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- Publisher Website: 10.4269/ajtmh.1988.39.26
- Scopus: eid_2-s2.0-0023790113
- PMID: 3041855
- WOS: WOS:A1988P675500005
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Article: Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malaria
Title | Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malaria |
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Authors | |
Issue Date | 1988 |
Publisher | American Society of Tropical Medicine and Hygiene. The Journal's web site is located at http://www.ajtmh.org/ |
Citation | American Journal Of Tropical Medicine And Hygiene, 1988, v. 39 n. 1, p. 26-32 How to Cite? |
Abstract | Antibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P. vivax in humans which suppress infectivity of the parasites to the vector at high concentrations can, at lower concentrations, have the opposite effect and enhance the level of malaria infection in the mosquitoes. Infectivity enhancing effects of up to 12-fold were demonstrated when a transmission blocking monoclonal antibody and immune human sera were diluted, in some undiluted immune human sera, and in the sera of vivax malaria patients during convalescence after drug cure. |
Persistent Identifier | http://hdl.handle.net/10722/179734 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.834 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Peiris, JSM | en_US |
dc.contributor.author | Premawansa, S | en_US |
dc.contributor.author | Ranawaka, MBR | en_US |
dc.contributor.author | Udagama, PV | en_US |
dc.contributor.author | Munasinghe, YD | en_US |
dc.contributor.author | Nanayakkara, MV | en_US |
dc.contributor.author | Gamage, CP | en_US |
dc.contributor.author | Carter, R | en_US |
dc.contributor.author | David, PH | en_US |
dc.contributor.author | Mendis, KN | en_US |
dc.date.accessioned | 2012-12-19T10:04:09Z | - |
dc.date.available | 2012-12-19T10:04:09Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | American Journal Of Tropical Medicine And Hygiene, 1988, v. 39 n. 1, p. 26-32 | en_US |
dc.identifier.issn | 0002-9637 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179734 | - |
dc.description.abstract | Antibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P. vivax in humans which suppress infectivity of the parasites to the vector at high concentrations can, at lower concentrations, have the opposite effect and enhance the level of malaria infection in the mosquitoes. Infectivity enhancing effects of up to 12-fold were demonstrated when a transmission blocking monoclonal antibody and immune human sera were diluted, in some undiluted immune human sera, and in the sera of vivax malaria patients during convalescence after drug cure. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society of Tropical Medicine and Hygiene. The Journal's web site is located at http://www.ajtmh.org/ | en_US |
dc.relation.ispartof | American Journal of Tropical Medicine and Hygiene | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anopheles - Parasitology | en_US |
dc.subject.mesh | Antibodies, Monoclonal - Immunology | en_US |
dc.subject.mesh | Antibodies, Protozoan - Immunology | en_US |
dc.subject.mesh | Binding, Competitive | en_US |
dc.subject.mesh | Electrophoresis, Polyacrylamide Gel | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fluorescent Antibody Technique | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hybridomas | en_US |
dc.subject.mesh | Immune Sera - Immunology | en_US |
dc.subject.mesh | Immunoassay | en_US |
dc.subject.mesh | Insect Vectors - Parasitology | en_US |
dc.subject.mesh | Malaria - Immunology - Transmission | en_US |
dc.subject.mesh | Plasmodium Vivax - Immunology | en_US |
dc.title | Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malaria | en_US |
dc.type | Article | en_US |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_US |
dc.identifier.authority | Peiris, JSM=rp00410 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.4269/ajtmh.1988.39.26 | - |
dc.identifier.pmid | 3041855 | - |
dc.identifier.scopus | eid_2-s2.0-0023790113 | en_US |
dc.identifier.volume | 39 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 26 | en_US |
dc.identifier.epage | 32 | en_US |
dc.identifier.isi | WOS:A1988P675500005 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Peiris, JSM=7005486823 | en_US |
dc.identifier.scopusauthorid | Premawansa, S=6601964639 | en_US |
dc.identifier.scopusauthorid | Ranawaka, MBR=7801554097 | en_US |
dc.identifier.scopusauthorid | Udagama, PV=6505767945 | en_US |
dc.identifier.scopusauthorid | Munasinghe, YD=6504111896 | en_US |
dc.identifier.scopusauthorid | Nanayakkara, MV=6506356377 | en_US |
dc.identifier.scopusauthorid | Gamage, CP=6602278025 | en_US |
dc.identifier.scopusauthorid | Carter, R=7402936927 | en_US |
dc.identifier.scopusauthorid | David, PH=7201509648 | en_US |
dc.identifier.scopusauthorid | Mendis, KN=7004958149 | en_US |
dc.identifier.issnl | 0002-9637 | - |