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- Publisher Website: 10.1586/14737159.4.3.333
- Scopus: eid_2-s2.0-2542421711
- PMID: 15137900
- WOS: WOS:000221285900007
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Article: Rapid aneuploidy screening (FISH or QF-PCR): The changing scene in prenatal diagnosis?
Title | Rapid aneuploidy screening (FISH or QF-PCR): The changing scene in prenatal diagnosis? |
---|---|
Authors | |
Keywords | Amniocentesis FISH Prenatal diagnosis QF-PCR Rapid aneuploidy screening |
Issue Date | 2004 |
Publisher | Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/erm |
Citation | Expert Review Of Molecular Diagnostics, 2004, v. 4 n. 3, p. 333-337 How to Cite? |
Abstract | The accuracy of new molecular diagnostics, fluoresence in situ hybridization or quantitative fluorescence-PCR (collectively known as rapid aneuploidy screening), in prenatal diagnosis has already been demonstrated in a number of large studies. The challenge now is how to apply them clinically in the most cost-effective manner. It is now time to appraise whether rapid aneuploidy screening can replace traditional karyotyping when amniocenteses are performed for increased risk of Down's syndrome by maternal serum screening or advanced maternal age in the absence of ultrasound abnormality. The ten most recent studies from the literature within this research theme are reviewed and the pros and cons of this new approach in prenatal diagnosis are discussed, including the suggestion of future studies. |
Persistent Identifier | http://hdl.handle.net/10722/180676 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 0.823 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, WC | en_US |
dc.contributor.author | Lau, ET | en_US |
dc.contributor.author | Lao, TT | en_US |
dc.contributor.author | Tang, MHY | en_US |
dc.date.accessioned | 2013-01-28T01:41:02Z | - |
dc.date.available | 2013-01-28T01:41:02Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Expert Review Of Molecular Diagnostics, 2004, v. 4 n. 3, p. 333-337 | en_US |
dc.identifier.issn | 1473-7159 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180676 | - |
dc.description.abstract | The accuracy of new molecular diagnostics, fluoresence in situ hybridization or quantitative fluorescence-PCR (collectively known as rapid aneuploidy screening), in prenatal diagnosis has already been demonstrated in a number of large studies. The challenge now is how to apply them clinically in the most cost-effective manner. It is now time to appraise whether rapid aneuploidy screening can replace traditional karyotyping when amniocenteses are performed for increased risk of Down's syndrome by maternal serum screening or advanced maternal age in the absence of ultrasound abnormality. The ten most recent studies from the literature within this research theme are reviewed and the pros and cons of this new approach in prenatal diagnosis are discussed, including the suggestion of future studies. | en_US |
dc.language | eng | en_US |
dc.publisher | Expert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/erm | en_US |
dc.relation.ispartof | Expert Review of Molecular Diagnostics | en_US |
dc.subject | Amniocentesis | - |
dc.subject | FISH | - |
dc.subject | Prenatal diagnosis | - |
dc.subject | QF-PCR | - |
dc.subject | Rapid aneuploidy screening | - |
dc.subject.mesh | Amniocentesis | en_US |
dc.subject.mesh | Aneuploidy | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | False Negative Reactions | en_US |
dc.subject.mesh | False Positive Reactions | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | In Situ Hybridization, Fluorescence - Economics - Utilization | en_US |
dc.subject.mesh | Karyotyping | en_US |
dc.subject.mesh | Molecular Diagnostic Techniques | en_US |
dc.subject.mesh | Polymerase Chain Reaction - Economics - Utilization | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Prenatal Diagnosis - Methods | en_US |
dc.title | Rapid aneuploidy screening (FISH or QF-PCR): The changing scene in prenatal diagnosis? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, MHY=rp01701 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1586/14737159.4.3.333 | en_US |
dc.identifier.pmid | 15137900 | - |
dc.identifier.scopus | eid_2-s2.0-2542421711 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-2542421711&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 4 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 333 | en_US |
dc.identifier.epage | 337 | en_US |
dc.identifier.isi | WOS:000221285900007 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Leung, WC=7201504435 | en_US |
dc.identifier.scopusauthorid | Lau, ET=7103086081 | en_US |
dc.identifier.scopusauthorid | Lao, TT=7005722132 | en_US |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_US |
dc.identifier.issnl | 1473-7159 | - |