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Article: Cross-protectiveness and immunogenicity of influenza A/Duck/Singapore/3/ 97(H5) vaccines against infection with A/Vietnam/1203/04(H5N1) virus in ferrets

TitleCross-protectiveness and immunogenicity of influenza A/Duck/Singapore/3/ 97(H5) vaccines against infection with A/Vietnam/1203/04(H5N1) virus in ferrets
Authors
Lipatov, ASHoffmann, ESalomon, RYen, HLWebster, RG
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2006, v. 194 n. 8, p. 1040-1043 How to Cite?
DOI: http://dx.doi.org/10.1086/507709
AbstractFerrets were immunized with two 7-μg doses of hemagglutinin from inactivated whole-virus vaccines containing the hemagglutinin gene of A/Duck/Singapore/3/97(H5N3) then inoculated with a lethal dose of A/Vietnam/1203/04(H5N1) (Viet/1203/04). Serum samples did not react with Viet/1203/04 in hemagglutination-inhibition (HI) or virus-neutralization (VN) tests. All vaccinated ferrets survived the challenge, whereas all mock-immunized ferrets died. Immunized ferrets had significantly lower virus titers in the upper respiratory tract and less-severe disease. Vaccine generated from antigenically different H5 virus protects against infection by a highly pathogenic H5 strain. Neither HI nor VN testing provides correlates of cross-protection in ferrets. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179796
ISSN
0022-1899
2021 Impact Factor: 7.759
2020 SCImago Journal Rankings: 2.690
ISI Accession Number ID
WOS:000240548500004
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLipatov, ASen_US
dc.contributor.authorHoffmann, Een_US
dc.contributor.authorSalomon, Ren_US
dc.contributor.authorYen, HLen_US
dc.contributor.authorWebster, RGen_US
dc.date.accessioned2012-12-19T10:04:51Z-
dc.date.available2012-12-19T10:04:51Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Infectious Diseases, 2006, v. 194 n. 8, p. 1040-1043en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/179796-
dc.description.abstractFerrets were immunized with two 7-μg doses of hemagglutinin from inactivated whole-virus vaccines containing the hemagglutinin gene of A/Duck/Singapore/3/97(H5N3) then inoculated with a lethal dose of A/Vietnam/1203/04(H5N1) (Viet/1203/04). Serum samples did not react with Viet/1203/04 in hemagglutination-inhibition (HI) or virus-neutralization (VN) tests. All vaccinated ferrets survived the challenge, whereas all mock-immunized ferrets died. Immunized ferrets had significantly lower virus titers in the upper respiratory tract and less-severe disease. Vaccine generated from antigenically different H5 virus protects against infection by a highly pathogenic H5 strain. Neither HI nor VN testing provides correlates of cross-protection in ferrets. © 2006 by the Infectious Diseases Society of America. All rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Viral - Biosynthesisen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshFerretsen_US
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - Genetics - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Immunologyen_US
dc.subject.meshInfluenza Vaccines - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshInfluenza, Human - Prevention & Controlen_US
dc.subject.meshMutationen_US
dc.titleCross-protectiveness and immunogenicity of influenza A/Duck/Singapore/3/ 97(H5) vaccines against infection with A/Vietnam/1203/04(H5N1) virus in ferretsen_US
dc.typeArticleen_US
dc.identifier.emailYen, HL: hyen@hku.hken_US
dc.identifier.authorityYen, HL=rp00304en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1086/507709en_US
dc.identifier.pmid16991078-
dc.identifier.scopuseid_2-s2.0-33749617718en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749617718&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume194en_US
dc.identifier.issue8en_US
dc.identifier.spage1040en_US
dc.identifier.epage1043en_US
dc.identifier.isiWOS:000240548500004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLipatov, AS=7005117347en_US
dc.identifier.scopusauthoridHoffmann, E=7201369718en_US
dc.identifier.scopusauthoridSalomon, R=12786463900en_US
dc.identifier.scopusauthoridYen, HL=7102476668en_US
dc.identifier.scopusauthoridWebster, RG=36048363100en_US
dc.identifier.issnl0022-1899-

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