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- Publisher Website: 10.1111/j.1600-0447.1994.tb01501.x
- Scopus: eid_2-s2.0-0028047740
- PMID: 8178665
- WOS: WOS:A1994MV75400011
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Article: A typological model of schizophrenia based on age at onset, sex and familial morbidity
Title | A typological model of schizophrenia based on age at onset, sex and familial morbidity |
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Authors | |
Keywords | age at onset familial loading Key Word schizophrenia sex difference |
Issue Date | 1994 |
Publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACP |
Citation | Acta Psychiatrica Scandinavica, 1994, v. 89 n. 2, p. 135-141 How to Cite? |
Abstract | We investigated the age at onset distributions of schizophrenia in men and women and the relationship of age at onset and sex to the familial rates of schizophrenia and manic-depression in data from a Swedish family study of 270 schizophrenic probands. On the logarithmic scale, the age at onset distribution of schizophrenia in both male and female relatives was bimodal, suggesting that broadly defined schizophrenia may be a mixture of 2 (probably related) disorders. The risk of schizophrenia in relatives decreased as a function of the age at onset of the proband, irrespective of the sex of the proband or relative. In contrast, the risk of manic-depression was significantly higher in relatives of female probands with an age at onset in the twenties than in relatives of female probands with earlier or later onset, or in relatives of male probands. This suggests a third disorder related to affective psychosis, with an intermediate age at onset and female preponderance. |
Persistent Identifier | http://hdl.handle.net/10722/175693 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 2.615 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sham, PC | en_US |
dc.contributor.author | Maclean, CJ | en_US |
dc.contributor.author | Kendler, KS | en_US |
dc.date.accessioned | 2012-11-26T09:00:32Z | - |
dc.date.available | 2012-11-26T09:00:32Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Acta Psychiatrica Scandinavica, 1994, v. 89 n. 2, p. 135-141 | en_US |
dc.identifier.issn | 0001-690X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175693 | - |
dc.description.abstract | We investigated the age at onset distributions of schizophrenia in men and women and the relationship of age at onset and sex to the familial rates of schizophrenia and manic-depression in data from a Swedish family study of 270 schizophrenic probands. On the logarithmic scale, the age at onset distribution of schizophrenia in both male and female relatives was bimodal, suggesting that broadly defined schizophrenia may be a mixture of 2 (probably related) disorders. The risk of schizophrenia in relatives decreased as a function of the age at onset of the proband, irrespective of the sex of the proband or relative. In contrast, the risk of manic-depression was significantly higher in relatives of female probands with an age at onset in the twenties than in relatives of female probands with earlier or later onset, or in relatives of male probands. This suggests a third disorder related to affective psychosis, with an intermediate age at onset and female preponderance. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ACP | en_US |
dc.relation.ispartof | Acta Psychiatrica Scandinavica | en_US |
dc.subject | age at onset | - |
dc.subject | familial loading | - |
dc.subject | Key Word | - |
dc.subject | schizophrenia | - |
dc.subject | sex difference | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Bipolar Disorder - Diagnosis - Epidemiology - Genetics - Psychology | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Models, Genetic | en_US |
dc.subject.mesh | Phenotype | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Schizophrenia - Diagnosis - Epidemiology - Genetics | en_US |
dc.subject.mesh | Schizophrenic Psychology | en_US |
dc.subject.mesh | Sex Factors | en_US |
dc.subject.mesh | Sweden - Epidemiology | en_US |
dc.title | A typological model of schizophrenia based on age at onset, sex and familial morbidity | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, PC=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1600-0447.1994.tb01501.x | - |
dc.identifier.pmid | 8178665 | - |
dc.identifier.scopus | eid_2-s2.0-0028047740 | en_US |
dc.identifier.volume | 89 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 135 | en_US |
dc.identifier.epage | 141 | en_US |
dc.identifier.isi | WOS:A1994MV75400011 | - |
dc.publisher.place | Denmark | en_US |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_US |
dc.identifier.scopusauthorid | MacLean, CJ=7102972772 | en_US |
dc.identifier.scopusauthorid | Kendler, KS=35396760800 | en_US |
dc.identifier.issnl | 0001-690X | - |