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- Publisher Website: 10.1021/ja5102739
- Scopus: eid_2-s2.0-84921830184
- WOS: WOS:000348690100023
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Article: Palladium(II)-Catalyzed Intramolecular Tandem Aminoalkylation via Divergent C(sp3)–H Functionalization
Title | Palladium(II)-Catalyzed Intramolecular Tandem Aminoalkylation via Divergent C(sp3)–H Functionalization |
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Authors | |
Issue Date | 2014 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html |
Citation | Journal of the American Chemical Society, 2014, v. 137, p. 1130-1135 How to Cite? |
Abstract | We have developed a Pd(II)-catalyzed oxidative tandem aminoalkylation via divergent C(sp3)–H functionalization, affording three- and five-membered-ring fused indolines in good yields under two optimized conditions, respectively. The mechanism studies have indicated that the benzylic C–H cleavage involved in the former transformation is the rate-determining step, while the cleavage of amide α-C–H in the latter is not. This is the first example of a Pd-catalyzed tandem reaction involving C(sp3)–H activation without the employment of prefunctionalized reagents (e.g., halogenated and boron reagents) and directing groups, representing a green and economic protocol for the construction of N-containing heterocycles. |
Persistent Identifier | http://hdl.handle.net/10722/211711 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | DU, W | - |
dc.contributor.author | Gu, Q | - |
dc.contributor.author | LI, Z | - |
dc.contributor.author | Yang, D | - |
dc.date.accessioned | 2015-07-21T02:08:39Z | - |
dc.date.available | 2015-07-21T02:08:39Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2014, v. 137, p. 1130-1135 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/211711 | - |
dc.description.abstract | We have developed a Pd(II)-catalyzed oxidative tandem aminoalkylation via divergent C(sp3)–H functionalization, affording three- and five-membered-ring fused indolines in good yields under two optimized conditions, respectively. The mechanism studies have indicated that the benzylic C–H cleavage involved in the former transformation is the rate-determining step, while the cleavage of amide α-C–H in the latter is not. This is the first example of a Pd-catalyzed tandem reaction involving C(sp3)–H activation without the employment of prefunctionalized reagents (e.g., halogenated and boron reagents) and directing groups, representing a green and economic protocol for the construction of N-containing heterocycles. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.title | Palladium(II)-Catalyzed Intramolecular Tandem Aminoalkylation via Divergent C(sp3)–H Functionalization | - |
dc.type | Article | - |
dc.identifier.email | Gu, Q: gqsady3e@hku.hk | - |
dc.identifier.email | Yang, D: yangdan@hku.hk | - |
dc.identifier.authority | Yang, D=rp00825 | - |
dc.identifier.doi | 10.1021/ja5102739 | - |
dc.identifier.scopus | eid_2-s2.0-84921830184 | - |
dc.identifier.hkuros | 244936 | - |
dc.identifier.volume | 137 | - |
dc.identifier.spage | 1130 | - |
dc.identifier.epage | 1135 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.isi | WOS:000348690100023 | - |
dc.identifier.issnl | 0002-7863 | - |