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- Publisher Website: 10.1007/s10038-003-0068-5
- Scopus: eid_2-s2.0-0344873312
- PMID: 14505233
- WOS: WOS:000186242800004
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Article: Interaction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese
Title | Interaction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese |
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Authors | |
Keywords | Age Bone mineral density (BMD) ER-α gene Interaction Sex VDR gene |
Issue Date | 2003 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html |
Citation | Journal Of Human Genetics, 2003, v. 48 n. 10, p. 514-519 How to Cite? |
Abstract | We evaluated the interaction effects between the estrogen receptor α gene (ER-α), vitamin D receptor gene (VDR), age and sex on bone mineral density (BMD) in a sample of 340 unrelated males and 297 unrelated females from 401 Chinese nuclear families. Polymorphisms of PvuII and XbaI in the ER-α gene and ApaI in the VDR gene were detected by RFLP, and ER-α genotype was defined by the haplotype reconstructed according to the two loci. In the females, significant ER-VDR gene interaction (P<0.05) was found on the lumbar spine BMD. Such interaction might account for approximately 1.0% of the BMD variation. At the femoral neck and trochanter, significant ER-age interaction effects were observed, which might explain 0.3% BMD variation for both skeletal sites. In the males, significant VDR-age interaction was found on femoral neck BMD (P < 0.05), and it accounted for 0.6% BMD variation. These interaction effects were largely dependent on gender groups, suggesting there may exist ER-VDR-sex, ER-age-sex, and VDR-age-sex complex interactions in our Chinese sample. |
Persistent Identifier | http://hdl.handle.net/10722/178832 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 1.148 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Long, J | en_US |
dc.contributor.author | Liu, P | en_US |
dc.contributor.author | Zhang, Y | en_US |
dc.contributor.author | Shen, H | en_US |
dc.contributor.author | Liu, Y | en_US |
dc.contributor.author | Dvornyk, V | en_US |
dc.contributor.author | Deng, HW | en_US |
dc.date.accessioned | 2012-12-19T09:50:01Z | - |
dc.date.available | 2012-12-19T09:50:01Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Journal Of Human Genetics, 2003, v. 48 n. 10, p. 514-519 | en_US |
dc.identifier.issn | 1434-5161 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178832 | - |
dc.description.abstract | We evaluated the interaction effects between the estrogen receptor α gene (ER-α), vitamin D receptor gene (VDR), age and sex on bone mineral density (BMD) in a sample of 340 unrelated males and 297 unrelated females from 401 Chinese nuclear families. Polymorphisms of PvuII and XbaI in the ER-α gene and ApaI in the VDR gene were detected by RFLP, and ER-α genotype was defined by the haplotype reconstructed according to the two loci. In the females, significant ER-VDR gene interaction (P<0.05) was found on the lumbar spine BMD. Such interaction might account for approximately 1.0% of the BMD variation. At the femoral neck and trochanter, significant ER-age interaction effects were observed, which might explain 0.3% BMD variation for both skeletal sites. In the males, significant VDR-age interaction was found on femoral neck BMD (P < 0.05), and it accounted for 0.6% BMD variation. These interaction effects were largely dependent on gender groups, suggesting there may exist ER-VDR-sex, ER-age-sex, and VDR-age-sex complex interactions in our Chinese sample. | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html | en_US |
dc.relation.ispartof | Journal of Human Genetics | en_US |
dc.subject | Age | - |
dc.subject | Bone mineral density (BMD) | - |
dc.subject | ER-α gene | - |
dc.subject | Interaction | - |
dc.subject | Sex | - |
dc.subject | VDR gene | - |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Bone Density - Genetics | en_US |
dc.subject.mesh | China - Epidemiology | en_US |
dc.subject.mesh | Estrogen Receptor Alpha | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Receptors, Calcitriol - Genetics | en_US |
dc.subject.mesh | Receptors, Estrogen - Genetics | en_US |
dc.subject.mesh | Regression Analysis | en_US |
dc.subject.mesh | Sex Factors | en_US |
dc.title | Interaction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese | en_US |
dc.type | Article | en_US |
dc.identifier.email | Dvornyk, V: dvornyk@hku.hk | en_US |
dc.identifier.authority | Dvornyk, V=rp00693 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s10038-003-0068-5 | en_US |
dc.identifier.pmid | 14505233 | - |
dc.identifier.scopus | eid_2-s2.0-0344873312 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0344873312&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.spage | 514 | en_US |
dc.identifier.epage | 519 | en_US |
dc.identifier.isi | WOS:000186242800004 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Long, J=7403446542 | en_US |
dc.identifier.scopusauthorid | Liu, P=7404618030 | en_US |
dc.identifier.scopusauthorid | Zhang, Y=12781205700 | en_US |
dc.identifier.scopusauthorid | Shen, H=36126870600 | en_US |
dc.identifier.scopusauthorid | Liu, Y=36065513000 | en_US |
dc.identifier.scopusauthorid | Dvornyk, V=6701789786 | en_US |
dc.identifier.scopusauthorid | Deng, HW=34568563000 | en_US |
dc.identifier.issnl | 1434-5161 | - |