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- Publisher Website: 10.1097/00005344-199322008-00061
- Scopus: eid_2-s2.0-0027764530
- PMID: 7509952
- WOS: WOS:A1993MN02800061
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Conference Paper: Endothelins and membrane potential of vascular smooth muscle of the canine coronary artery
Title | Endothelins and membrane potential of vascular smooth muscle of the canine coronary artery |
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Authors | |
Keywords | BQ123 EDHF EDRF ET(A) receptor ET(B) receptor |
Issue Date | 1993 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ |
Citation | Journal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S229-S231 How to Cite? |
Abstract | We investigated the effects of endothelins on the membrane potential of vascular smooth-muscle cells of canine coronary artery, using glass microelectrodes. In tissues with endothelium, endothelin-1 (ET-1), from 10- 12 to 10-9 M, did not alter the membrane potential. Higher concentrations of the peptide produced sustained depolarization without detectable hyperpolarization. Endothelin-3 (ET-3, 10-11 to 10-8 M) did not produce significant membrane hyperpolarization in tissues with endothelium. Prostaglandin F(2α) (10-5 M) depolarized the cell membrane by about 6 mV. ET-1 (10-9 M) did not evoke detectable hyperpolarization in the presence of prostaglandin F(2α). In tissues incubated with BQ123 (10-6 M, a selective ET(A)-receptor antagonist), which attenuated the depolarization evoked by ET- 1, both isopeptides did not produce detectable hyperpolarization. These findings suggest that ET-1 and ET-3 do not evoke the release of endothelium- derived hyperpolarizing factor in the canine coronary artery. |
Persistent Identifier | http://hdl.handle.net/10722/173519 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nakashima, M | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:32:28Z | - |
dc.date.available | 2012-10-30T06:32:28Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 1993, v. 22 SUPPL. 8, p. S229-S231 | en_US |
dc.identifier.issn | 0160-2446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173519 | - |
dc.description.abstract | We investigated the effects of endothelins on the membrane potential of vascular smooth-muscle cells of canine coronary artery, using glass microelectrodes. In tissues with endothelium, endothelin-1 (ET-1), from 10- 12 to 10-9 M, did not alter the membrane potential. Higher concentrations of the peptide produced sustained depolarization without detectable hyperpolarization. Endothelin-3 (ET-3, 10-11 to 10-8 M) did not produce significant membrane hyperpolarization in tissues with endothelium. Prostaglandin F(2α) (10-5 M) depolarized the cell membrane by about 6 mV. ET-1 (10-9 M) did not evoke detectable hyperpolarization in the presence of prostaglandin F(2α). In tissues incubated with BQ123 (10-6 M, a selective ET(A)-receptor antagonist), which attenuated the depolarization evoked by ET- 1, both isopeptides did not produce detectable hyperpolarization. These findings suggest that ET-1 and ET-3 do not evoke the release of endothelium- derived hyperpolarizing factor in the canine coronary artery. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_US |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_US |
dc.subject | BQ123 | - |
dc.subject | EDHF | - |
dc.subject | EDRF | - |
dc.subject | ET(A) receptor | - |
dc.subject | ET(B) receptor | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Factors - Pharmacology | en_US |
dc.subject.mesh | Coronary Vessels - Drug Effects | en_US |
dc.subject.mesh | Dinoprost - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelins - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Membrane Potentials - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects | en_US |
dc.subject.mesh | Peptides, Cyclic - Pharmacology | en_US |
dc.subject.mesh | Receptors, Endothelin - Antagonists & Inhibitors | en_US |
dc.title | Endothelins and membrane potential of vascular smooth muscle of the canine coronary artery | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00005344-199322008-00061 | - |
dc.identifier.pmid | 7509952 | - |
dc.identifier.scopus | eid_2-s2.0-0027764530 | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | SUPPL. 8 | en_US |
dc.identifier.spage | S229 | en_US |
dc.identifier.epage | S231 | en_US |
dc.identifier.isi | WOS:A1993MN02800061 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Nakashima, M=35599797500 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0160-2446 | - |