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- Publisher Website: 10.1016/j.aquatox.2009.04.005
- Scopus: eid_2-s2.0-67349250916
- PMID: 19443055
- WOS: WOS:000268412600006
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Article: Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish
Title | Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish |
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Authors | |
Keywords | Endocrine disruption Fluorotelomer alcohols Gene transcription Hypothalamic-pituitary-gonadal (HPG) axis Sex hormone |
Issue Date | 2009 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/aquatox |
Citation | Aquatic Toxicology, 2009, v. 93 n. 2-3, p. 131-137 How to Cite? |
Abstract | Fluorotelomer alcohols (FTOHs) have shown estrogenic activity in vitro and in vivo, but the mechanism of this activity is not known. In this study, 18-week-old zebrafish (Danio rerio) were exposed to 0, 0.03, 0.3 and 3.0 mg/l 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) for 7 days, and the effects on plasma sex hormone levels were measured followed by use of real-time PCR to examine selected gene expression in hypothalamic-pituitary-gonadal (HPG) axis and liver. Exposure to 6:2 FTOH significantly increased plasma estradiol (E2) and testosterone (T) levels in both males and females. Furthermore, the ratio of T/E2 was reduced in females while increased in males. In females, the increase of E2 was accompanied by up-regulated hepatic estrogenic receptor α (ERα) and vitellogenin (VTG1 and VTG3) expression. In males, the elevation of the T level is consistent with the up-regulation of cytochrome P450 c17α-hydroxylase, 17, 20-lase (CYP17) and the down-regulation of cytochrome P450 aromatase A (CYP19A). The present study demonstrated that waterborne exposure to 6:2 FTOH alter plasma sex hormone levels and the ratio of T/E2, as well as the transcriptional profiles of some genes in the HPG axis and liver. The results suggested that FTOHs may disturb fish reproduction through endocrine disrupted activity. © 2009 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/179138 |
ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 1.099 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, C | en_US |
dc.contributor.author | Yu, L | en_US |
dc.contributor.author | Deng, J | en_US |
dc.contributor.author | Lam, PKS | en_US |
dc.contributor.author | Wu, RSS | en_US |
dc.contributor.author | Zhou, B | en_US |
dc.date.accessioned | 2012-12-19T09:52:17Z | - |
dc.date.available | 2012-12-19T09:52:17Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Aquatic Toxicology, 2009, v. 93 n. 2-3, p. 131-137 | en_US |
dc.identifier.issn | 0166-445X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179138 | - |
dc.description.abstract | Fluorotelomer alcohols (FTOHs) have shown estrogenic activity in vitro and in vivo, but the mechanism of this activity is not known. In this study, 18-week-old zebrafish (Danio rerio) were exposed to 0, 0.03, 0.3 and 3.0 mg/l 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) for 7 days, and the effects on plasma sex hormone levels were measured followed by use of real-time PCR to examine selected gene expression in hypothalamic-pituitary-gonadal (HPG) axis and liver. Exposure to 6:2 FTOH significantly increased plasma estradiol (E2) and testosterone (T) levels in both males and females. Furthermore, the ratio of T/E2 was reduced in females while increased in males. In females, the increase of E2 was accompanied by up-regulated hepatic estrogenic receptor α (ERα) and vitellogenin (VTG1 and VTG3) expression. In males, the elevation of the T level is consistent with the up-regulation of cytochrome P450 c17α-hydroxylase, 17, 20-lase (CYP17) and the down-regulation of cytochrome P450 aromatase A (CYP19A). The present study demonstrated that waterborne exposure to 6:2 FTOH alter plasma sex hormone levels and the ratio of T/E2, as well as the transcriptional profiles of some genes in the HPG axis and liver. The results suggested that FTOHs may disturb fish reproduction through endocrine disrupted activity. © 2009 Elsevier B.V. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/aquatox | en_US |
dc.relation.ispartof | Aquatic Toxicology | en_US |
dc.subject | Endocrine disruption | - |
dc.subject | Fluorotelomer alcohols | - |
dc.subject | Gene transcription | - |
dc.subject | Hypothalamic-pituitary-gonadal (HPG) axis | - |
dc.subject | Sex hormone | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Endocrine Disruptors - Toxicity | en_US |
dc.subject.mesh | Environmental Exposure | en_US |
dc.subject.mesh | Estradiol - Blood | en_US |
dc.subject.mesh | Estrogens - Toxicity | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fluorocarbons - Toxicity | en_US |
dc.subject.mesh | Gene Expression - Drug Effects | en_US |
dc.subject.mesh | Gonadal Steroid Hormones - Blood | en_US |
dc.subject.mesh | Hypothalamo-Hypophyseal System - Metabolism | en_US |
dc.subject.mesh | Liver - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Testosterone - Blood | en_US |
dc.subject.mesh | Transcription, Genetic - Drug Effects | en_US |
dc.subject.mesh | Water Pollutants, Chemical - Toxicity | en_US |
dc.subject.mesh | Zebrafish - Blood - Genetics - Metabolism | en_US |
dc.title | Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wu, RSS: rudolfwu@hku.hk | en_US |
dc.identifier.authority | Wu, RSS=rp01398 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.aquatox.2009.04.005 | en_US |
dc.identifier.pmid | 19443055 | - |
dc.identifier.scopus | eid_2-s2.0-67349250916 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67349250916&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 93 | en_US |
dc.identifier.issue | 2-3 | en_US |
dc.identifier.spage | 131 | en_US |
dc.identifier.epage | 137 | en_US |
dc.identifier.isi | WOS:000268412600006 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Liu, C=8318316300 | en_US |
dc.identifier.scopusauthorid | Yu, L=37022805800 | en_US |
dc.identifier.scopusauthorid | Deng, J=35304700000 | en_US |
dc.identifier.scopusauthorid | Lam, PKS=7202365776 | en_US |
dc.identifier.scopusauthorid | Wu, RSS=7402945079 | en_US |
dc.identifier.scopusauthorid | Zhou, B=7401906781 | en_US |
dc.identifier.citeulike | 4994487 | - |
dc.identifier.issnl | 0166-445X | - |