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- Publisher Website: 10.1016/j.neuroimage.2005.05.022
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- PMID: 16009570
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Article: Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study
Title | Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study |
---|---|
Authors | |
Keywords | Endophenotype Genetic Meta-analysis P300 Psychosis Schizophrenia |
Issue Date | 2005 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg |
Citation | Neuroimage, 2005, v. 27 n. 4, p. 960-968 How to Cite? |
Abstract | We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study. Method: Meta-analysis: We conducted a systematic search for articles published between 1983 and 2003 that reported P300 measures in non-psychotic relatives of schizophrenic patients and in healthy controls. Meta-regression analyses were performed using a random effects procedure. The pooled standardized effect size (PSES) was calculated as the difference between the means of the two groups divided by the common standard deviation. Local study: We examined the P300 wave with a standard two-tone oddball paradigm in 30 patients with schizophrenia, 40 non-psychotic relatives, and 40 controls using linear mixed models. Results: Meta-analysis: We pooled 472 relatives and 513 controls. The P300 amplitude was significantly reduced in relatives (PSES = 0.61; 95% CI: 0.30 to 0.91; P < 0.001). The P300 latency was significantly delayed in relatives (PSES of -0.50; 95% CI: -0.88 to -0.13; P = 0.009]. Local study: The patients showed a trend for amplitude reductions (P = 0.06) and significant latency delays (P < 0.01). The relatives displayed normal amplitude but had significant latency delays (P = 0.01). The P300 amplitude and especially the P300 latency are promising alternative phenotypes for genetic research into schizophrenia. © 2005 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/175940 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 2.436 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bramon, E | en_US |
dc.contributor.author | Mcdonald, C | en_US |
dc.contributor.author | Croft, RJ | en_US |
dc.contributor.author | Landau, S | en_US |
dc.contributor.author | Filbey, F | en_US |
dc.contributor.author | Gruzelier, JH | en_US |
dc.contributor.author | Sham, PC | en_US |
dc.contributor.author | Frangou, S | en_US |
dc.contributor.author | Murray, RM | en_US |
dc.date.accessioned | 2012-11-26T09:02:41Z | - |
dc.date.available | 2012-11-26T09:02:41Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Neuroimage, 2005, v. 27 n. 4, p. 960-968 | en_US |
dc.identifier.issn | 1053-8119 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175940 | - |
dc.description.abstract | We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study. Method: Meta-analysis: We conducted a systematic search for articles published between 1983 and 2003 that reported P300 measures in non-psychotic relatives of schizophrenic patients and in healthy controls. Meta-regression analyses were performed using a random effects procedure. The pooled standardized effect size (PSES) was calculated as the difference between the means of the two groups divided by the common standard deviation. Local study: We examined the P300 wave with a standard two-tone oddball paradigm in 30 patients with schizophrenia, 40 non-psychotic relatives, and 40 controls using linear mixed models. Results: Meta-analysis: We pooled 472 relatives and 513 controls. The P300 amplitude was significantly reduced in relatives (PSES = 0.61; 95% CI: 0.30 to 0.91; P < 0.001). The P300 latency was significantly delayed in relatives (PSES of -0.50; 95% CI: -0.88 to -0.13; P = 0.009]. Local study: The patients showed a trend for amplitude reductions (P = 0.06) and significant latency delays (P < 0.01). The relatives displayed normal amplitude but had significant latency delays (P = 0.01). The P300 amplitude and especially the P300 latency are promising alternative phenotypes for genetic research into schizophrenia. © 2005 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg | en_US |
dc.relation.ispartof | NeuroImage | en_US |
dc.subject | Endophenotype | - |
dc.subject | Genetic | - |
dc.subject | Meta-analysis | - |
dc.subject | P300 | - |
dc.subject | Psychosis | - |
dc.subject | Schizophrenia | - |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Event-Related Potentials, P300 - Physiology | en_US |
dc.subject.mesh | Family | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Linear Models | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Psychiatric Status Rating Scales | en_US |
dc.subject.mesh | Schizophrenia - Genetics - Physiopathology | en_US |
dc.title | Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, PC=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.neuroimage.2005.05.022 | en_US |
dc.identifier.pmid | 16009570 | - |
dc.identifier.scopus | eid_2-s2.0-24944542218 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-24944542218&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 960 | en_US |
dc.identifier.epage | 968 | en_US |
dc.identifier.isi | WOS:000232141200024 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Bramon, E=8089378900 | en_US |
dc.identifier.scopusauthorid | McDonald, C=8749594800 | en_US |
dc.identifier.scopusauthorid | Croft, RJ=7004945198 | en_US |
dc.identifier.scopusauthorid | Landau, S=7101776972 | en_US |
dc.identifier.scopusauthorid | Filbey, F=13606061900 | en_US |
dc.identifier.scopusauthorid | Gruzelier, JH=7004536505 | en_US |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_US |
dc.identifier.scopusauthorid | Frangou, S=7004549374 | en_US |
dc.identifier.scopusauthorid | Murray, RM=35406239400 | en_US |
dc.identifier.citeulike | 2302104 | - |
dc.identifier.issnl | 1053-8119 | - |