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- Publisher Website: 10.1111/j.1745-7254.2005.00122.x
- Scopus: eid_2-s2.0-22144470179
- PMID: 15960894
- WOS: WOS:000230442400013
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Article: Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women
Title | Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women |
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Authors | |
Keywords | Association Estrogen receptor α gene Haplotype Menarche Vitamin D receptor gene |
Issue Date | 2005 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html |
Citation | Acta Pharmacologica Sinica, 2005, v. 26 n. 7, p. 860-864 How to Cite? |
Abstract | Aim: To evaluate whether estrogen receptor α(ER-α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women. Methods: A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII, XbaI, and VDR ApaI loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Results: Neither the ER-α gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P>0.10). However, evidence of interaction effects between the two genes were observed: with the aa genotype at the VDR ApaI locus, subjects with haplotype PX at the ER-α gene had, on average, 6 months later onset of menarche than the non-carriers (P=0.01). Conclusion: We found that neither the ER-α gene or the VDR gene had a significant association with the age at menarche individually. However, potential interaction effects between the two genes were observed in Chinese women. ©2005 CPS and SIMM. |
Persistent Identifier | http://hdl.handle.net/10722/181199 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 1.882 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, H | en_US |
dc.contributor.author | Long, JR | en_US |
dc.contributor.author | Li, MX | en_US |
dc.contributor.author | Deng, HW | en_US |
dc.date.accessioned | 2013-02-21T02:02:44Z | - |
dc.date.available | 2013-02-21T02:02:44Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Acta Pharmacologica Sinica, 2005, v. 26 n. 7, p. 860-864 | en_US |
dc.identifier.issn | 1671-4083 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/181199 | - |
dc.description.abstract | Aim: To evaluate whether estrogen receptor α(ER-α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women. Methods: A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII, XbaI, and VDR ApaI loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Results: Neither the ER-α gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P>0.10). However, evidence of interaction effects between the two genes were observed: with the aa genotype at the VDR ApaI locus, subjects with haplotype PX at the ER-α gene had, on average, 6 months later onset of menarche than the non-carriers (P=0.01). Conclusion: We found that neither the ER-α gene or the VDR gene had a significant association with the age at menarche individually. However, potential interaction effects between the two genes were observed in Chinese women. ©2005 CPS and SIMM. | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html | en_US |
dc.relation.ispartof | Acta Pharmacologica Sinica | en_US |
dc.subject | Association | - |
dc.subject | Estrogen receptor α gene | - |
dc.subject | Haplotype | - |
dc.subject | Menarche | - |
dc.subject | Vitamin D receptor gene | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Asian Continental Ancestry Group | en_US |
dc.subject.mesh | China | en_US |
dc.subject.mesh | Estrogen Receptor Alpha - Genetics | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene Frequency | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Menarche - Genetics | en_US |
dc.subject.mesh | Polymorphism, Restriction Fragment Length | en_US |
dc.subject.mesh | Premenopause | en_US |
dc.subject.mesh | Receptors, Calcitriol - Genetics | en_US |
dc.title | Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, MX: mxli@hku.hk | en_US |
dc.identifier.authority | Li, MX=rp01722 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1745-7254.2005.00122.x | en_US |
dc.identifier.pmid | 15960894 | - |
dc.identifier.scopus | eid_2-s2.0-22144470179 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-22144470179&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 26 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 860 | en_US |
dc.identifier.epage | 864 | en_US |
dc.identifier.isi | WOS:000230442400013 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Xu, H=7407450019 | en_US |
dc.identifier.scopusauthorid | Long, JR=7403446542 | en_US |
dc.identifier.scopusauthorid | Li, MX=17135391100 | en_US |
dc.identifier.scopusauthorid | Deng, HW=34568563000 | en_US |
dc.identifier.issnl | 1671-4083 | - |