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- Publisher Website: 10.1016/j.ultrasmedbio.2017.05.017
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Article: Left atrial mechanics and integrated calibrated backscatter in anthracycline-treated long-term survivors of childhood cancers
Title | Left atrial mechanics and integrated calibrated backscatter in anthracycline-treated long-term survivors of childhood cancers |
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Authors | |
Keywords | Calibrated integrated backscatter Childhood cancer survivors Left atrial mechanics Ultrasound |
Issue Date | 2017 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ultrasmedbio |
Citation | Ultrasound in Medicine and Biology, 2017, v. 43 n. 9, p. 1897-1905 How to Cite? |
Abstract | We tested the hypothesis that left atrial (LA) mechanics and myocardial calibrated integrated backscatter (cIB) are altered in anthracycline-treated long-term survivors of childhood cancers. Forty-nine survivors and 25 controls were studied. Survivors had significantly smaller maximal (p = 0.009) and minimal (p = 0.017) LA volumes and lower peak negative LA strains (p = 0.011). For left ventricular (LV) indices, survivors had significantly lower shortening fraction (p < 0.001), ejection fraction (p < 0.001) and mitral annular late diastolic velocity (p = 0.003). Myocardial cIB of the LA posterior wall, ventricular septum and LV posterior wall was significantly greater in survivors than controls (all p values <0.05). Peak negative LA strain was related to late diastolic mitral annular velocity (r = 0.27, p = 0.018), whereas LA cIB was related to the average of septal and LV posterior wall cIB (r = 0.54, p < 0.001). In conclusion, LA remodeling as characterized by contractile dysfunction and increased cIB suggestive of fibrosis occurs in adult survivors of childhood cancers. © 2017 World Federation for Ultrasound in Medicine & Biology |
Persistent Identifier | http://hdl.handle.net/10722/249295 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.716 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LI, WYV | - |
dc.contributor.author | Lai, CTM | - |
dc.contributor.author | Liu, APY | - |
dc.contributor.author | Cheuk, KLD | - |
dc.contributor.author | Cheung, YF | - |
dc.date.accessioned | 2017-11-21T03:00:11Z | - |
dc.date.available | 2017-11-21T03:00:11Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Ultrasound in Medicine and Biology, 2017, v. 43 n. 9, p. 1897-1905 | - |
dc.identifier.issn | 0301-5629 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249295 | - |
dc.description.abstract | We tested the hypothesis that left atrial (LA) mechanics and myocardial calibrated integrated backscatter (cIB) are altered in anthracycline-treated long-term survivors of childhood cancers. Forty-nine survivors and 25 controls were studied. Survivors had significantly smaller maximal (p = 0.009) and minimal (p = 0.017) LA volumes and lower peak negative LA strains (p = 0.011). For left ventricular (LV) indices, survivors had significantly lower shortening fraction (p < 0.001), ejection fraction (p < 0.001) and mitral annular late diastolic velocity (p = 0.003). Myocardial cIB of the LA posterior wall, ventricular septum and LV posterior wall was significantly greater in survivors than controls (all p values <0.05). Peak negative LA strain was related to late diastolic mitral annular velocity (r = 0.27, p = 0.018), whereas LA cIB was related to the average of septal and LV posterior wall cIB (r = 0.54, p < 0.001). In conclusion, LA remodeling as characterized by contractile dysfunction and increased cIB suggestive of fibrosis occurs in adult survivors of childhood cancers. © 2017 World Federation for Ultrasound in Medicine & Biology | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ultrasmedbio | - |
dc.relation.ispartof | Ultrasound in Medicine and Biology | - |
dc.rights | Posting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Calibrated integrated backscatter | - |
dc.subject | Childhood cancer survivors | - |
dc.subject | Left atrial mechanics | - |
dc.subject | Ultrasound | - |
dc.title | Left atrial mechanics and integrated calibrated backscatter in anthracycline-treated long-term survivors of childhood cancers | - |
dc.type | Article | - |
dc.identifier.email | Liu, APY: apyliu@hku.hk | - |
dc.identifier.email | Cheuk, KLD: klcheuk@hkucc.hku.hk | - |
dc.identifier.email | Cheung, YF: xfcheung@hku.hk | - |
dc.identifier.authority | Liu, APY=rp01357 | - |
dc.identifier.authority | Cheung, YF=rp00382 | - |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2017.05.017 | - |
dc.identifier.scopus | eid_2-s2.0-85020866276 | - |
dc.identifier.hkuros | 283155 | - |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1897 | - |
dc.identifier.epage | 1905 | - |
dc.identifier.isi | WOS:000406420200017 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0301-5629 | - |