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Article: Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

TitleHeterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized
Authors
Jiang, ZhiwuDeng, ManmanWei, XinruYe, WeiXiao, YirenLin, SimiaoWang, SunaLi, BaihengLiu, XinZhang, GongLai, PeilongWeng, JianyuWu, DonghaiChen, HaijiaWei, WeiMa, YuguoLi, YangqiuLiu, PentaoDu, XinPei, DuanqingYao, YaoXu, BingLi, Peng
KeywordsXenografts
B-ALL
Heterogeneity
Leukemia stem cell
Issue Date2016
Citation
Journal of Hematology and Oncology, 2016, v. 9, n. 1, p. 1-5 How to Cite?
DOI: http://dx.doi.org/10.1186/s13045-016-0310-1
Abstract© 2016 The Author(s). The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized.
Persistent Identifierhttp://hdl.handle.net/10722/249132
ISI Accession Number ID
WOS:000383951000002

 

DC FieldValueLanguage
dc.contributor.authorJiang, Zhiwu-
dc.contributor.authorDeng, Manman-
dc.contributor.authorWei, Xinru-
dc.contributor.authorYe, Wei-
dc.contributor.authorXiao, Yiren-
dc.contributor.authorLin, Simiao-
dc.contributor.authorWang, Suna-
dc.contributor.authorLi, Baiheng-
dc.contributor.authorLiu, Xin-
dc.contributor.authorZhang, Gong-
dc.contributor.authorLai, Peilong-
dc.contributor.authorWeng, Jianyu-
dc.contributor.authorWu, Donghai-
dc.contributor.authorChen, Haijia-
dc.contributor.authorWei, Wei-
dc.contributor.authorMa, Yuguo-
dc.contributor.authorLi, Yangqiu-
dc.contributor.authorLiu, Pentao-
dc.contributor.authorDu, Xin-
dc.contributor.authorPei, Duanqing-
dc.contributor.authorYao, Yao-
dc.contributor.authorXu, Bing-
dc.contributor.authorLi, Peng-
dc.date.accessioned2017-10-27T05:59:11Z-
dc.date.available2017-10-27T05:59:11Z-
dc.date.issued2016-
dc.identifier.citationJournal of Hematology and Oncology, 2016, v. 9, n. 1, p. 1-5-
dc.identifier.urihttp://hdl.handle.net/10722/249132-
dc.description.abstract© 2016 The Author(s). The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized.-
dc.languageeng-
dc.relation.ispartofJournal of Hematology and Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectXenografts-
dc.subjectB-ALL-
dc.subjectHeterogeneity-
dc.subjectLeukemia stem cell-
dc.titleHeterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13045-016-0310-1-
dc.identifier.scopuseid_2-s2.0-84994853761-
dc.identifier.volume9-
dc.identifier.issue1-
dc.identifier.spage1-
dc.identifier.epage5-
dc.identifier.eissn1756-8722-
dc.identifier.isiWOS:000383951000002-
dc.identifier.issnl1756-8722-

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