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- Publisher Website: 10.1016/j.eurpsy.2004.07.007
- Scopus: eid_2-s2.0-12144280612
- PMID: 15642440
- WOS: WOS:000226712800004
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Article: Obstetric complications in patients with schizophrenia and their unaffected siblings
Title | Obstetric complications in patients with schizophrenia and their unaffected siblings |
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Authors | |
Keywords | Family study Obstetric complications Schizophrenia Siblings |
Issue Date | 2005 |
Publisher | Elsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/eurpsy |
Citation | European Psychiatry, 2005, v. 20 n. 1, p. 28-34 How to Cite? |
Abstract | Objective.- We sought to explore whether obstetric complications (OCs) are more likely to occur in the presence of familial/genetic susceptibility for schizophrenia or whether they themselves represent an independent environmental risk factor for schizophrenia. Methods.- The presence of OCs was assessed through maternal interview on 216 subjects, comprising 36 patients with schizophrenia from multiply affected families, 38 of their unaffected siblings, 31 schizophrenic patients with no family history of psychosis, 51 of their unaffected siblings and 60 normal comparison subjects. We examined the familiality of OCs and whether OCs were commoner in the patient and sibling groups than in the control group. Results.- OCs tended to cluster within families, especially in multiply affected families. Patients with schizophrenia, especially those from multiply affected families, had a significantly higher rate of OCs compared to normal comparison subjects, but there was no evidence for an elevated rate of OCs in unaffected siblings. Conclusion.- Our data provides little evidence for a link between OCs and genetic susceptibility to schizophrenia. If high rates of OCs are related to schizophrenia genes, this relationship is weak and will only be detected by very large sample sizes. © 2004 Elsevier SAS. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/175901 |
ISSN | 2023 Impact Factor: 7.2 2023 SCImago Journal Rankings: 1.901 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Walshe, M | en_US |
dc.contributor.author | Mcdonald, C | en_US |
dc.contributor.author | Taylor, M | en_US |
dc.contributor.author | Zhao, J | en_US |
dc.contributor.author | Sham, P | en_US |
dc.contributor.author | Grech, A | en_US |
dc.contributor.author | Schulze, K | en_US |
dc.contributor.author | Bramon, E | en_US |
dc.contributor.author | Murray, RM | en_US |
dc.date.accessioned | 2012-11-26T09:02:20Z | - |
dc.date.available | 2012-11-26T09:02:20Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | European Psychiatry, 2005, v. 20 n. 1, p. 28-34 | en_US |
dc.identifier.issn | 0924-9338 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175901 | - |
dc.description.abstract | Objective.- We sought to explore whether obstetric complications (OCs) are more likely to occur in the presence of familial/genetic susceptibility for schizophrenia or whether they themselves represent an independent environmental risk factor for schizophrenia. Methods.- The presence of OCs was assessed through maternal interview on 216 subjects, comprising 36 patients with schizophrenia from multiply affected families, 38 of their unaffected siblings, 31 schizophrenic patients with no family history of psychosis, 51 of their unaffected siblings and 60 normal comparison subjects. We examined the familiality of OCs and whether OCs were commoner in the patient and sibling groups than in the control group. Results.- OCs tended to cluster within families, especially in multiply affected families. Patients with schizophrenia, especially those from multiply affected families, had a significantly higher rate of OCs compared to normal comparison subjects, but there was no evidence for an elevated rate of OCs in unaffected siblings. Conclusion.- Our data provides little evidence for a link between OCs and genetic susceptibility to schizophrenia. If high rates of OCs are related to schizophrenia genes, this relationship is weak and will only be detected by very large sample sizes. © 2004 Elsevier SAS. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/eurpsy | en_US |
dc.relation.ispartof | European Psychiatry | en_US |
dc.subject | Family study | - |
dc.subject | Obstetric complications | - |
dc.subject | Schizophrenia | - |
dc.subject | Siblings | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Analysis Of Variance | en_US |
dc.subject.mesh | Cluster Analysis | en_US |
dc.subject.mesh | Comorbidity | en_US |
dc.subject.mesh | Family - Psychology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genetic Predisposition To Disease - Genetics - Psychology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Interviews As Topic | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mothers - Psychology | en_US |
dc.subject.mesh | Obstetric Labor Complications - Epidemiology - Psychology | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Schizophrenia - Epidemiology - Genetics | en_US |
dc.subject.mesh | Siblings - Psychology | en_US |
dc.title | Obstetric complications in patients with schizophrenia and their unaffected siblings | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, P=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.eurpsy.2004.07.007 | en_US |
dc.identifier.pmid | 15642440 | - |
dc.identifier.scopus | eid_2-s2.0-12144280612 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-12144280612&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 28 | en_US |
dc.identifier.epage | 34 | en_US |
dc.identifier.isi | WOS:000226712800004 | - |
dc.publisher.place | France | en_US |
dc.identifier.scopusauthorid | Walshe, M=8855469300 | en_US |
dc.identifier.scopusauthorid | McDonald, C=8749594800 | en_US |
dc.identifier.scopusauthorid | Taylor, M=35556198800 | en_US |
dc.identifier.scopusauthorid | Zhao, J=7410311266 | en_US |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_US |
dc.identifier.scopusauthorid | Grech, A=6602744459 | en_US |
dc.identifier.scopusauthorid | Schulze, K=7103137549 | en_US |
dc.identifier.scopusauthorid | Bramon, E=8089378900 | en_US |
dc.identifier.scopusauthorid | Murray, RM=35406239400 | en_US |
dc.identifier.issnl | 0924-9338 | - |