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- Publisher Website: 10.1016/j.pscychresns.2012.09.010
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Article: Magnetic resonance spectroscopy reveals N-acetylaspartate reduction in hippocampus and cingulate cortex after fear conditioning
Title | Magnetic resonance spectroscopy reveals N-acetylaspartate reduction in hippocampus and cingulate cortex after fear conditioning |
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Authors | |
Keywords | Cingulate Cortex Fear Conditioning Hippocampus Mouse Brain N-Acetylaspartate Proton Magnetic Resonance Spectroscopy |
Issue Date | 2012 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresns |
Citation | Psychiatry Research - Neuroimaging, 2012, v. 204 n. 2-3, p. 178-183 How to Cite? |
Abstract | The fear conditioning in rodents provides a valuable translational tool to investigate the neural basis of learning and memory and potentially the neurobiology of post-traumatic stress disorder (PTSD). Neurobiological changes induced by fear conditioning have largely been examined ex vivo while progressive 'real-time' changes in vivo remain under-explored. Single voxel proton magnetic resonance spectroscopy (1H MRS) of the hippocampus, cingulate cortex and thalamus of adult male C57BL/6N mice (N=12) was performed at 1 day before, 1 day and 1 week after, fear conditioning training using a 7T scanner. N-acetylaspartate (NAA), a marker for neuronal integrity and viability, significantly decreased in the hippocampus at 1 day and 1 week post-conditioning. Significant NAA reduction was also observed in the cingulate cortex at 1 day post-conditioning. These findings of hippocampal NAA decrease indicate reduced neuronal dysfunction and/or neuronal integrity, contributing to the trauma-related PTSD-like symptoms. The neurochemical changes characterized by 1H MRS can shed light on the biochemical mechanisms of learning and memory. Moreover, such information can potentially facilitate prompt intervention for patients with psychiatric disorders. © 2012 Elsevier Ireland Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/182347 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.797 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Zhou, IY | en_US |
dc.contributor.author | Ding, AY | en_US |
dc.contributor.author | Li, Q | en_US |
dc.contributor.author | McAlonan, GM | en_US |
dc.contributor.author | Wu, EX | en_US |
dc.date.accessioned | 2013-04-23T08:19:31Z | - |
dc.date.available | 2013-04-23T08:19:31Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Psychiatry Research - Neuroimaging, 2012, v. 204 n. 2-3, p. 178-183 | en_US |
dc.identifier.issn | 0925-4927 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/182347 | - |
dc.description.abstract | The fear conditioning in rodents provides a valuable translational tool to investigate the neural basis of learning and memory and potentially the neurobiology of post-traumatic stress disorder (PTSD). Neurobiological changes induced by fear conditioning have largely been examined ex vivo while progressive 'real-time' changes in vivo remain under-explored. Single voxel proton magnetic resonance spectroscopy (1H MRS) of the hippocampus, cingulate cortex and thalamus of adult male C57BL/6N mice (N=12) was performed at 1 day before, 1 day and 1 week after, fear conditioning training using a 7T scanner. N-acetylaspartate (NAA), a marker for neuronal integrity and viability, significantly decreased in the hippocampus at 1 day and 1 week post-conditioning. Significant NAA reduction was also observed in the cingulate cortex at 1 day post-conditioning. These findings of hippocampal NAA decrease indicate reduced neuronal dysfunction and/or neuronal integrity, contributing to the trauma-related PTSD-like symptoms. The neurochemical changes characterized by 1H MRS can shed light on the biochemical mechanisms of learning and memory. Moreover, such information can potentially facilitate prompt intervention for patients with psychiatric disorders. © 2012 Elsevier Ireland Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresns | en_US |
dc.relation.ispartof | Psychiatry Research - Neuroimaging | en_US |
dc.rights | NOTICE: this is the author’s version of a work that was accepted for publication in Psychiatry Research - Neuroimaging. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychiatry Research - Neuroimaging, 2012, v. 204 n. 2-3, p. 178-183. DOI: 10.1016/j.pscychresns.2012.09.010 | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Cingulate Cortex | en_US |
dc.subject | Fear Conditioning | en_US |
dc.subject | Hippocampus | en_US |
dc.subject | Mouse Brain | en_US |
dc.subject | N-Acetylaspartate | en_US |
dc.subject | Proton Magnetic Resonance Spectroscopy | en_US |
dc.title | Magnetic resonance spectroscopy reveals N-acetylaspartate reduction in hippocampus and cingulate cortex after fear conditioning | en_US |
dc.type | Article | en_US |
dc.identifier.email | Zhou, IY: izhou@hku.hk | en_US |
dc.identifier.email | McAlonan, GM: mcalonan@hkucc.hku.hk | en_US |
dc.identifier.email | Wu, EX: ewu1@hkucc.hku.hk | en_US |
dc.identifier.authority | Zhou, IY=rp01739 | en_US |
dc.identifier.authority | McAlonan, GM=rp00475 | en_US |
dc.identifier.authority | Wu, EX=rp00193 | en_US |
dc.description.nature | postprint | en_US |
dc.identifier.doi | 10.1016/j.pscychresns.2012.09.010 | en_US |
dc.identifier.pmid | 23137804 | - |
dc.identifier.scopus | eid_2-s2.0-84872379365 | en_US |
dc.identifier.hkuros | 217894 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84872379365&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 204 | en_US |
dc.identifier.issue | 2-3 | en_US |
dc.identifier.spage | 178 | en_US |
dc.identifier.epage | 183 | en_US |
dc.identifier.isi | WOS:000314329200016 | - |
dc.publisher.place | Ireland | en_US |
dc.identifier.scopusauthorid | Zhou, IY=35424838500 | en_US |
dc.identifier.scopusauthorid | Ding, AY=55443036900 | en_US |
dc.identifier.scopusauthorid | Li, Q=36068669600 | en_US |
dc.identifier.scopusauthorid | McAlonan, GM=6603123011 | en_US |
dc.identifier.scopusauthorid | Wu, EX=7202128034 | en_US |
dc.identifier.issnl | 0925-4927 | - |