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Article: Apical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors

TitleApical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectors
Authors
Seppen, JBarry, SCKlinkspoor, JHKaten, LJLee, SPGarcia, JVOsborne, WRA
Issue Date2000
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2000, v. 74 n. 16, p. 7642-7645 How to Cite?
DOI: http://dx.doi.org/10.1128/JVI.74.16.7642-7645.2000
AbstractIntestinal epithelial cells secrete a protective luminal mucus barrier inhibiting viral gene transfer. Quiescent, polarized monolayers of primary epithelial cells from dog gallbladder and human colon are efficiently transduced through the apical mucus side by lentivirus vectors, suggesting their application to intestinal gene therapy.
Persistent Identifierhttp://hdl.handle.net/10722/175813
ISSN
0022-538X
2021 Impact Factor: 6.549
2020 SCImago Journal Rankings: 2.617
ISI Accession Number ID
WOS:000088342400047
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorSeppen, Jen_US
dc.contributor.authorBarry, SCen_US
dc.contributor.authorKlinkspoor, JHen_US
dc.contributor.authorKaten, LJen_US
dc.contributor.authorLee, SPen_US
dc.contributor.authorGarcia, JVen_US
dc.contributor.authorOsborne, WRAen_US
dc.date.accessioned2012-11-26T09:01:31Z-
dc.date.available2012-11-26T09:01:31Z-
dc.date.issued2000en_US
dc.identifier.citationJournal Of Virology, 2000, v. 74 n. 16, p. 7642-7645en_US
dc.identifier.issn0022-538Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/175813-
dc.description.abstractIntestinal epithelial cells secrete a protective luminal mucus barrier inhibiting viral gene transfer. Quiescent, polarized monolayers of primary epithelial cells from dog gallbladder and human colon are efficiently transduced through the apical mucus side by lentivirus vectors, suggesting their application to intestinal gene therapy.en_US
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_US
dc.relation.ispartofJournal of Virologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCaco-2 Cellsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Polarityen_US
dc.subject.meshDogsen_US
dc.subject.meshEpithelial Cells - Virologyen_US
dc.subject.meshGallbladder - Cytologyen_US
dc.subject.meshGene Transfer Techniquesen_US
dc.subject.meshGenetic Vectors - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestinal Mucosa - Virologyen_US
dc.subject.meshLentivirus - Geneticsen_US
dc.subject.meshMembrane Glycoproteinsen_US
dc.subject.meshMiceen_US
dc.subject.meshMoloney Murine Leukemia Virus - Geneticsen_US
dc.subject.meshTransduction, Geneticen_US
dc.subject.meshViral Envelope Proteins - Geneticsen_US
dc.titleApical gene transfer into quiescent human and canine polarized intestinal epithelial cells by lentivirus vectorsen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1128/JVI.74.16.7642-7645.2000en_US
dc.identifier.pmid10906219-
dc.identifier.scopuseid_2-s2.0-0033865631en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033865631&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume74en_US
dc.identifier.issue16en_US
dc.identifier.spage7642en_US
dc.identifier.epage7645en_US
dc.identifier.isiWOS:000088342400047-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSeppen, J=6701548547en_US
dc.identifier.scopusauthoridBarry, SC=7102878821en_US
dc.identifier.scopusauthoridKlinkspoor, JH=6602590656en_US
dc.identifier.scopusauthoridKaten, LJ=6508370872en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridGarcia, JV=7406129458en_US
dc.identifier.scopusauthoridOsborne, WRA=7005020110en_US
dc.identifier.issnl0022-538X-

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