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Article: 5-HT(2A) receptor and bipolar affective disorder: Association studies in affected patients

Title5-HT(2A) receptor and bipolar affective disorder: Association studies in affected patients
Authors
Arranz, MJErdmann, JKirov, GRietschel, MSodhi, MAlbus, MBall, DMaier, WDavies, NFranzek, EAbusaad, IWeigelt, BMurray, RShimronAbarbanell, DKerwin, RPropping, PSham, PNöthen, MMCollier, DA
Keywords5-HT(2A) receptor gene
bipolar affective disorder
single strand conformation polymorphism
Issue Date1997
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1997, v. 224 n. 2, p. 95-98 How to Cite?
DOI: http://dx.doi.org/10.1016/S0304-3940(97)13456-5
AbstractThe aim of this study was to investigate the possible involvement of genetic variation in serotonin receptors in the aetiology of bipolar affective disorder. The 5-HT(2A) receptor gene was systematically screened for genetic variants by single strand conformation polymorphism (SSCP) methods in subjects with bipolar affective disorder. Four polymorphisms (two structural changes, Thr25Asn and His452Tyr, and two silent polymorphisms, 102-T/C and 516-C/T) which had previously been found in patients with schizophrenia and control subjects were detected. No novel polymorphisms were found in patients with bipolar affective disorder. These polymorphisms were genotyped in a sample of 129 patients and 252 controls of German origin and 176 patients and 182 controls of British origin. No strong associations were found between any of these polymorphisms and bipolar affective disorder. Genetic variation at the 5-HT(2A) receptor gene does not play a major role in the pathogenesis of the disorder.
Persistent Identifierhttp://hdl.handle.net/10722/175768
ISSN
0304-3940
2021 Impact Factor: 3.197
2020 SCImago Journal Rankings: 0.944
ISI Accession Number ID
WOS:A1997WP22600006
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorArranz, MJen_US
dc.contributor.authorErdmann, Jen_US
dc.contributor.authorKirov, Gen_US
dc.contributor.authorRietschel, Men_US
dc.contributor.authorSodhi, Men_US
dc.contributor.authorAlbus, Men_US
dc.contributor.authorBall, Den_US
dc.contributor.authorMaier, Wen_US
dc.contributor.authorDavies, Nen_US
dc.contributor.authorFranzek, Een_US
dc.contributor.authorAbusaad, Ien_US
dc.contributor.authorWeigelt, Ben_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorShimronAbarbanell, Den_US
dc.contributor.authorKerwin, Ren_US
dc.contributor.authorPropping, Pen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorNöthen, MMen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:01:10Z-
dc.date.available2012-11-26T09:01:10Z-
dc.date.issued1997en_US
dc.identifier.citationNeuroscience Letters, 1997, v. 224 n. 2, p. 95-98en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/175768-
dc.description.abstractThe aim of this study was to investigate the possible involvement of genetic variation in serotonin receptors in the aetiology of bipolar affective disorder. The 5-HT(2A) receptor gene was systematically screened for genetic variants by single strand conformation polymorphism (SSCP) methods in subjects with bipolar affective disorder. Four polymorphisms (two structural changes, Thr25Asn and His452Tyr, and two silent polymorphisms, 102-T/C and 516-C/T) which had previously been found in patients with schizophrenia and control subjects were detected. No novel polymorphisms were found in patients with bipolar affective disorder. These polymorphisms were genotyped in a sample of 129 patients and 252 controls of German origin and 176 patients and 182 controls of British origin. No strong associations were found between any of these polymorphisms and bipolar affective disorder. Genetic variation at the 5-HT(2A) receptor gene does not play a major role in the pathogenesis of the disorder.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject5-HT(2A) receptor gene-
dc.subjectbipolar affective disorder-
dc.subjectsingle strand conformation polymorphism-
dc.subject.meshAllelesen_US
dc.subject.meshBipolar Disorder - Geneticsen_US
dc.subject.meshBrain Chemistry - Geneticsen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGermanyen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHumansen_US
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_US
dc.subject.meshReceptors, Serotonin - Geneticsen_US
dc.title5-HT(2A) receptor and bipolar affective disorder: Association studies in affected patientsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3940(97)13456-5en_US
dc.identifier.pmid9086465-
dc.identifier.scopuseid_2-s2.0-0030610477en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030610477&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume224en_US
dc.identifier.issue2en_US
dc.identifier.spage95en_US
dc.identifier.epage98en_US
dc.identifier.isiWOS:A1997WP22600006-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridErdmann, J=7005434855en_US
dc.identifier.scopusauthoridKirov, G=26643478800en_US
dc.identifier.scopusauthoridRietschel, M=7006620620en_US
dc.identifier.scopusauthoridSodhi, M=7004463507en_US
dc.identifier.scopusauthoridAlbus, M=7005502415en_US
dc.identifier.scopusauthoridBall, D=7202703810en_US
dc.identifier.scopusauthoridMaier, W=36046783700en_US
dc.identifier.scopusauthoridDavies, N=7202610654en_US
dc.identifier.scopusauthoridFranzek, E=7005409806en_US
dc.identifier.scopusauthoridAbusaad, I=6506207590en_US
dc.identifier.scopusauthoridWeigelt, B=6603829770en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridShimronAbarbanell, D=6602614474en_US
dc.identifier.scopusauthoridKerwin, R=7102904567en_US
dc.identifier.scopusauthoridPropping, P=35355673000en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridNöthen, MM=35355123900en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.issnl0304-3940-

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