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Article: A randomized, double-blind, controlled trial of a Chinese herbal formula (Er-Xian decoction) for menopausal symptoms in Hong Kong perimenopausal women

TitleA randomized, double-blind, controlled trial of a Chinese herbal formula (Er-Xian decoction) for menopausal symptoms in Hong Kong perimenopausal women
Authors
KeywordsChinese herbal medicine
Er-Xian decoction
Hot flushes
Menopause
Quality of life
Issue Date2013
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.com
Citation
Menopause, 2013, v. 20 n. 7, p. 767-776 How to Cite?
AbstractObjective: The aim of this study is to investigate the effectiveness and safety of a Chinese herbal formula, Er-Xian decoction (EXD), in the treatment of menopausal symptoms among Hong Kong perimenopausal women. Methods: A randomized, double-blind, controlled trial was conducted for 12 weeks among 108 Hong Kong perimenopausal women who reported Menopause Rating Scale (MRS) total scores of 28 or higher. Posttreatment follow-up was performed 3 months after the intervention. The primary outcome measure was the frequency and severity of hot flushes. The secondary outcome measures included the MRS, the Menopause-Specific Quality of Life questionnaire, and serum hormone levels. Results: Among 108 participants, 101 participants finished the study. EXD significantly reduced the mean (SD) frequency of hot flushes from 5.8 (5.0) to 2.2 (3.0) in the treatment group and from 5.0 (3.8) to 2.4 (2.5) in the placebo group (P = 0.04). The mean (SD) hot flush score was also reduced from 19.6 (6.6) to 4.9 (7.8) in the treatment group and from 16.6 (5.4) to 7.0 (6.4) in the placebo group (P = 0.02). The superiority of EXD to placebo was also observed with greater improvement in the total scores for the MRS (P = 0.03) and the Menopause-Specific Quality of Life questionnaire (P < 0.01). There were no differences in serum hormone levels between the EXD group and the placebo group. There were no serious adverse events, and the safety indices of whole blood counts, renal function, and liver function were within the normal range before and after treatment. Conclusions: The Chinese herbal formula EXD is superior to placebo in reducing the frequency and severity of hot flushes and in improving menopausal symptoms in Hong Kong perimenopausal women. It is well tolerated, with no serious adverse events noted during the study period.
Persistent Identifierhttp://hdl.handle.net/10722/183189
ISSN
2017 Impact Factor: 2.673
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhong, L-
dc.contributor.authorTong, Y-
dc.contributor.authorTang, GWK-
dc.contributor.authorZhang, Z-
dc.contributor.authorChoi, WK-
dc.contributor.authorCheng, SKL-
dc.contributor.authorSze, CW-
dc.contributor.authorKun, W-
dc.contributor.authorLiu, Q-
dc.contributor.authorYu, X-
dc.date.accessioned2013-05-15T01:47:28Z-
dc.date.available2013-05-15T01:47:28Z-
dc.date.issued2013-
dc.identifier.citationMenopause, 2013, v. 20 n. 7, p. 767-776-
dc.identifier.issn1072-3714-
dc.identifier.urihttp://hdl.handle.net/10722/183189-
dc.description.abstractObjective: The aim of this study is to investigate the effectiveness and safety of a Chinese herbal formula, Er-Xian decoction (EXD), in the treatment of menopausal symptoms among Hong Kong perimenopausal women. Methods: A randomized, double-blind, controlled trial was conducted for 12 weeks among 108 Hong Kong perimenopausal women who reported Menopause Rating Scale (MRS) total scores of 28 or higher. Posttreatment follow-up was performed 3 months after the intervention. The primary outcome measure was the frequency and severity of hot flushes. The secondary outcome measures included the MRS, the Menopause-Specific Quality of Life questionnaire, and serum hormone levels. Results: Among 108 participants, 101 participants finished the study. EXD significantly reduced the mean (SD) frequency of hot flushes from 5.8 (5.0) to 2.2 (3.0) in the treatment group and from 5.0 (3.8) to 2.4 (2.5) in the placebo group (P = 0.04). The mean (SD) hot flush score was also reduced from 19.6 (6.6) to 4.9 (7.8) in the treatment group and from 16.6 (5.4) to 7.0 (6.4) in the placebo group (P = 0.02). The superiority of EXD to placebo was also observed with greater improvement in the total scores for the MRS (P = 0.03) and the Menopause-Specific Quality of Life questionnaire (P < 0.01). There were no differences in serum hormone levels between the EXD group and the placebo group. There were no serious adverse events, and the safety indices of whole blood counts, renal function, and liver function were within the normal range before and after treatment. Conclusions: The Chinese herbal formula EXD is superior to placebo in reducing the frequency and severity of hot flushes and in improving menopausal symptoms in Hong Kong perimenopausal women. It is well tolerated, with no serious adverse events noted during the study period.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.com-
dc.relation.ispartofMenopause-
dc.rightsThis is a non-final version of an article published in final form in Menopause-
dc.subjectChinese herbal medicine-
dc.subjectEr-Xian decoction-
dc.subjectHot flushes-
dc.subjectMenopause-
dc.subjectQuality of life-
dc.titleA randomized, double-blind, controlled trial of a Chinese herbal formula (Er-Xian decoction) for menopausal symptoms in Hong Kong perimenopausal women-
dc.typeArticle-
dc.identifier.emailZhong, L: ldzhong@hku.hk-
dc.identifier.emailTong, Y: tongyao@hku.hk-
dc.identifier.emailTang, GWK: gwktang@hkucc.hku.hk-
dc.identifier.emailZhang, Z: zhangzj@hkucc.hku.hk-
dc.identifier.emailChoi, WK: wkchoi@hkucc.hku.hk-
dc.identifier.emailSze, CW: stephens@hku.hk-
dc.identifier.emailKun, W: kunwai@hku.hk-
dc.identifier.emailLiu, Q: qingliu@hkusua.hku.hk-
dc.identifier.emailYu, X: yuxb@hku.hk-
dc.identifier.authorityTong, Y=rp00509-
dc.identifier.authorityTang, GWK=rp00328-
dc.identifier.authorityZhang, Z=rp01297-
dc.identifier.authoritySze, CW=rp00514-
dc.identifier.authorityKun, W=rp01343-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/GME.0b013e31827cd3dd-
dc.identifier.pmid23793167-
dc.identifier.scopuseid_2-s2.0-84879927281-
dc.identifier.hkuros214256-
dc.identifier.volume20-
dc.identifier.issue7-
dc.identifier.spage767-
dc.identifier.epage776-
dc.identifier.isiWOS:000330460900012-
dc.publisher.placeUnited States-

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