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Article: p85α neomorphic mutants: splitting away from the canonical path

Titlep85α neomorphic mutants: splitting away from the canonical path
Authors
Cheung, WTLMills, GB
KeywordsMAPK
mutation
neomorph
p85a
PI3K
PIK3R1
Issue Date2015
PublisherTaylor & Francis Inc.. The Journal's web site is located at http://www.tandfonline.com/kmco
Citation
Molecular & Cellular Oncology, 2015, v. 2 n. 4, p. Article no. e983388 How to Cite?
DOI: http://dx.doi.org/10.4161/23723556.2014.983388
AbstractPIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.
Persistent Identifierhttp://hdl.handle.net/10722/225117
ISI Accession Number ID
WOS:000218570900039

 

DC FieldValueLanguage
dc.contributor.authorCheung, WTL-
dc.contributor.authorMills, GB-
dc.date.accessioned2016-04-22T01:22:07Z-
dc.date.available2016-04-22T01:22:07Z-
dc.date.issued2015-
dc.identifier.citationMolecular & Cellular Oncology, 2015, v. 2 n. 4, p. Article no. e983388-
dc.identifier.urihttp://hdl.handle.net/10722/225117-
dc.description.abstractPIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.-
dc.languageeng-
dc.publisherTaylor & Francis Inc.. The Journal's web site is located at http://www.tandfonline.com/kmco-
dc.relation.ispartofMolecular & Cellular Oncology-
dc.subjectMAPK-
dc.subjectmutation-
dc.subjectneomorph-
dc.subjectp85a-
dc.subjectPI3K-
dc.subjectPIK3R1-
dc.titlep85α neomorphic mutants: splitting away from the canonical path-
dc.typeArticle-
dc.identifier.emailCheung, WTL: lydiacwt@hku.hk-
dc.identifier.authorityCheung, WTL=rp02137-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4161/23723556.2014.983388-
dc.identifier.scopuseid_2-s2.0-85051533421-
dc.identifier.volume2-
dc.identifier.issue4-
dc.identifier.spageArticle no. e983388-
dc.identifier.epageArticle no. e983388-
dc.identifier.eissn2372-3556-
dc.identifier.isiWOS:000218570900039-
dc.publisher.placeUnited States-
dc.identifier.issnl2372-3556-

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