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- Publisher Website: 10.1074/mcp.O112.019851
- Scopus: eid_2-s2.0-84887098104
- PMID: 23924514
- WOS: WOS:000328816000029
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Article: ProteoMirExpress: inferring microRNA and protein-centered regulatory networks from high-throughput proteomic and mRNA expression data
Title | ProteoMirExpress: inferring microRNA and protein-centered regulatory networks from high-throughput proteomic and mRNA expression data |
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Authors | |
Issue Date | 2013 |
Publisher | American Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.mcponline.org/ |
Citation | Molecular and Cellular Proteomics, 2013, v. 12 n. 11, p. 3379-3387 How to Cite? |
Abstract | MicroRNAs (miRNAs) regulate gene expression through translational repression and RNA degradation. Recently developed high-throughput proteomic methods measure gene expression changes at protein level and therefore can reveal the direct effects of miRNAs' translational repression. Here, we present a web server, ProteoMir- Express, that integrates proteomic and mRNA expression data together to infer miRNA-centered regulatory networks. With both types of high-throughput data from the users, ProteoMirExpress is able to discover not only miRNA targets that have decreased mRNA, but also subgroups of targets with suppressed proteins whose mRNAs are not significantly changed or with decreased mRNA whose proteins are not significantly changed, which are usually ignored by most current methods. Furthermore, both direct and indirect targets of miRNAs can be detected. Therefore, ProteoMirExpress provides more comprehensive miRNA-centered regulatory networks. We used several published data to assess the quality of our inferred networks and prove the value of our server. ProteoMirExpress is available online, with free access to academic users. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/185601 |
ISSN | 2020 Impact Factor: 5.911 2023 SCImago Journal Rankings: 2.348 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | QIN, J | - |
dc.contributor.author | LI, MJ | - |
dc.contributor.author | WANG, P | - |
dc.contributor.author | Wong, NS | - |
dc.contributor.author | Wong, MP | - |
dc.contributor.author | Xia, Z | - |
dc.contributor.author | Tsao, GSW | - |
dc.contributor.author | Zhang, MQ | - |
dc.contributor.author | Wang, JJ | - |
dc.date.accessioned | 2013-08-20T11:33:42Z | - |
dc.date.available | 2013-08-20T11:33:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Molecular and Cellular Proteomics, 2013, v. 12 n. 11, p. 3379-3387 | - |
dc.identifier.issn | 1535-9476 | - |
dc.identifier.uri | http://hdl.handle.net/10722/185601 | - |
dc.description.abstract | MicroRNAs (miRNAs) regulate gene expression through translational repression and RNA degradation. Recently developed high-throughput proteomic methods measure gene expression changes at protein level and therefore can reveal the direct effects of miRNAs' translational repression. Here, we present a web server, ProteoMir- Express, that integrates proteomic and mRNA expression data together to infer miRNA-centered regulatory networks. With both types of high-throughput data from the users, ProteoMirExpress is able to discover not only miRNA targets that have decreased mRNA, but also subgroups of targets with suppressed proteins whose mRNAs are not significantly changed or with decreased mRNA whose proteins are not significantly changed, which are usually ignored by most current methods. Furthermore, both direct and indirect targets of miRNAs can be detected. Therefore, ProteoMirExpress provides more comprehensive miRNA-centered regulatory networks. We used several published data to assess the quality of our inferred networks and prove the value of our server. ProteoMirExpress is available online, with free access to academic users. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.language | eng | - |
dc.publisher | American Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.mcponline.org/ | - |
dc.relation.ispartof | Molecular and Cellular Proteomics | - |
dc.rights | Molecular and Cellular Proteomics. Copyright © American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.rights | This research was originally published in [Journal Name]. Author(s). Title. Journal Name. Year. Vol:pp-pp. © the American Society for Biochemistry and Molecular Biology | - |
dc.title | ProteoMirExpress: inferring microRNA and protein-centered regulatory networks from high-throughput proteomic and mRNA expression data | - |
dc.type | Article | - |
dc.identifier.email | Wong, NS: nswong@hku.hk | - |
dc.identifier.email | Wong, MP: mwpik@hku.hk | - |
dc.identifier.email | Xia, Z: zyxia@hkucc.hku.hk | - |
dc.identifier.email | Tsao, GSW: gswtsao@hku.hk | - |
dc.identifier.email | Wang, JJ: junwen@hku.hk | - |
dc.identifier.authority | Wong, NS=rp00340 | - |
dc.identifier.authority | Wong, MP=rp00348 | - |
dc.identifier.authority | Xia, Z=rp00532 | - |
dc.identifier.authority | Tsao, GSW=rp00399 | - |
dc.identifier.authority | Wang, JJ=rp00280 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1074/mcp.O112.019851 | - |
dc.identifier.pmid | 23924514 | - |
dc.identifier.pmcid | PMC3820948 | - |
dc.identifier.scopus | eid_2-s2.0-84887098104 | - |
dc.identifier.hkuros | 220849 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 3379 | - |
dc.identifier.epage | 3387 | - |
dc.identifier.isi | WOS:000328816000029 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1535-9476 | - |