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Conference Paper: Arresting early-childhood-caries with silver nitrate and sodium fluoride – 12-month result
Title | Arresting early-childhood-caries with silver nitrate and sodium fluoride – 12-month result |
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Authors | |
Issue Date | 2017 |
Publisher | International Association for Dental Research. |
Citation | The 31st IADR-SEA & 28th SEAADE Annual Scientific Meeting & 40th CTADS Annual Scientific Meeting, Taipei, Taiwan, 10-13 August 2017, p. S0001 How to Cite? |
Abstract | Objectives: To compare the effectiveness of an adjunctive application of 25% silver nitrate (AgNO3) solution followed by 5% sodium fluoride (NaF) varnish with 38% silver diamine fluoride (SDF) solution in arresting early-childhood-caries (ECC).
Methods: This is a randomised, double-blinded, non-inferiority clinical trial registered in ClinicalTrial.gov (NCT02019160). The hypothesis is that adjunctive application of 25% AgNO3 followed by 5% NaF is not appreciably worse than 38% SDF in arresting ECC. Healthy 3-year-old kindergarten children with active caries were randomly allocated into 2 groups for intervention: Group A – application of 25% AgNO3 solution followed by 5% NaF varnish every 6 months, and Group B – application of 38% SDF solution followed by placebo varnish every 6 months. Decayed, missing, filled surfaces (dmfs) and status of the carious surfaces (active or arrested) were recorded at baseline and after 6 and 12 months. The outcome measure is the number of active carious surfaces that become arrested. Intention-to-treat analysis was performed. Non-inferiority of Group A was accepted if the lower limit of the confidence interval (CI) for the difference in mean arrested carious surfaces was greater than -0.5.
Results: A total of 1,070 children with untreated caries were recruited with 535 children in each group. After 12 months, the dmfs in Group A and B were 7.32±6.99 and 7.43±6.87, respectively (p=0.947) and the mean of arrested decayed surfaces in Group A and B were 3.02±3.41 and 3.01±3.46, respectively (p=0.972). The estimate mean difference of arrested surfaces between two groups was 0.007 (95% CI: -0.404 to 0.419). The lower limit of 95% CI was greater than -0.5, indicating that Group A had a non-inferiority effect as Group B for caries arrest.
Conclusions: Application of 25% AgNO3 solution followed by 5% NaF varnish had a non-inferiority effect as 38% SDF in arresting ECC in young children after 12 months. |
Persistent Identifier | http://hdl.handle.net/10722/247709 |
DC Field | Value | Language |
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dc.contributor.author | Gao, SS | - |
dc.contributor.author | Lo, ECM | - |
dc.contributor.author | Chu, CH | - |
dc.date.accessioned | 2017-10-18T08:31:23Z | - |
dc.date.available | 2017-10-18T08:31:23Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | The 31st IADR-SEA & 28th SEAADE Annual Scientific Meeting & 40th CTADS Annual Scientific Meeting, Taipei, Taiwan, 10-13 August 2017, p. S0001 | - |
dc.identifier.uri | http://hdl.handle.net/10722/247709 | - |
dc.description.abstract | Objectives: To compare the effectiveness of an adjunctive application of 25% silver nitrate (AgNO3) solution followed by 5% sodium fluoride (NaF) varnish with 38% silver diamine fluoride (SDF) solution in arresting early-childhood-caries (ECC). Methods: This is a randomised, double-blinded, non-inferiority clinical trial registered in ClinicalTrial.gov (NCT02019160). The hypothesis is that adjunctive application of 25% AgNO3 followed by 5% NaF is not appreciably worse than 38% SDF in arresting ECC. Healthy 3-year-old kindergarten children with active caries were randomly allocated into 2 groups for intervention: Group A – application of 25% AgNO3 solution followed by 5% NaF varnish every 6 months, and Group B – application of 38% SDF solution followed by placebo varnish every 6 months. Decayed, missing, filled surfaces (dmfs) and status of the carious surfaces (active or arrested) were recorded at baseline and after 6 and 12 months. The outcome measure is the number of active carious surfaces that become arrested. Intention-to-treat analysis was performed. Non-inferiority of Group A was accepted if the lower limit of the confidence interval (CI) for the difference in mean arrested carious surfaces was greater than -0.5. Results: A total of 1,070 children with untreated caries were recruited with 535 children in each group. After 12 months, the dmfs in Group A and B were 7.32±6.99 and 7.43±6.87, respectively (p=0.947) and the mean of arrested decayed surfaces in Group A and B were 3.02±3.41 and 3.01±3.46, respectively (p=0.972). The estimate mean difference of arrested surfaces between two groups was 0.007 (95% CI: -0.404 to 0.419). The lower limit of 95% CI was greater than -0.5, indicating that Group A had a non-inferiority effect as Group B for caries arrest. Conclusions: Application of 25% AgNO3 solution followed by 5% NaF varnish had a non-inferiority effect as 38% SDF in arresting ECC in young children after 12 months. | - |
dc.language | eng | - |
dc.publisher | International Association for Dental Research. | - |
dc.relation.ispartof | International Association for Dental Research South East Asian Division Meeting (IADR-SEA) | - |
dc.title | Arresting early-childhood-caries with silver nitrate and sodium fluoride – 12-month result | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lo, ECM: edward-lo@hku.hk | - |
dc.identifier.email | Chu, CH: chchu@hku.hk | - |
dc.identifier.authority | Lo, ECM=rp00015 | - |
dc.identifier.authority | Chu, CH=rp00022 | - |
dc.identifier.hkuros | 280892 | - |
dc.identifier.spage | S0001 | - |
dc.identifier.epage | S0001 | - |
dc.publisher.place | Taipei, Taiwan | - |