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- Publisher Website: 10.1002/(SICI)1097-0223(199704)17:4<327::AID-PD67>3.0.CO;2-N
- Scopus: eid_2-s2.0-0030980003
- PMID: 9160385
- WOS: WOS:A1997WY69900006
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Article: Early ultrasound prediction of pregnancies affected by homozygous α-thalassaemia-1
Title | Early ultrasound prediction of pregnancies affected by homozygous α-thalassaemia-1 |
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Authors | |
Keywords | α-thalassaemia Cardiomegaly Placenta Prenatal diagnosis Prenatal ultrasonography |
Issue Date | 1997 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 |
Citation | Prenatal Diagnosis, 1997, v. 17 n. 4, p. 327-332 How to Cite? |
Abstract | Homozygous α-thalassaemia-1 is conventionally diagnosed by invasive testing on all at-risk pregnancies. We evaluated the diagnostic efficacy of non-invasive abdominal ultrasonographic cardiothoracic ratio measurement in 62 pregnancies at 13-14 weeks and 75 pregnancies at 17-18 weeks. This performed better than placental thickness measurement. Using a cardiothoracic ratio cut-off level of ≤ 0.5, 75 per cent of affected pregnancies were detected at 13-14 weeks and all cases were detected at 17-18 weeks. False-positive rates were 7 and 8 per cent, respectively. There was no false-positive diagnosis if the cardiothoracic ratio was ≤ 0.53. With this approach, invasive procedures can be selectively performed and fewer pregnancies will be lost unnecessarily. The reduction in medical expenses is likely to be substantial. |
Persistent Identifier | http://hdl.handle.net/10722/180625 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.986 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, YH | en_US |
dc.contributor.author | Ghosh, A | en_US |
dc.contributor.author | Tang, MHY | en_US |
dc.contributor.author | Lee, CP | en_US |
dc.contributor.author | Sin, SY | en_US |
dc.date.accessioned | 2013-01-28T01:40:44Z | - |
dc.date.available | 2013-01-28T01:40:44Z | - |
dc.date.issued | 1997 | en_US |
dc.identifier.citation | Prenatal Diagnosis, 1997, v. 17 n. 4, p. 327-332 | en_US |
dc.identifier.issn | 0197-3851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180625 | - |
dc.description.abstract | Homozygous α-thalassaemia-1 is conventionally diagnosed by invasive testing on all at-risk pregnancies. We evaluated the diagnostic efficacy of non-invasive abdominal ultrasonographic cardiothoracic ratio measurement in 62 pregnancies at 13-14 weeks and 75 pregnancies at 17-18 weeks. This performed better than placental thickness measurement. Using a cardiothoracic ratio cut-off level of ≤ 0.5, 75 per cent of affected pregnancies were detected at 13-14 weeks and all cases were detected at 17-18 weeks. False-positive rates were 7 and 8 per cent, respectively. There was no false-positive diagnosis if the cardiothoracic ratio was ≤ 0.53. With this approach, invasive procedures can be selectively performed and fewer pregnancies will be lost unnecessarily. The reduction in medical expenses is likely to be substantial. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_US |
dc.relation.ispartof | Prenatal Diagnosis | en_US |
dc.subject | α-thalassaemia | - |
dc.subject | Cardiomegaly | - |
dc.subject | Placenta | - |
dc.subject | Prenatal diagnosis | - |
dc.subject | Prenatal ultrasonography | - |
dc.subject.mesh | False Positive Reactions | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Diseases - Ultrasonography | en_US |
dc.subject.mesh | Fetal Heart - Ultrasonography | en_US |
dc.subject.mesh | Gestational Age | en_US |
dc.subject.mesh | Homozygote | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Placenta - Ultrasonography | en_US |
dc.subject.mesh | Predictive Value Of Tests | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Roc Curve | en_US |
dc.subject.mesh | Sensitivity And Specificity | en_US |
dc.subject.mesh | Thorax - Embryology - Ultrasonography | en_US |
dc.subject.mesh | Ultrasonography, Prenatal | en_US |
dc.subject.mesh | Alpha-Thalassemia - Genetics - Ultrasonography | en_US |
dc.title | Early ultrasound prediction of pregnancies affected by homozygous α-thalassaemia-1 | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, MHY=rp01701 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/(SICI)1097-0223(199704)17:4<327::AID-PD67>3.0.CO;2-N | en_US |
dc.identifier.pmid | 9160385 | - |
dc.identifier.scopus | eid_2-s2.0-0030980003 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030980003&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 327 | en_US |
dc.identifier.epage | 332 | en_US |
dc.identifier.isi | WOS:A1997WY69900006 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lam, YH=7202563903 | en_US |
dc.identifier.scopusauthorid | Ghosh, A=7403963873 | en_US |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_US |
dc.identifier.scopusauthorid | Lee, CP=7410149538 | en_US |
dc.identifier.scopusauthorid | Sin, SY=7006553270 | en_US |
dc.identifier.issnl | 0197-3851 | - |