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- Publisher Website: 10.1192/bjp.173.6.527
- Scopus: eid_2-s2.0-0031764632
- PMID: 9926084
- WOS: WOS:000077605400015
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Article: Family history as a predictor of poor long-term outcome in depression
Title | Family history as a predictor of poor long-term outcome in depression |
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Authors | |
Issue Date | 1998 |
Publisher | Royal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/ |
Citation | British Journal Of Psychiatry, 1998, v. 173 DEC., p. 527-530 How to Cite? |
Abstract | Background We investigated whether family history had prognostic significance in depression in a study which addressed some of the methodological short-comings of previous studies. Method We collected family history data on a consecutive series of 89 patients admitted with RDC major depression, blind to the outcome of the proband. This comprised 116, 283 and 120 first-degree relatives examined with the SADS-L, FH-RDC and case note data, respectively. The outcome of 74 of these probands (83%), previously categorised into four operationally defined groups, was then examined. Results A positive family history of severe psychiatric illness (i.e. a relative with a history of either a psychosis, hospitalised depression or suicide) was associated with poor outcome in the proband. This association persisted after controlling for variable family size, age structure and gender. As family history was correlated with neither Kendell's neurotic/psychotic index nor the proband's neuroticism score, an individual with high scores an all three would have a greatly increased chance of having a poor outcome. Conclusions A family history of severe psychiatric illness in a first-degree relative may be useful as one of the vulnerability factors for predicting poor long-term outcome in depression. |
Persistent Identifier | http://hdl.handle.net/10722/175781 |
ISSN | 2023 Impact Factor: 8.7 2023 SCImago Journal Rankings: 2.717 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Duggan, C | en_US |
dc.contributor.author | Sham, P | en_US |
dc.contributor.author | Minne, C | en_US |
dc.contributor.author | Lee, A | en_US |
dc.contributor.author | Murray, R | en_US |
dc.date.accessioned | 2012-11-26T09:01:15Z | - |
dc.date.available | 2012-11-26T09:01:15Z | - |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | British Journal Of Psychiatry, 1998, v. 173 DEC., p. 527-530 | en_US |
dc.identifier.issn | 0007-1250 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175781 | - |
dc.description.abstract | Background We investigated whether family history had prognostic significance in depression in a study which addressed some of the methodological short-comings of previous studies. Method We collected family history data on a consecutive series of 89 patients admitted with RDC major depression, blind to the outcome of the proband. This comprised 116, 283 and 120 first-degree relatives examined with the SADS-L, FH-RDC and case note data, respectively. The outcome of 74 of these probands (83%), previously categorised into four operationally defined groups, was then examined. Results A positive family history of severe psychiatric illness (i.e. a relative with a history of either a psychosis, hospitalised depression or suicide) was associated with poor outcome in the proband. This association persisted after controlling for variable family size, age structure and gender. As family history was correlated with neither Kendell's neurotic/psychotic index nor the proband's neuroticism score, an individual with high scores an all three would have a greatly increased chance of having a poor outcome. Conclusions A family history of severe psychiatric illness in a first-degree relative may be useful as one of the vulnerability factors for predicting poor long-term outcome in depression. | en_US |
dc.language | eng | en_US |
dc.publisher | Royal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/ | en_US |
dc.relation.ispartof | British Journal of Psychiatry | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Depressive Disorder - Genetics | en_US |
dc.subject.mesh | Family Characteristics | en_US |
dc.subject.mesh | Family Health | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hospitalization - Statistics & Numerical Data | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Logistic Models | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Pedigree | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.title | Family history as a predictor of poor long-term outcome in depression | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, P=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1192/bjp.173.6.527 | - |
dc.identifier.pmid | 9926084 | - |
dc.identifier.scopus | eid_2-s2.0-0031764632 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031764632&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 173 | en_US |
dc.identifier.issue | DEC. | en_US |
dc.identifier.spage | 527 | en_US |
dc.identifier.epage | 530 | en_US |
dc.identifier.isi | WOS:000077605400015 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Duggan, C=7101812173 | en_US |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_US |
dc.identifier.scopusauthorid | Minne, C=55393727700 | en_US |
dc.identifier.scopusauthorid | Lee, A=19135120800 | en_US |
dc.identifier.scopusauthorid | Murray, R=35406239400 | en_US |
dc.identifier.issnl | 0007-1250 | - |