysngan@hkucc.hku.hk | en_HK |
dc.identifier.email | Siu, MK: mkysiu@hkucc.hku.hk | en_HK |
dc.identifier.email | Cheung, AN: anycheun@hkucc.hku.hk | en_HK |
dc.identifier.authority | Ngan, HYS=rp00346 | en_HK |
dc.identifier.authority | Siu, MK=rp00275 | en_HK |
dc.identifier.authority | Cheung, AN=rp00542 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1365-2559.2007.02804.x | en_HK |
dc.identifier.pmid | 17880529 | - |
dc.identifier.scopus | eid_2-s2.0-34548861493 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-34548861493&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 51 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 477 | en_HK |
dc.identifier.epage | 483 | en_HK |
dc.identifier.isi | WOS:000249661900006 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Liao, XY=7202134156 | en_HK |
dc.identifier.scopusauthorid | Xue, WC=26640823700 | en_HK |
dc.identifier.scopusauthorid | Shen, DH=7401738584 | en_HK |
dc.identifier.scopusauthorid | Ngan, HYS=34571944100 | en_HK |
dc.identifier.scopusauthorid | Siu, MK=24924018400 | en_HK |
dc.identifier.scopusauthorid | Cheung, AN=54927484100 | en_HK |
dc.identifier.citeulike | 1680966 | - |
dc.identifier.issnl | 0309-0167 | - |