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Article: Aptamer photoregulation in vivo

TitleAptamer photoregulation in vivo
Authors
KeywordsAptamer
Light triggering
Cancer targeting
Issue Date2014
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2014, v. 111, n. 48, p. 17099-17103 How to Cite?
AbstractThe in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was prevented by hybridizing the aptamer to a photo-labile complementary oligonucleotide. Upon irradiation at the tumor site, the aptamer was liberated, leading to prolonged intratumoral retention. The relative distribution of the aptamer to the liver and kidney was also significantly decreased, compared to that of the free aptamer.
Persistent Identifierhttp://hdl.handle.net/10722/236723
ISSN
2017 Impact Factor: 9.504
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Lele-
dc.contributor.authorTong, Rong-
dc.contributor.authorChu, Hunghao-
dc.contributor.authorWang, Weiping-
dc.contributor.authorLanger, Robert-
dc.contributor.authorKohane, Daniel S.-
dc.date.accessioned2016-12-02T03:07:29Z-
dc.date.available2016-12-02T03:07:29Z-
dc.date.issued2014-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2014, v. 111, n. 48, p. 17099-17103-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/236723-
dc.description.abstractThe in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was prevented by hybridizing the aptamer to a photo-labile complementary oligonucleotide. Upon irradiation at the tumor site, the aptamer was liberated, leading to prolonged intratumoral retention. The relative distribution of the aptamer to the liver and kidney was also significantly decreased, compared to that of the free aptamer.-
dc.languageeng-
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America-
dc.subjectAptamer-
dc.subjectLight triggering-
dc.subjectCancer targeting-
dc.titleAptamer photoregulation in vivo-
dc.typeArticle-
dc.description.natureLink_to_OA_fulltext-
dc.identifier.doi10.1073/pnas.1420105111-
dc.identifier.pmid25404344-
dc.identifier.scopuseid_2-s2.0-84914169000-
dc.identifier.volume111-
dc.identifier.issue48-
dc.identifier.spage17099-
dc.identifier.epage17103-
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000345920800038-

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