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- Publisher Website: 10.1021/acs.nanolett.5b01325
- Scopus: eid_2-s2.0-84944339302
- PMID: 26158690
- WOS: WOS:000363003100008
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Article: Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting
Title | Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting |
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Authors | |
Keywords | upconverting micelles shielding phototargeted photoresponsive photocleavage Caged ligands |
Issue Date | 2015 |
Citation | Nano Letters, 2015, v. 15, n. 10, p. 6332-6338 How to Cite? |
Abstract | © 2015 American Chemical Society.High-efficiency upconverted light would be a desirable stimulus for triggered drug delivery. Here we present a general strategy to achieve photoreactions based on triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET). We designed PLA-PEG micellar nanoparticles containing in their cores hydrophobic photosensitizer and annihilator molecules which, when stimulated with green light, would undergo TTA-UC. The upconverted energy was then transferred by FRET to a hydrophobic photocleavable group (DEACM), also in the core. The DEACM was bonded to (and thus inactivated) the cell-binding peptide cyclo-(RGDfK), which was bound to the PLA-PEG chain. Cleavage of DEACM by FRET reactivated the PLA-PEG-bound peptide and allowed it to move from the particle core to the surface. TTA-UC followed by FRET allowed photocontrolled binding of cell adhesion with green light LED irradiation at low irradiance for short periods. These are attractive properties in phototriggered systems. |
Persistent Identifier | http://hdl.handle.net/10722/236724 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 3.411 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Weiping | - |
dc.contributor.author | Liu, Qian | - |
dc.contributor.author | Zhan, Changyou | - |
dc.contributor.author | Barhoumi, Aoune | - |
dc.contributor.author | Yang, Tianshe | - |
dc.contributor.author | Wylie, Ryan G. | - |
dc.contributor.author | Armstrong, Patrick A. | - |
dc.contributor.author | Kohane, Daniel S. | - |
dc.date.accessioned | 2016-12-02T03:07:29Z | - |
dc.date.available | 2016-12-02T03:07:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Nano Letters, 2015, v. 15, n. 10, p. 6332-6338 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236724 | - |
dc.description.abstract | © 2015 American Chemical Society.High-efficiency upconverted light would be a desirable stimulus for triggered drug delivery. Here we present a general strategy to achieve photoreactions based on triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET). We designed PLA-PEG micellar nanoparticles containing in their cores hydrophobic photosensitizer and annihilator molecules which, when stimulated with green light, would undergo TTA-UC. The upconverted energy was then transferred by FRET to a hydrophobic photocleavable group (DEACM), also in the core. The DEACM was bonded to (and thus inactivated) the cell-binding peptide cyclo-(RGDfK), which was bound to the PLA-PEG chain. Cleavage of DEACM by FRET reactivated the PLA-PEG-bound peptide and allowed it to move from the particle core to the surface. TTA-UC followed by FRET allowed photocontrolled binding of cell adhesion with green light LED irradiation at low irradiance for short periods. These are attractive properties in phototriggered systems. | - |
dc.language | eng | - |
dc.relation.ispartof | Nano Letters | - |
dc.subject | upconverting micelles | - |
dc.subject | shielding | - |
dc.subject | phototargeted | - |
dc.subject | photoresponsive | - |
dc.subject | photocleavage | - |
dc.subject | Caged ligands | - |
dc.title | Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.nanolett.5b01325 | - |
dc.identifier.pmid | 26158690 | - |
dc.identifier.scopus | eid_2-s2.0-84944339302 | - |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 6332 | - |
dc.identifier.epage | 6338 | - |
dc.identifier.eissn | 1530-6992 | - |
dc.identifier.isi | WOS:000363003100008 | - |
dc.identifier.issnl | 1530-6984 | - |