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Article: Phototriggered Local Anesthesia

TitlePhototriggered Local Anesthesia
Authors
KeywordsPhototriggering
gold nanorod
liposome
local anesthesia
tetrodotoxin
Issue Date2016
Citation
Nano Letters, 2016, v. 16, n. 1, p. 177-181 How to Cite?
Abstract© 2015 American Chemical Society.We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain.
Persistent Identifierhttp://hdl.handle.net/10722/236726
ISSN
2017 Impact Factor: 12.08
2015 SCImago Journal Rankings: 9.006
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhan, Changyou-
dc.contributor.authorWang, Weiping-
dc.contributor.authorMcAlvin, James B.-
dc.contributor.authorGuo, Shutao-
dc.contributor.authorTimko, Brian P.-
dc.contributor.authorSantamaria, Claudia-
dc.contributor.authorKohane, Daniel S.-
dc.date.accessioned2016-12-02T03:07:29Z-
dc.date.available2016-12-02T03:07:29Z-
dc.date.issued2016-
dc.identifier.citationNano Letters, 2016, v. 16, n. 1, p. 177-181-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/236726-
dc.description.abstract© 2015 American Chemical Society.We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain.-
dc.languageeng-
dc.relation.ispartofNano Letters-
dc.subjectPhototriggering-
dc.subjectgold nanorod-
dc.subjectliposome-
dc.subjectlocal anesthesia-
dc.subjecttetrodotoxin-
dc.titlePhototriggered Local Anesthesia-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.nanolett.5b03440-
dc.identifier.scopuseid_2-s2.0-84957588286-
dc.identifier.volume16-
dc.identifier.issue1-
dc.identifier.spage177-
dc.identifier.epage181-
dc.identifier.eissn1530-6992-
dc.identifier.isiWOS:000368322700028-

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