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Article: iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy

TitleiPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy
Authors
Keywordsmesenchymal stem cells
anthracyclines
cardiomyopathy
induced pluripotent stem cells
Issue Date2016
PublisherElsevier (Cell Press): OAJ. The Journal's web site is located at http://stemcellreports.cell.com
Citation
Stem Cell Reports, 2016, v. 7, n. 4, p. 749-763 How to Cite?
Abstract© 2016 The AuthorsMesenchymal stem cells (MSCs) can donate mitochondria and rescue anthracycline-induced cardiomyocyte (CM) damage, although the underlying mechanisms remain elusive. We determined that the superior efficiency of mitochondrial transfer by human induced-pluripotent-stem-cell-derived MSCs (iPSC-MSCs) compared with bone marrow-derived MSCs (BM-MSCs) is due to high expression of intrinsic Rho GTPase 1 (MIRO1). Further, due to a higher level of TNFαIP2 expression, iPSC-MSCs are more responsive to tumor necrosis factor alpha (TNF-α)-induced tunneling nanotube (TNT) formation for mitochondrial transfer to CMs, which is regulated via the TNF-α/NF-κB/TNFαIP2 signaling pathway. Inhibition of TNFαIP2 or MIRO1 in iPSC-MSCs reduced the efficiency of mitochondrial transfer and decreased CMs protection. Compared with BM-MSCs, transplantation of iPSC-MSCs into a mouse model of anthracycline-induced cardiomyopathy resulted in more human mitochondrial retention and bioenergetic preservation in heart tissue. Efficacious transfer of mitochondria from iPSC-MSCs to CMs, due to higher MIRO1 expression and responsiveness to TNF-α-induced nanotube formation, effectively attenuates anthracycline-induced CM damage.
Persistent Identifierhttp://hdl.handle.net/10722/238163
ISSN
2019 Impact Factor: 6.032
2015 SCImago Journal Rankings: 5.523
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yuelin-
dc.contributor.authorYu, Zhendong-
dc.contributor.authorJiang, Dan-
dc.contributor.authorLiang, Xiaoting-
dc.contributor.authorLiao, Songyan-
dc.contributor.authorZhang, Zhao-
dc.contributor.authorYue, Wensheng-
dc.contributor.authorLi, Xiang-
dc.contributor.authorChiu, Sin Ming-
dc.contributor.authorChai, Yuet Hung-
dc.contributor.authorLiang, Yingmin-
dc.contributor.authorChow, Yenyen-
dc.contributor.authorHan, Shuo-
dc.contributor.authorXu, Aimin-
dc.contributor.authorTse, Hung Fat-
dc.contributor.authorLian, Qizhou-
dc.date.accessioned2017-02-03T02:13:14Z-
dc.date.available2017-02-03T02:13:14Z-
dc.date.issued2016-
dc.identifier.citationStem Cell Reports, 2016, v. 7, n. 4, p. 749-763-
dc.identifier.issn2213-6711-
dc.identifier.urihttp://hdl.handle.net/10722/238163-
dc.description.abstract© 2016 The AuthorsMesenchymal stem cells (MSCs) can donate mitochondria and rescue anthracycline-induced cardiomyocyte (CM) damage, although the underlying mechanisms remain elusive. We determined that the superior efficiency of mitochondrial transfer by human induced-pluripotent-stem-cell-derived MSCs (iPSC-MSCs) compared with bone marrow-derived MSCs (BM-MSCs) is due to high expression of intrinsic Rho GTPase 1 (MIRO1). Further, due to a higher level of TNFαIP2 expression, iPSC-MSCs are more responsive to tumor necrosis factor alpha (TNF-α)-induced tunneling nanotube (TNT) formation for mitochondrial transfer to CMs, which is regulated via the TNF-α/NF-κB/TNFαIP2 signaling pathway. Inhibition of TNFαIP2 or MIRO1 in iPSC-MSCs reduced the efficiency of mitochondrial transfer and decreased CMs protection. Compared with BM-MSCs, transplantation of iPSC-MSCs into a mouse model of anthracycline-induced cardiomyopathy resulted in more human mitochondrial retention and bioenergetic preservation in heart tissue. Efficacious transfer of mitochondria from iPSC-MSCs to CMs, due to higher MIRO1 expression and responsiveness to TNF-α-induced nanotube formation, effectively attenuates anthracycline-induced CM damage.-
dc.languageeng-
dc.publisherElsevier (Cell Press): OAJ. The Journal's web site is located at http://stemcellreports.cell.com-
dc.relation.ispartofStem Cell Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectmesenchymal stem cells-
dc.subjectanthracyclines-
dc.subjectcardiomyopathy-
dc.subjectinduced pluripotent stem cells-
dc.titleiPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.stemcr.2016.08.009-
dc.identifier.scopuseid_2-s2.0-84992202472-
dc.identifier.hkuros262030-
dc.identifier.hkuros277710-
dc.identifier.volume7-
dc.identifier.issue4-
dc.identifier.spage749-
dc.identifier.epage763-
dc.identifier.isiWOS:000389508600013-
dc.publisher.placeUnited States-
dc.customcontrol.immutablecsl 170206-

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