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- Publisher Website: 10.1097/00005176-198901000-00009
- Scopus: eid_2-s2.0-0024478263
- PMID: 2567346
- WOS: WOS:A1989T010800009
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Article: The Use Of H2-Receptor Antagonist In The Treatment Of Peptic Ulcer Disease In Children
Title | The Use Of H2-Receptor Antagonist In The Treatment Of Peptic Ulcer Disease In Children |
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Authors | |
Keywords | Childhood peptic ulcer Cimetidine H2-Antagonist Ranitidine Upper gastrointestinal endoscopy |
Issue Date | 1989 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.jpgn.org |
Citation | Journal Of Pediatric Gastroenterology And Nutrition, 1989, v. 8 n. 1, p. 41-46 How to Cite? |
Abstract | We Report Our 20 Years' Experience On The Management Of 78 Children With Primary Chronic Peptic Ulcer, Giving Special Emphasis To The Recent 32 Patients (29 Duodenal Ulcer, 3 Gastric Ulcer) Who Received H2-Antagonist Therapy Guided By Endoscopic Surveillance. The Most Striking Observation Was The Marked Decrease In The Incidence Of 'Failed Medical Treatment Necessitating Surgery' From 34.8% (16/46) In The Pre-H2-Antagonist Era To 3.1% (1/32) In The H2-Antagonist Era. H2 Antagonist Was Uniformly Well Tolerated And Without Side-Effects. In 29 Patients With Duodenal Ulcer, A 6-Week Therapeutic Course Resulted In Complete Ulcer Healing In 22 (75.9%). Further Therapeutic Courses Resulted In Complete Ulcer Healing In Four Additional Patients (13.8%). There Was Only Partial Ulcer Healing In Two Patients (6.9%) And Non-Healing In One Patient (3.49%). There Were 11 Episodes Of Recurrence In Nine Patients (Symptomatic 5, Asymptomatic 6). Recurrence Was More Frequent When Nocturnal-Dose Maintenance Was Not Given (8/11 Recurrences). All Recurences Responded Satisfactorily To Further H2-Antagonist Therapy. Patients With Gastric Ulcer Responded Even More Favorably, All Three Healing Completely With A Single Therapeutic Course And Not Requiring Maintenance Therapy. We Conclude That H2-Antagonist Is Safe And Highly Effective For Healing Peptic Ulcer In Children. For Duodenal Ulcer, Maintenance Therapy Ensures A Satisfactory Remission Rate. |
Persistent Identifier | http://hdl.handle.net/10722/220813 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.837 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tam, PKH | en_US |
dc.contributor.author | Saing, H | en_US |
dc.date.accessioned | 2015-10-19T04:08:39Z | - |
dc.date.available | 2015-10-19T04:08:39Z | - |
dc.date.issued | 1989 | - |
dc.identifier.citation | Journal Of Pediatric Gastroenterology And Nutrition, 1989, v. 8 n. 1, p. 41-46 | en_US |
dc.identifier.issn | 0277-2116 | - |
dc.identifier.uri | http://hdl.handle.net/10722/220813 | - |
dc.description.abstract | We Report Our 20 Years' Experience On The Management Of 78 Children With Primary Chronic Peptic Ulcer, Giving Special Emphasis To The Recent 32 Patients (29 Duodenal Ulcer, 3 Gastric Ulcer) Who Received H2-Antagonist Therapy Guided By Endoscopic Surveillance. The Most Striking Observation Was The Marked Decrease In The Incidence Of 'Failed Medical Treatment Necessitating Surgery' From 34.8% (16/46) In The Pre-H2-Antagonist Era To 3.1% (1/32) In The H2-Antagonist Era. H2 Antagonist Was Uniformly Well Tolerated And Without Side-Effects. In 29 Patients With Duodenal Ulcer, A 6-Week Therapeutic Course Resulted In Complete Ulcer Healing In 22 (75.9%). Further Therapeutic Courses Resulted In Complete Ulcer Healing In Four Additional Patients (13.8%). There Was Only Partial Ulcer Healing In Two Patients (6.9%) And Non-Healing In One Patient (3.49%). There Were 11 Episodes Of Recurrence In Nine Patients (Symptomatic 5, Asymptomatic 6). Recurrence Was More Frequent When Nocturnal-Dose Maintenance Was Not Given (8/11 Recurrences). All Recurences Responded Satisfactorily To Further H2-Antagonist Therapy. Patients With Gastric Ulcer Responded Even More Favorably, All Three Healing Completely With A Single Therapeutic Course And Not Requiring Maintenance Therapy. We Conclude That H2-Antagonist Is Safe And Highly Effective For Healing Peptic Ulcer In Children. For Duodenal Ulcer, Maintenance Therapy Ensures A Satisfactory Remission Rate. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.jpgn.org | en_US |
dc.relation.ispartof | Journal Of Pediatric Gastroenterology And Nutrition | en_US |
dc.subject | Childhood peptic ulcer | - |
dc.subject | Cimetidine | - |
dc.subject | H2-Antagonist | - |
dc.subject | Ranitidine | - |
dc.subject | Upper gastrointestinal endoscopy | - |
dc.title | The Use Of H2-Receptor Antagonist In The Treatment Of Peptic Ulcer Disease In Children | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tam, PKH:paultam@hkucc.hku.hk | - |
dc.identifier.authority | Tam, PKH=rp00060 | - |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00005176-198901000-00009 | - |
dc.identifier.pmid | 2567346 | - |
dc.identifier.scopus | eid_2-s2.0-0024478263 | - |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 41 | - |
dc.identifier.epage | 46 | - |
dc.identifier.isi | WOS:A1989T010800009 | - |
dc.identifier.issnl | 0277-2116 | - |