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Article: Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair

TitleMesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair
Authors
KeywordsDisc degeneration
Mesenchymal stem cells/multipotent stromal cells
Fibrosis
Collagen fibril
Matrix metalloproteinase 12
Issue Date2014
PublisherAlphaMed Press, Inc. The Journal's web site is located at http://www.stemcells.com
Citation
Stem Cells, 2014, v. 32 n. 8, p. 2164-2177 How to Cite?
AbstractIntervertebral disc degeneration is associated with back pain and radiculopathy which, being a leading cause of disability, seriously affects the quality of life and presents a hefty burden to society. There is no effective intervention for the disease and the aetiology remains unclear. Here, we show that disc degeneration exhibits features of fibrosis in humans and confirmed this in a puncture-induced disc degeneration (PDD) model in rabbit. Implantation of bone marrow-derived mesenchymal stem cells (MSCs) to PDD discs can inhibit fibrosis in the nucleus pulposus with effective preservation of mechanical properties and overall spinal function. We showed that the presence of MSCs can suppress abnormal deposition of collagen I in the nucleus pulposus, modulating profibrotic mediators MMP12 and HSP47, thus reducing collagen aggregation and maintaining proper fibrillar properties and function. As collagen fibrils can regulate progenitor cell activities, our finding provides new insight to the limited self-repair capability of the intervertebral disc and importantly the mechanism by which MSCs may potentiate tissue regeneration through regulating collagen fibrillogenesis in the context of fibrotic diseases.
Persistent Identifierhttp://hdl.handle.net/10722/198461
ISSN
2019 Impact Factor: 6.022
2015 SCImago Journal Rankings: 3.438

 

DC FieldValueLanguage
dc.contributor.authorLeung, VYL-
dc.contributor.authorAladin Kaderbatcha, DM-
dc.contributor.authorLv, F-
dc.contributor.authorTam, V-
dc.contributor.authorSun, Y-
dc.contributor.authorLau, RYC-
dc.contributor.authorHung, SC-
dc.contributor.authorNgan, AHW-
dc.contributor.authorWu, EX-
dc.contributor.authorLuk, KDK-
dc.contributor.authorLu, WW-
dc.contributor.authorMasuda, K-
dc.contributor.authorChan, D-
dc.date.accessioned2014-07-07T07:00:31Z-
dc.date.available2014-07-07T07:00:31Z-
dc.date.issued2014-
dc.identifier.citationStem Cells, 2014, v. 32 n. 8, p. 2164-2177-
dc.identifier.issn1066-5099-
dc.identifier.urihttp://hdl.handle.net/10722/198461-
dc.description.abstractIntervertebral disc degeneration is associated with back pain and radiculopathy which, being a leading cause of disability, seriously affects the quality of life and presents a hefty burden to society. There is no effective intervention for the disease and the aetiology remains unclear. Here, we show that disc degeneration exhibits features of fibrosis in humans and confirmed this in a puncture-induced disc degeneration (PDD) model in rabbit. Implantation of bone marrow-derived mesenchymal stem cells (MSCs) to PDD discs can inhibit fibrosis in the nucleus pulposus with effective preservation of mechanical properties and overall spinal function. We showed that the presence of MSCs can suppress abnormal deposition of collagen I in the nucleus pulposus, modulating profibrotic mediators MMP12 and HSP47, thus reducing collagen aggregation and maintaining proper fibrillar properties and function. As collagen fibrils can regulate progenitor cell activities, our finding provides new insight to the limited self-repair capability of the intervertebral disc and importantly the mechanism by which MSCs may potentiate tissue regeneration through regulating collagen fibrillogenesis in the context of fibrotic diseases.-
dc.languageeng-
dc.publisherAlphaMed Press, Inc. The Journal's web site is located at http://www.stemcells.com-
dc.relation.ispartofStem Cells-
dc.subjectDisc degeneration-
dc.subjectMesenchymal stem cells/multipotent stromal cells-
dc.subjectFibrosis-
dc.subjectCollagen fibril-
dc.subjectMatrix metalloproteinase 12-
dc.titleMesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair-
dc.typeArticle-
dc.identifier.emailLeung, VYL: vicleung@hku.hk-
dc.identifier.emailAladin Kaderbatcha, DM: darwesh@hku.hk-
dc.identifier.emailLv, F: fengjuan@hku.hk-
dc.identifier.emailTam, V: vivtam@hku.hk-
dc.identifier.emailNgan, AHW: hwngan@hkucc.hku.hk-
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hk-
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hk-
dc.identifier.emailLu, WW: wwlu@hku.hk-
dc.identifier.emailChan, D: chand@hku.hk-
dc.identifier.authorityLeung, VYL=rp01764-
dc.identifier.authorityNgan, AHW=rp00225-
dc.identifier.authorityWu, EX=rp00193-
dc.identifier.authorityLuk, KDK=rp00333-
dc.identifier.authorityLu, WW=rp00411-
dc.identifier.authorityChan, D=rp00540-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/stem.1717-
dc.identifier.pmid24737495-
dc.identifier.scopuseid_2-s2.0-84904433560-
dc.identifier.hkuros230106-
dc.identifier.hkuros305258-
dc.identifier.volume32-
dc.identifier.issue8-
dc.identifier.spage2164-
dc.identifier.epage2177-
dc.publisher.placeUnited States-

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