File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Subcategorisation: Improved Stratification of Thyroid Nodule with Cytological Results of Atypia of Undetermined Significance
Title | Subcategorisation: Improved Stratification of Thyroid Nodule with Cytological Results of Atypia of Undetermined Significance |
---|---|
Authors | |
Issue Date | 2016 |
Publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ASH |
Citation | The 2016 Conjoint Scientific Congress of The Royal College of Surgeons of Edinburgh and College of Surgeons of Hong Kong (RCSEd/CSHK): Making Wise Choices in Surgery, Hong Kong, 17-18 September 2016. In Surgical Practice, 2016, v. 20 n. Suppl. 2, p. 12-13, abstract no. EFP13 How to Cite? |
Abstract | Aim: According to Bethesda Classification for cytology assessment of thyroid nodule, malignancy rate of 'atypia of undetermined significance' ranged from 5 to 15 %. However, AUS represented a heterogenous group of cytology features and reported rate of malignancy was up to 38%. We aim to subcategorise AUS nodules and determine their malignancy risk.
Methods: 1075 thyroidectomies were performed between January 2013 and September 2015. 783 cytology specimens were obtained preoperatively, in which 158 (20.2%) were AUS. The cytology results were reviewed and subclassified into four subgroups: AUS cannot exclude papillary carcinoma (AUS-PTC), AUS cannot exclude follicular neoplasm (AUS-FN), AUS cannot exclude Hürthle cell neoplasm (AUS-HCN), and AUS not otherwise specified (AUS-NOS). The malignancy risk was determined with final pathology.
Results: In 158 nodules with AUS, 35.4% (56/158) patients had malignant thyroid nodule. However, 11 of them were incidental finding. Therefore, only 45 patients' nodule with AUS was finally diagnosed as malignant. 14.5% (23/158) had repeat FNAC. Repeat cytology was unsatisfactory in 30.4% (7/23), benign in 17.4% (4/23), AUS in 43.4%(10/23), suspicious for malignancy in 8.7% (2/23).
Nodules were subcategorised into AUS-PTC (43/158, 27.2%), AUS-FN (59/158, 37.3%), AUS-HCN (12/158, 7.6%) and AUS-NOS (44/158, 27.8%). Malignancy rate was 34.9% for AUS-PTC (15/43), 23.7% for AUS-FN (14/59), 33.3% for AUS-HCN (4/12) and 27.3% for AUS-NOS (12/44).
Conclusion: Malignancy rate of AUS nodules is higher than previously reported. AUS-PTC has higher risk of malignancy than other subcategories. This suggests distinct cytomorphological feature may better predict malignancy and subcategorisation may have potential clinical implication in guiding management. |
Description | This Suppl. is the Special Issue: RCSEd/CSHK Conjoint Scientific Congress 2016, Making Wise Choices in Surgery, 17–18 September 2016, Aberdeen, Hong Kong Extra Free Paper Session II |
Persistent Identifier | http://hdl.handle.net/10722/243399 |
ISSN | 2023 Impact Factor: 0.3 2023 SCImago Journal Rankings: 0.152 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, GYL | - |
dc.contributor.author | Wong, KP | - |
dc.contributor.author | Chan, MP | - |
dc.contributor.author | Lang, HHB | - |
dc.date.accessioned | 2017-08-25T02:54:20Z | - |
dc.date.available | 2017-08-25T02:54:20Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | The 2016 Conjoint Scientific Congress of The Royal College of Surgeons of Edinburgh and College of Surgeons of Hong Kong (RCSEd/CSHK): Making Wise Choices in Surgery, Hong Kong, 17-18 September 2016. In Surgical Practice, 2016, v. 20 n. Suppl. 2, p. 12-13, abstract no. EFP13 | - |
dc.identifier.issn | 1744-1625 | - |
dc.identifier.uri | http://hdl.handle.net/10722/243399 | - |
dc.description | This Suppl. is the Special Issue: RCSEd/CSHK Conjoint Scientific Congress 2016, Making Wise Choices in Surgery, 17–18 September 2016, Aberdeen, Hong Kong | - |
dc.description | Extra Free Paper Session II | - |
dc.description.abstract | Aim: According to Bethesda Classification for cytology assessment of thyroid nodule, malignancy rate of 'atypia of undetermined significance' ranged from 5 to 15 %. However, AUS represented a heterogenous group of cytology features and reported rate of malignancy was up to 38%. We aim to subcategorise AUS nodules and determine their malignancy risk. Methods: 1075 thyroidectomies were performed between January 2013 and September 2015. 783 cytology specimens were obtained preoperatively, in which 158 (20.2%) were AUS. The cytology results were reviewed and subclassified into four subgroups: AUS cannot exclude papillary carcinoma (AUS-PTC), AUS cannot exclude follicular neoplasm (AUS-FN), AUS cannot exclude Hürthle cell neoplasm (AUS-HCN), and AUS not otherwise specified (AUS-NOS). The malignancy risk was determined with final pathology. Results: In 158 nodules with AUS, 35.4% (56/158) patients had malignant thyroid nodule. However, 11 of them were incidental finding. Therefore, only 45 patients' nodule with AUS was finally diagnosed as malignant. 14.5% (23/158) had repeat FNAC. Repeat cytology was unsatisfactory in 30.4% (7/23), benign in 17.4% (4/23), AUS in 43.4%(10/23), suspicious for malignancy in 8.7% (2/23). Nodules were subcategorised into AUS-PTC (43/158, 27.2%), AUS-FN (59/158, 37.3%), AUS-HCN (12/158, 7.6%) and AUS-NOS (44/158, 27.8%). Malignancy rate was 34.9% for AUS-PTC (15/43), 23.7% for AUS-FN (14/59), 33.3% for AUS-HCN (4/12) and 27.3% for AUS-NOS (12/44). Conclusion: Malignancy rate of AUS nodules is higher than previously reported. AUS-PTC has higher risk of malignancy than other subcategories. This suggests distinct cytomorphological feature may better predict malignancy and subcategorisation may have potential clinical implication in guiding management. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ASH | - |
dc.relation.ispartof | Surgical Practice | - |
dc.title | Subcategorisation: Improved Stratification of Thyroid Nodule with Cytological Results of Atypia of Undetermined Significance | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Wong, KP: kpwongb@hku.hk | - |
dc.identifier.email | Lang, HHB: Blang@hku.hk | - |
dc.identifier.authority | Wong, KP=rp02007 | - |
dc.identifier.authority | Lang, HHB=rp01828 | - |
dc.identifier.doi | 10.1111/1744-1633.12206 | - |
dc.identifier.hkuros | 274408 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | Suppl. 2 | - |
dc.identifier.spage | 12 | - |
dc.identifier.epage | 13 | - |
dc.publisher.place | Australia | - |
dc.identifier.issnl | 1744-1625 | - |