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- PMID: 10367404
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Article: Oxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cells
Title | Oxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cells |
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Authors | |
Keywords | Binding, competitive Lipoproteins, LDL Macrophages Malondialdelhyde modification Oxidative modification Receptors, LDL |
Issue Date | 1998 |
Publisher | Step Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journal |
Citation | British Journal Of Biomedical Science, 1998, v. 55 n. 3, p. 192-198 How to Cite? |
Abstract | Comparative study of oxidatively modified low-density lipoprotein (Ox-LDL) and malondialdehyde-modified low-density lipoprotein (MDA-LDL) is important for further understanding the biological properties of Ox-LDL, such as its toxic effects, immunogenicity and multiplicity of scavenger receptor binding. In this study, the characteristics of Ox-LDL and MDA-LDL binding and degradation were compared. The results show that when their degree of modification (as determined by relative electrophoretic mobility) was similar, the binding and degradation of Ox-LDL by the macrophage cell line P388D1 were greater than those of MDA-LDL. The binding and degradation of Ox-LDL by macrophages and human umbilical vein endothelial cells increased with the degree of modification. In addition, Ox-LDL or MDA-LDL could competitively inhibit binding of labelled Ox-LDL or labelled MDA-LDL to their respective macrophage receptors, and could partially inhibit each other. |
Persistent Identifier | http://hdl.handle.net/10722/178620 |
ISSN | 2021 Impact Factor: 2.432 2020 SCImago Journal Rankings: 0.448 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhou, M | en_US |
dc.contributor.author | Chen, Y | en_US |
dc.contributor.author | Liu, S | en_US |
dc.contributor.author | Ding, Z | en_US |
dc.contributor.author | Pang, Z | en_US |
dc.contributor.author | Wan, J | en_US |
dc.date.accessioned | 2012-12-19T09:48:45Z | - |
dc.date.available | 2012-12-19T09:48:45Z | - |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | British Journal Of Biomedical Science, 1998, v. 55 n. 3, p. 192-198 | en_US |
dc.identifier.issn | 0967-4845 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178620 | - |
dc.description.abstract | Comparative study of oxidatively modified low-density lipoprotein (Ox-LDL) and malondialdehyde-modified low-density lipoprotein (MDA-LDL) is important for further understanding the biological properties of Ox-LDL, such as its toxic effects, immunogenicity and multiplicity of scavenger receptor binding. In this study, the characteristics of Ox-LDL and MDA-LDL binding and degradation were compared. The results show that when their degree of modification (as determined by relative electrophoretic mobility) was similar, the binding and degradation of Ox-LDL by the macrophage cell line P388D1 were greater than those of MDA-LDL. The binding and degradation of Ox-LDL by macrophages and human umbilical vein endothelial cells increased with the degree of modification. In addition, Ox-LDL or MDA-LDL could competitively inhibit binding of labelled Ox-LDL or labelled MDA-LDL to their respective macrophage receptors, and could partially inhibit each other. | en_US |
dc.language | eng | en_US |
dc.publisher | Step Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journal | en_US |
dc.relation.ispartof | British Journal of Biomedical Science | en_US |
dc.subject | Binding, competitive | - |
dc.subject | Lipoproteins, LDL | - |
dc.subject | Macrophages | - |
dc.subject | Malondialdelhyde modification | - |
dc.subject | Oxidative modification | - |
dc.subject | Receptors, LDL | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cell Culture Techniques | en_US |
dc.subject.mesh | Endothelium, Vascular - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lipoproteins, Ldl - Metabolism | en_US |
dc.subject.mesh | Macrophages, Peritoneal - Metabolism | en_US |
dc.subject.mesh | Malondialdehyde - Metabolism | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Oxidation-Reduction | en_US |
dc.title | Oxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cells | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wan, J: jmfwan@hku.hk | en_US |
dc.identifier.authority | Wan, J=rp00798 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 10367404 | - |
dc.identifier.scopus | eid_2-s2.0-0031756156 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031756156&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 192 | en_US |
dc.identifier.epage | 198 | en_US |
dc.identifier.isi | WOS:000076519700006 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Zhou, M=7403506134 | en_US |
dc.identifier.scopusauthorid | Chen, Y=16745998900 | en_US |
dc.identifier.scopusauthorid | Liu, S=7409463469 | en_US |
dc.identifier.scopusauthorid | Ding, Z=35247593000 | en_US |
dc.identifier.scopusauthorid | Pang, Z=7103343225 | en_US |
dc.identifier.scopusauthorid | Wan, J=8930305000 | en_US |
dc.identifier.issnl | 0967-4845 | - |