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- Publisher Website: 10.1016/0035-9203(90)90372-L
- Scopus: eid_2-s2.0-0025176818
- PMID: 2111943
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Article: Antibodies to Plasmodium falciparum sporozoites following a malarial outbreak in a non-endemic area of Sri Lanka
Title | Antibodies to Plasmodium falciparum sporozoites following a malarial outbreak in a non-endemic area of Sri Lanka |
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Authors | |
Issue Date | 1990 |
Publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/trstmh |
Citation | Transactions Of The Royal Society Of Tropical Medicine And Hygiene, 1990, v. 84 n. 1, p. 35-39 How to Cite? |
Abstract | An enzyme-linked immunosorbent assay (ELISA) based on the synthetic peptide (NANP) 40 was used to characterize the sporozoite antibodies in an unusual Plasmodium falciparum outbreak in a non-malarious ara in Sri Lanka. A positive antibody response was seen in 62% of patients with their first P. falciparum illness. There was no correlation between sporozoite antibodies and the antibody against blood stages, determined by immunofluorescence assay. The majority (91%) of the patients lost the antibodies to circumsporozoite (CS) protein within one year (in the absence of re-exposure). Three patients had high levels of CS antibodies even after one year, and this persistence was related to the level of the initial antibody response. In the area of the outbreak 10% of schoolchildren had antibodies to the (NANP) 40 peptide. 21% of the 42 children with present or past overt malaria were antibody positive. Of the children with no such background, 8% were antibody positive. The corresponding seropositivity rates for asexual blood stages were 31% and 1% for the 2 groups respectively. It is concluded that (NANP) 40 ELISA is potentially a valuable tool in sero-epidemiology, particularly in situations of seasonal transmission and recurrences due to drug resistance. |
Persistent Identifier | http://hdl.handle.net/10722/179737 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.612 |
DC Field | Value | Language |
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dc.contributor.author | De Wijesundera, SM | en_US |
dc.contributor.author | Peiris, JSM | en_US |
dc.contributor.author | Ariyaratne, YG | en_US |
dc.contributor.author | Verdini, AS | en_US |
dc.contributor.author | Pessi, A | en_US |
dc.contributor.author | Del Giudice, G | en_US |
dc.date.accessioned | 2012-12-19T10:04:11Z | - |
dc.date.available | 2012-12-19T10:04:11Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Transactions Of The Royal Society Of Tropical Medicine And Hygiene, 1990, v. 84 n. 1, p. 35-39 | en_US |
dc.identifier.issn | 0035-9203 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179737 | - |
dc.description.abstract | An enzyme-linked immunosorbent assay (ELISA) based on the synthetic peptide (NANP) 40 was used to characterize the sporozoite antibodies in an unusual Plasmodium falciparum outbreak in a non-malarious ara in Sri Lanka. A positive antibody response was seen in 62% of patients with their first P. falciparum illness. There was no correlation between sporozoite antibodies and the antibody against blood stages, determined by immunofluorescence assay. The majority (91%) of the patients lost the antibodies to circumsporozoite (CS) protein within one year (in the absence of re-exposure). Three patients had high levels of CS antibodies even after one year, and this persistence was related to the level of the initial antibody response. In the area of the outbreak 10% of schoolchildren had antibodies to the (NANP) 40 peptide. 21% of the 42 children with present or past overt malaria were antibody positive. Of the children with no such background, 8% were antibody positive. The corresponding seropositivity rates for asexual blood stages were 31% and 1% for the 2 groups respectively. It is concluded that (NANP) 40 ELISA is potentially a valuable tool in sero-epidemiology, particularly in situations of seasonal transmission and recurrences due to drug resistance. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/trstmh | en_US |
dc.relation.ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antibodies, Protozoan - Analysis - Immunology | en_US |
dc.subject.mesh | Antibody Formation | en_US |
dc.subject.mesh | Apicomplexa - Immunology | en_US |
dc.subject.mesh | Disease Outbreaks | en_US |
dc.subject.mesh | Enzyme-Linked Immunosorbent Assay | en_US |
dc.subject.mesh | Fluorescent Antibody Technique | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Malaria - Epidemiology - Immunology | en_US |
dc.subject.mesh | Plasmodium Falciparum - Immunology | en_US |
dc.subject.mesh | Sri Lanka | en_US |
dc.title | Antibodies to Plasmodium falciparum sporozoites following a malarial outbreak in a non-endemic area of Sri Lanka | en_US |
dc.type | Article | en_US |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_US |
dc.identifier.authority | Peiris, JSM=rp00410 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0035-9203(90)90372-L | en_US |
dc.identifier.pmid | 2111943 | - |
dc.identifier.scopus | eid_2-s2.0-0025176818 | en_US |
dc.identifier.volume | 84 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 35 | en_US |
dc.identifier.epage | 39 | en_US |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | De Wijesundera, SM=6508111405 | en_US |
dc.identifier.scopusauthorid | Peiris, JSM=7005486823 | en_US |
dc.identifier.scopusauthorid | Ariyaratne, YG=11238780000 | en_US |
dc.identifier.scopusauthorid | Verdini, AS=7004002171 | en_US |
dc.identifier.scopusauthorid | Pessi, A=7005806554 | en_US |
dc.identifier.scopusauthorid | Del Giudice, G=7006629475 | en_US |
dc.identifier.issnl | 0035-9203 | - |