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Article: A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings
Title | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings |
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Authors | |
Keywords | Endophenotypes Neuropsychology Psychosis Social Cognition |
Issue Date | 2011 |
Publisher | Science China Press. The Journal's web site is located at http://www.springerlink.com/content/1001-6538/ |
Citation | Chinese Science Bulletin, 2011, v. 56 n. 32, p. 3394-3397 How to Cite? |
Abstract | The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. © 2011 Science China Press and Springer-Verlag Berlin Heidelberg. |
Persistent Identifier | http://hdl.handle.net/10722/175988 |
ISSN | 2016 Impact Factor: 1.649 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Lui, SSY | en_US |
dc.contributor.author | Sham, P | en_US |
dc.contributor.author | Chan, RCK | en_US |
dc.contributor.author | Cheung, EFC | en_US |
dc.date.accessioned | 2012-11-26T09:03:19Z | - |
dc.date.available | 2012-11-26T09:03:19Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Chinese Science Bulletin, 2011, v. 56 n. 32, p. 3394-3397 | en_US |
dc.identifier.issn | 1001-6538 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175988 | - |
dc.description.abstract | The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. © 2011 Science China Press and Springer-Verlag Berlin Heidelberg. | en_US |
dc.language | eng | en_US |
dc.publisher | Science China Press. The Journal's web site is located at http://www.springerlink.com/content/1001-6538/ | en_US |
dc.relation.ispartof | Chinese Science Bulletin | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Endophenotypes | en_US |
dc.subject | Neuropsychology | en_US |
dc.subject | Psychosis | en_US |
dc.subject | Social Cognition | en_US |
dc.title | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, P=rp00459 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1007/s11434-011-4734-2 | en_US |
dc.identifier.scopus | eid_2-s2.0-80355133289 | en_US |
dc.identifier.hkuros | 319216 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80355133289&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 56 | en_US |
dc.identifier.issue | 32 | en_US |
dc.identifier.spage | 3394 | en_US |
dc.identifier.epage | 3397 | en_US |
dc.identifier.isi | WOS:000296641800007 | - |
dc.publisher.place | China | en_US |
dc.identifier.scopusauthorid | Lui, SSY=35292835200 | en_US |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_US |
dc.identifier.scopusauthorid | Chan, RCK=35725165500 | en_US |
dc.identifier.scopusauthorid | Cheung, EFC=7006522469 | en_US |
dc.identifier.citeulike | 9761231 | - |
dc.identifier.issnl | 1001-6538 | - |