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Article: Medication safety research by observational study design

TitleMedication safety research by observational study design
Authors
KeywordsMethodology
Observational study
Pharmacoepidemiology
Issue Date2016
PublisherSpringer Netherlands. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0928-1231
Citation
International Journal of Clinical Pharmacy, 2016, v. 38 n. 3, p. 676-684 How to Cite?
AbstractObservational studies have been recognised to be essential for investigating the safety profile of medications. Numerous observational studies have been conducted on the platform of large population databases, which provide adequate sample size and follow-up length to detect infrequent and/or delayed clinical outcomes. Cohort and case–control are well-accepted traditional methodologies for hypothesis testing, while within-individual study designs are developing and evolving, addressing previous known methodological limitations to reduce confounding and bias. Respective examples of observational studies of different study designs using medical databases are shown. Methodology characteristics, study assumptions, strengths and weaknesses of each method are discussed in this review.
Persistent Identifierhttp://hdl.handle.net/10722/225647
ISSN
2019 Impact Factor: 1.616
2015 SCImago Journal Rankings: 0.575
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLao, S-
dc.contributor.authorChui, SLC-
dc.contributor.authorMan, KCK-
dc.contributor.authorLau, CY-
dc.contributor.authorChan, EW-
dc.contributor.authorWong, ICK-
dc.date.accessioned2016-05-20T08:09:44Z-
dc.date.available2016-05-20T08:09:44Z-
dc.date.issued2016-
dc.identifier.citationInternational Journal of Clinical Pharmacy, 2016, v. 38 n. 3, p. 676-684-
dc.identifier.issn2210-7703-
dc.identifier.urihttp://hdl.handle.net/10722/225647-
dc.description.abstractObservational studies have been recognised to be essential for investigating the safety profile of medications. Numerous observational studies have been conducted on the platform of large population databases, which provide adequate sample size and follow-up length to detect infrequent and/or delayed clinical outcomes. Cohort and case–control are well-accepted traditional methodologies for hypothesis testing, while within-individual study designs are developing and evolving, addressing previous known methodological limitations to reduce confounding and bias. Respective examples of observational studies of different study designs using medical databases are shown. Methodology characteristics, study assumptions, strengths and weaknesses of each method are discussed in this review.-
dc.languageeng-
dc.publisherSpringer Netherlands. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0928-1231-
dc.relation.ispartofInternational Journal of Clinical Pharmacy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectMethodology-
dc.subjectObservational study-
dc.subjectPharmacoepidemiology-
dc.titleMedication safety research by observational study design-
dc.typeArticle-
dc.identifier.emailChui, SLC: cslchui@hku.hk-
dc.identifier.emailMan, KCK: mkckth@hku.hk-
dc.identifier.emailChan, EW: ewchan@hku.hk-
dc.identifier.emailWong, ICK: wongick@hku.hk-
dc.identifier.authorityChui, SLC=rp02527-
dc.identifier.authorityChan, EW=rp01587-
dc.identifier.authorityWong, ICK=rp01480-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s11096-016-0285-6-
dc.identifier.pmid27003827-
dc.identifier.pmcidPMC4909784-
dc.identifier.scopuseid_2-s2.0-84961815087-
dc.identifier.hkuros258108-
dc.identifier.volume38-
dc.identifier.issue3-
dc.identifier.spage676-
dc.identifier.epage684-
dc.identifier.isiWOS:000378771600013-
dc.publisher.placeNetherlands-

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