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- Publisher Website: 10.1111/dme.13601
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Article: Hypertriglyceridaemic-waist phenotype and risk of diabetes in people with impaired fasting glucose in primary care: a cohort study
Title | Hypertriglyceridaemic-waist phenotype and risk of diabetes in people with impaired fasting glucose in primary care: a cohort study |
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Authors | |
Issue Date | 2018 |
Citation | Diabetic Medicine, 2018, v. 35 n. 5, p. 576-582 How to Cite? |
Abstract | Aim: We aimed to determine the prospective association between baseline triglyceridaemic–waist phenotypes and diabetic mellitus incidence in individuals with impaired fasting glucose seen in primary care. Methods: A cohort of 1101 participants (84.4% of the recruited individuals) with impaired fasting glucose were recruited from three primary care clinics during regular follow-ups to monitor their chronic conditions. Baseline triglyceridaemic–waist phenotypes were divided into four groups: (1) normal waistline and triglyceride level (n = 252); (2) isolated central obesity (n = 518); (3) isolated high triglyceride level (n = 80); and (4) central obesity with high triglyceride level (i.e. hypertriglyceridaemic–waist phenotype) (n = 251). The presence of diabetes at follow-up was determined by fasting plasma glucose (≥ 7.0 mmol/l) and/or 2-h 75-g oral glucose tolerance test (≥ 11.1 mmol/l) and/or HbA1c (47.5 mmol/mol; ≥ 6.5%) according to American Diabetes Association diagnostic criteria. Multivariable Cox proportional hazards regressions were established to assess the impact of different triglyceridaemic–waist phenotypes on time to diabetes onset. Results: After a mean follow-up period of 6.5 months (sd 4.7 months), the number of diabetes cases was significantly higher in the group with hypertriglyceridaemic–waist phenotype (52.2%) compared with the other three phenotype groups (group 1: 28.2%; group 2: 34.6%; group 3: 30.0%). Only the hypertriglyceridaemic–waist phenotype showed an increased risk of developing diabetes (hazard ratio 1.581, 95% CI 1.172–2.134; P = 0.003) compared with the group with normal waistline and triglyceride level after controlling for confounders. Conclusion: The combination of central obesity and hypertriglyceridaemia is associated with > 50% risk of progression to diabetes within 6 months among individuals with impaired fasting glucose seen in primary care. |
Persistent Identifier | http://hdl.handle.net/10722/251441 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Guo, Y | - |
dc.contributor.author | Yu, YTE | - |
dc.contributor.author | Wong, CKH | - |
dc.contributor.author | Sit, RWS | - |
dc.contributor.author | Wang, JHL | - |
dc.contributor.author | Lam, CLK | - |
dc.date.accessioned | 2018-03-01T03:39:21Z | - |
dc.date.available | 2018-03-01T03:39:21Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Diabetic Medicine, 2018, v. 35 n. 5, p. 576-582 | - |
dc.identifier.uri | http://hdl.handle.net/10722/251441 | - |
dc.description.abstract | Aim: We aimed to determine the prospective association between baseline triglyceridaemic–waist phenotypes and diabetic mellitus incidence in individuals with impaired fasting glucose seen in primary care. Methods: A cohort of 1101 participants (84.4% of the recruited individuals) with impaired fasting glucose were recruited from three primary care clinics during regular follow-ups to monitor their chronic conditions. Baseline triglyceridaemic–waist phenotypes were divided into four groups: (1) normal waistline and triglyceride level (n = 252); (2) isolated central obesity (n = 518); (3) isolated high triglyceride level (n = 80); and (4) central obesity with high triglyceride level (i.e. hypertriglyceridaemic–waist phenotype) (n = 251). The presence of diabetes at follow-up was determined by fasting plasma glucose (≥ 7.0 mmol/l) and/or 2-h 75-g oral glucose tolerance test (≥ 11.1 mmol/l) and/or HbA1c (47.5 mmol/mol; ≥ 6.5%) according to American Diabetes Association diagnostic criteria. Multivariable Cox proportional hazards regressions were established to assess the impact of different triglyceridaemic–waist phenotypes on time to diabetes onset. Results: After a mean follow-up period of 6.5 months (sd 4.7 months), the number of diabetes cases was significantly higher in the group with hypertriglyceridaemic–waist phenotype (52.2%) compared with the other three phenotype groups (group 1: 28.2%; group 2: 34.6%; group 3: 30.0%). Only the hypertriglyceridaemic–waist phenotype showed an increased risk of developing diabetes (hazard ratio 1.581, 95% CI 1.172–2.134; P = 0.003) compared with the group with normal waistline and triglyceride level after controlling for confounders. Conclusion: The combination of central obesity and hypertriglyceridaemia is associated with > 50% risk of progression to diabetes within 6 months among individuals with impaired fasting glucose seen in primary care. | - |
dc.language | eng | - |
dc.relation.ispartof | Diabetic Medicine | - |
dc.rights | Postprint This is the peer reviewed version of the following article: [Diabetic Medicine, 2018, v. 35 n. 5, p. 576-582], which has been published in final form at [http://dx.doi.org/10.1111/dme.13601]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.title | Hypertriglyceridaemic-waist phenotype and risk of diabetes in people with impaired fasting glucose in primary care: a cohort study | - |
dc.type | Article | - |
dc.identifier.email | Guo, Y: viviguo@hku.hk | - |
dc.identifier.email | Yu, YTE: ytyu@hku.hk | - |
dc.identifier.email | Wong, CKH: carlosho@hku.hk | - |
dc.identifier.email | Lam, CLK: clklam@hku.hk | - |
dc.identifier.authority | Yu, YTE=rp01693 | - |
dc.identifier.authority | Wong, CKH=rp01931 | - |
dc.identifier.authority | Lam, CLK=rp00350 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1111/dme.13601 | - |
dc.identifier.scopus | eid_2-s2.0-85043343789 | - |
dc.identifier.hkuros | 284358 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 576 | - |
dc.identifier.epage | 582 | - |
dc.identifier.isi | WOS:000430118900006 | - |