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Article: One-year Results Of Half- Versus Standard-dose Photodynamic Therapy Combined With Ranibizumab For Polypoidal Choroidal Vasculopathy

TitleOne-year Results Of Half- Versus Standard-dose Photodynamic Therapy Combined With Ranibizumab For Polypoidal Choroidal Vasculopathy
Authors
Issue Date2018
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.retinajournal.com
Citation
Retina, 2018, v. 38 n. 4, p. 725-730 How to Cite?
AbstractPurpose: To explore the efficacy of half-dose verteporfin photodynamic therapy (hd-PDT) and standard-dose photodynamic therapy (sd-PDT), when combined with ranibizumab in the treatment of polypoidal choroidal vasculopathy. Methods: Subjects were allocated to either the hd-PDT arm or the sd-PDT arm. All subjects received an injection of ranibizumab and PDT treatment (dosage according to allocation) at baseline. Subjects were followed up monthly for 12 months, and re-treatment were given at each visit if criteria were met. Results: There were 26 subjects in the hd-PDT arm and 32 in the sd-PDT arm. Overall mean age was 69.3 ± 9.4 years. Baseline demographics and ocular features did not differ significantly between the two arms. Improvement in vision and reduction in central retinal thickness were similar between the two arms. When presenting, visual acuity was better than 20/50 (logarithm of the minimum angle of resolution 0.4), or when there were three or less polyps angiogram, those treated with hd-PDT tended to perform better than those treated with sd-PDT. Conclusion: In general, hd-PDT was able to produce similar results as sd-PDT. Subgroup analysis revealed superior results with hd-PDT when baseline vision was 20/50 or better, or when there were three or less polyps on indocyanine green angiography.
Persistent Identifierhttp://hdl.handle.net/10722/240214
ISSN
2017 Impact Factor: 4.013
2015 SCImago Journal Rankings: 1.912
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YHI-
dc.contributor.authorShi, X-
dc.contributor.authorGangwani, R-
dc.contributor.authorIu, LPL-
dc.contributor.authorFung, NSK-
dc.contributor.authorLi, Q-
dc.contributor.authorNg, LKA-
dc.contributor.authorLi, X-
dc.date.accessioned2017-04-19T08:21:20Z-
dc.date.available2017-04-19T08:21:20Z-
dc.date.issued2018-
dc.identifier.citationRetina, 2018, v. 38 n. 4, p. 725-730-
dc.identifier.issn0275-004X-
dc.identifier.urihttp://hdl.handle.net/10722/240214-
dc.description.abstractPurpose: To explore the efficacy of half-dose verteporfin photodynamic therapy (hd-PDT) and standard-dose photodynamic therapy (sd-PDT), when combined with ranibizumab in the treatment of polypoidal choroidal vasculopathy. Methods: Subjects were allocated to either the hd-PDT arm or the sd-PDT arm. All subjects received an injection of ranibizumab and PDT treatment (dosage according to allocation) at baseline. Subjects were followed up monthly for 12 months, and re-treatment were given at each visit if criteria were met. Results: There were 26 subjects in the hd-PDT arm and 32 in the sd-PDT arm. Overall mean age was 69.3 ± 9.4 years. Baseline demographics and ocular features did not differ significantly between the two arms. Improvement in vision and reduction in central retinal thickness were similar between the two arms. When presenting, visual acuity was better than 20/50 (logarithm of the minimum angle of resolution 0.4), or when there were three or less polyps angiogram, those treated with hd-PDT tended to perform better than those treated with sd-PDT. Conclusion: In general, hd-PDT was able to produce similar results as sd-PDT. Subgroup analysis revealed superior results with hd-PDT when baseline vision was 20/50 or better, or when there were three or less polyps on indocyanine green angiography.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.retinajournal.com-
dc.relation.ispartofRetina-
dc.rightsThis is a non-final version of an article published in final form in (provide complete journal citation)-
dc.titleOne-year Results Of Half- Versus Standard-dose Photodynamic Therapy Combined With Ranibizumab For Polypoidal Choroidal Vasculopathy-
dc.typeArticle-
dc.identifier.emailWong, YHI: wongyhi@hku.hk-
dc.identifier.emailIu, LPL: lawipl@hku.hk-
dc.identifier.emailFung, NSK: nickfung@hku.hk-
dc.identifier.emailLi, Q: qinglee@hku.hk-
dc.identifier.emailNg, LKA: nlk008@hku.hk-
dc.identifier.authorityWong, YHI=rp01467-
dc.identifier.authorityFung, NSK=rp02505-
dc.identifier.authorityLi, Q=rp01741-
dc.identifier.authorityNg, LKA=rp01842-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/IAE.0000000000001614-
dc.identifier.pmid28333878-
dc.identifier.scopuseid_2-s2.0-85015930353-
dc.identifier.hkuros271749-
dc.identifier.volume38-
dc.identifier.issue4-
dc.identifier.spage725-
dc.identifier.epage730-
dc.identifier.isiWOS:000440623400017-
dc.publisher.placeUnited States-

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