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Article: Phototriggered Local Anesthesia
Title | Phototriggered Local Anesthesia |
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Authors | |
Keywords | Phototriggering gold nanorod liposome local anesthesia tetrodotoxin |
Issue Date | 2016 |
Citation | Nano Letters, 2016, v. 16, n. 1, p. 177-181 How to Cite? |
Abstract | © 2015 American Chemical Society.We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain. |
Persistent Identifier | http://hdl.handle.net/10722/236726 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 3.411 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhan, Changyou | - |
dc.contributor.author | Wang, Weiping | - |
dc.contributor.author | McAlvin, James B. | - |
dc.contributor.author | Guo, Shutao | - |
dc.contributor.author | Timko, Brian P. | - |
dc.contributor.author | Santamaria, Claudia | - |
dc.contributor.author | Kohane, Daniel S. | - |
dc.date.accessioned | 2016-12-02T03:07:29Z | - |
dc.date.available | 2016-12-02T03:07:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Nano Letters, 2016, v. 16, n. 1, p. 177-181 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236726 | - |
dc.description.abstract | © 2015 American Chemical Society.We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain. | - |
dc.language | eng | - |
dc.relation.ispartof | Nano Letters | - |
dc.subject | Phototriggering | - |
dc.subject | gold nanorod | - |
dc.subject | liposome | - |
dc.subject | local anesthesia | - |
dc.subject | tetrodotoxin | - |
dc.title | Phototriggered Local Anesthesia | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.nanolett.5b03440 | - |
dc.identifier.scopus | eid_2-s2.0-84957588286 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 177 | - |
dc.identifier.epage | 181 | - |
dc.identifier.eissn | 1530-6992 | - |
dc.identifier.isi | WOS:000368322700028 | - |
dc.identifier.issnl | 1530-6984 | - |