File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Evolution of influenza A(H7N9) viruses from waves I to IV

TitleEvolution of influenza A(H7N9) viruses from waves I to IV
Authors
Issue Date2017
PublisherOxford University Press.
Citation
21st International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology (VEME), Seoul, Korea, 14-19 August 2016. In Virus Evolution, 2017, v. 3 n. Suppl 1, p. pii: vew036.006 How to Cite?
AbstractThe H7N9 influenza virus that emerged in East China in early 2013 has caused 736 human infections with a fatality rate of 38.5%, through four outbreak waves. Our previous studies revealed that this virus was generated by reassortment between viruses from wild bird H7 and N9 viruses (surface genes) and poultry H9N2 viruses (internal genes), and that while the H7N9 wave I viruses had highly similar surface genes, the surface genes of the wave II viruses developed into regionally distinct clades. The H7N9 viruses continued to reassort with different H9N2 viruses to obtain internal gene segments, thereby generating multiple variants or genotypes. Our ongoing surveillance suggests that the H7N9 virus has become enzootic in chickens, and disseminated to most regions of China during waves III and IV of the outbreak. In this study, we have generated more than 800 H7N9 virus full genome sequences, and are analyzing these together with all genomes available in public databases. We are exploring the following scientific questions: (i) what is the continuing evolutionary behavior of the H7N9 virus lineage; (ii) what are the interactions or gene transfers between circulating H7N9 viruses and other enzootic influenza viruses, and the changes in genotypes over the four waves; (iii) what are the interactions among sub-lineages or clades, i.e. predominance and/or sub-lineage replacement; and (iv) what is the development and dissemination of the H7N9 viruses from a phylogeographic perspective. We hope that the information generated by this project will provide insights into methods to manage the development of the H7N9 outbreak and help to avert similar situations from arising.
Persistent Identifierhttp://hdl.handle.net/10722/247080
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLi, L-
dc.contributor.authorHong, W-
dc.contributor.authorDuan, L-
dc.contributor.authorWang, J-
dc.contributor.authorLam, TY-
dc.contributor.authorZhu, H-
dc.contributor.authorGuan, Y-
dc.date.accessioned2017-10-18T08:21:55Z-
dc.date.available2017-10-18T08:21:55Z-
dc.date.issued2017-
dc.identifier.citation21st International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology (VEME), Seoul, Korea, 14-19 August 2016. In Virus Evolution, 2017, v. 3 n. Suppl 1, p. pii: vew036.006-
dc.identifier.issn2057-1577-
dc.identifier.urihttp://hdl.handle.net/10722/247080-
dc.description.abstractThe H7N9 influenza virus that emerged in East China in early 2013 has caused 736 human infections with a fatality rate of 38.5%, through four outbreak waves. Our previous studies revealed that this virus was generated by reassortment between viruses from wild bird H7 and N9 viruses (surface genes) and poultry H9N2 viruses (internal genes), and that while the H7N9 wave I viruses had highly similar surface genes, the surface genes of the wave II viruses developed into regionally distinct clades. The H7N9 viruses continued to reassort with different H9N2 viruses to obtain internal gene segments, thereby generating multiple variants or genotypes. Our ongoing surveillance suggests that the H7N9 virus has become enzootic in chickens, and disseminated to most regions of China during waves III and IV of the outbreak. In this study, we have generated more than 800 H7N9 virus full genome sequences, and are analyzing these together with all genomes available in public databases. We are exploring the following scientific questions: (i) what is the continuing evolutionary behavior of the H7N9 virus lineage; (ii) what are the interactions or gene transfers between circulating H7N9 viruses and other enzootic influenza viruses, and the changes in genotypes over the four waves; (iii) what are the interactions among sub-lineages or clades, i.e. predominance and/or sub-lineage replacement; and (iv) what is the development and dissemination of the H7N9 viruses from a phylogeographic perspective. We hope that the information generated by this project will provide insights into methods to manage the development of the H7N9 outbreak and help to avert similar situations from arising.-
dc.languageeng-
dc.publisherOxford University Press.-
dc.relation.ispartofVirus Evolution-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleEvolution of influenza A(H7N9) viruses from waves I to IV-
dc.typeConference_Paper-
dc.identifier.emailLi, L: lifeng@hkucc.hku.hk-
dc.identifier.emailLam, TY: ttylam@hku.hk-
dc.identifier.emailZhu, H: zhuhch@hku.hk-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hk-
dc.identifier.authorityLam, TY=rp01733-
dc.identifier.authorityZhu, H=rp01535-
dc.identifier.authorityGuan, Y=rp00397-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/ve/vew036.006-
dc.identifier.pmid28845281-
dc.identifier.pmcidPMC5565997-
dc.identifier.hkuros280541-
dc.identifier.volume3-
dc.identifier.issueSuppl 1-
dc.identifier.spagepii: vew036.006.-
dc.identifier.epagepii: vew036.006.-
dc.publisher.placeOxford, UK-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats