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- Publisher Website: 10.1073/pnas.1420105111
- Scopus: eid_2-s2.0-84914169000
- PMID: 25404344
- WOS: WOS:000345920800038
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Article: Aptamer photoregulation in vivo
Title | Aptamer photoregulation in vivo |
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Authors | |
Keywords | Aptamer Light triggering Cancer targeting |
Issue Date | 2014 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2014, v. 111, n. 48, p. 17099-17103 How to Cite? |
Abstract | The in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was prevented by hybridizing the aptamer to a photo-labile complementary oligonucleotide. Upon irradiation at the tumor site, the aptamer was liberated, leading to prolonged intratumoral retention. The relative distribution of the aptamer to the liver and kidney was also significantly decreased, compared to that of the free aptamer. |
Persistent Identifier | http://hdl.handle.net/10722/236723 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, Lele | - |
dc.contributor.author | Tong, Rong | - |
dc.contributor.author | Chu, Hunghao | - |
dc.contributor.author | Wang, Weiping | - |
dc.contributor.author | Langer, Robert | - |
dc.contributor.author | Kohane, Daniel S. | - |
dc.date.accessioned | 2016-12-02T03:07:29Z | - |
dc.date.available | 2016-12-02T03:07:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2014, v. 111, n. 48, p. 17099-17103 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236723 | - |
dc.description.abstract | The in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was prevented by hybridizing the aptamer to a photo-labile complementary oligonucleotide. Upon irradiation at the tumor site, the aptamer was liberated, leading to prolonged intratumoral retention. The relative distribution of the aptamer to the liver and kidney was also significantly decreased, compared to that of the free aptamer. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.subject | Aptamer | - |
dc.subject | Light triggering | - |
dc.subject | Cancer targeting | - |
dc.title | Aptamer photoregulation in vivo | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.1420105111 | - |
dc.identifier.pmid | 25404344 | - |
dc.identifier.scopus | eid_2-s2.0-84914169000 | - |
dc.identifier.volume | 111 | - |
dc.identifier.issue | 48 | - |
dc.identifier.spage | 17099 | - |
dc.identifier.epage | 17103 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.isi | WOS:000345920800038 | - |
dc.identifier.issnl | 0027-8424 | - |