File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1177/1076029612466284
- Scopus: eid_2-s2.0-84899032500
- PMID: 23242413
- WOS: WOS:000333743400004
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Cyclooxygenase-1 mediated platelet reactivity in young male smokers
Title | Cyclooxygenase-1 mediated platelet reactivity in young male smokers |
---|---|
Authors | |
Keywords | Atherosclerosis Platelet dysfunction Platelet function Vascular disease |
Issue Date | 2012 |
Publisher | Sage Publications, Inc. The Journal's web site is located at http://cat.sagepub.com |
Citation | Clinical and Applied Thrombosis/Hemostasis, 2012, v. 20 n. 4, p. 371-377 How to Cite? |
Abstract | Background: The purpose of this study is to investigate the acute and chronic effects of cigarette smoking on cyclooxygenase- 1(COX-1)-mediated platelet reactivity among cigarette smokers. Methods: The levels of collagen-induced platelet aggregation, platelet COX-1 activity, and expressions were compared between smokers and age-matched nonsmokers. In smokers, the acute effects of cigarette smoking were assessed by repeating these measurements an hour after smoking. Results: Twenty-five smokers and age-matched nonsmokers (all men; mean age, 29 years) were studied. Collagen-induced platelet aggregation and plasma/urinary thromboxane B2 (TXB2) and 11-dehydroxythromboxane B2 levels were higher in cigarette smokers compared to nonsmokers. Greater expression of platelet COX-1 was observed in smokers than in nonsmokers. Among smokers, collagen-induced platelet aggregation correlated positively with platelet volume and circulating nicotine and cotinine concentrations. The levels of plasma/urinary TXB2 were significantly increased an hour after cigarette smoking. Conclusion: Cigarette smoking aggravates COX-1-mediated platelet reactivity in young, otherwise healthy, smoking men. |
Persistent Identifier | http://hdl.handle.net/10722/191796 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.633 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Loke, WM | en_US |
dc.contributor.author | Lam, KMS | en_US |
dc.contributor.author | Lee, CYJ | en_US |
dc.contributor.author | Chong, WL | en_US |
dc.contributor.author | Soh, EC | en_US |
dc.contributor.author | Huang, H | en_US |
dc.contributor.author | Looi, WF | en_US |
dc.contributor.author | Quek, AML | en_US |
dc.contributor.author | Lim, ECH | en_US |
dc.contributor.author | Seet, RCS | en_US |
dc.date.accessioned | 2013-10-15T07:24:35Z | - |
dc.date.available | 2013-10-15T07:24:35Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Clinical and Applied Thrombosis/Hemostasis, 2012, v. 20 n. 4, p. 371-377 | en_US |
dc.identifier.issn | 1076-0296 | - |
dc.identifier.uri | http://hdl.handle.net/10722/191796 | - |
dc.description.abstract | Background: The purpose of this study is to investigate the acute and chronic effects of cigarette smoking on cyclooxygenase- 1(COX-1)-mediated platelet reactivity among cigarette smokers. Methods: The levels of collagen-induced platelet aggregation, platelet COX-1 activity, and expressions were compared between smokers and age-matched nonsmokers. In smokers, the acute effects of cigarette smoking were assessed by repeating these measurements an hour after smoking. Results: Twenty-five smokers and age-matched nonsmokers (all men; mean age, 29 years) were studied. Collagen-induced platelet aggregation and plasma/urinary thromboxane B2 (TXB2) and 11-dehydroxythromboxane B2 levels were higher in cigarette smokers compared to nonsmokers. Greater expression of platelet COX-1 was observed in smokers than in nonsmokers. Among smokers, collagen-induced platelet aggregation correlated positively with platelet volume and circulating nicotine and cotinine concentrations. The levels of plasma/urinary TXB2 were significantly increased an hour after cigarette smoking. Conclusion: Cigarette smoking aggravates COX-1-mediated platelet reactivity in young, otherwise healthy, smoking men. | - |
dc.language | eng | en_US |
dc.publisher | Sage Publications, Inc. The Journal's web site is located at http://cat.sagepub.com | en_US |
dc.relation.ispartof | Clinical and Applied Thrombosis/Hemostasis | en_US |
dc.rights | Clinical and Applied Thrombosis/Hemostasis. Copyright © Sage Publications, Inc. | en_US |
dc.subject | Atherosclerosis | - |
dc.subject | Platelet dysfunction | - |
dc.subject | Platelet function | - |
dc.subject | Vascular disease | - |
dc.title | Cyclooxygenase-1 mediated platelet reactivity in young male smokers | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, CYJ: jettylee@hku.hk | en_US |
dc.identifier.authority | Lee, CYJ=rp01511 | en_US |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1177/1076029612466284 | - |
dc.identifier.pmid | 23242413 | - |
dc.identifier.scopus | eid_2-s2.0-84899032500 | - |
dc.identifier.hkuros | 225507 | en_US |
dc.identifier.hkuros | 213782 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 371 | - |
dc.identifier.epage | 377 | - |
dc.identifier.isi | WOS:000333743400004 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1076-0296 | - |