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Article: MicroRNA-mediated immune regulation in rheumatic diseases

TitleMicroRNA-mediated immune regulation in rheumatic diseases
Authors
Issue Date2018
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2018, v. 431, p. 201-212 How to Cite?
AbstractMicroRNAs (miRNAs) are endogenous small, non-coding RNAs that regulate genome expression at the posttranscriptional level. They are involved in a wide range of physiological processes including the maintenance of immune homeostasis and normal function. Accumulating evidence from animal studies show that alterations in pan or specific miRNA expression would break immunological tolerance, leading to autoimmunity. Differential miRNA expressions have also been documented in patients of many autoimmune disorders. In this review, we highlight the evidence that signifies the critical role of miRNAs in autoimmunity, specifically on their regulatory roles in the pathogenesis of several rheumatic diseases including systemic lupus erythematosus, rheumatoid arthritis and spondyloarthritis. The potential of miRNAs as biomarkers and therapeutic targets is also discussed. Manipulation of dysregulated miRNAs in vivo through miRNA delivery or inhibition offers promise for new therapeutic strategies in treating rheumatic diseases.
Persistent Identifierhttp://hdl.handle.net/10722/254729
ISSN
2019 Impact Factor: 7.36
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KYI-
dc.contributor.authorChow, JX-
dc.contributor.authorLau, WCS-
dc.contributor.authorChan, VSF-
dc.date.accessioned2018-06-21T01:05:35Z-
dc.date.available2018-06-21T01:05:35Z-
dc.date.issued2018-
dc.identifier.citationCancer Letters, 2018, v. 431, p. 201-212-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10722/254729-
dc.description.abstractMicroRNAs (miRNAs) are endogenous small, non-coding RNAs that regulate genome expression at the posttranscriptional level. They are involved in a wide range of physiological processes including the maintenance of immune homeostasis and normal function. Accumulating evidence from animal studies show that alterations in pan or specific miRNA expression would break immunological tolerance, leading to autoimmunity. Differential miRNA expressions have also been documented in patients of many autoimmune disorders. In this review, we highlight the evidence that signifies the critical role of miRNAs in autoimmunity, specifically on their regulatory roles in the pathogenesis of several rheumatic diseases including systemic lupus erythematosus, rheumatoid arthritis and spondyloarthritis. The potential of miRNAs as biomarkers and therapeutic targets is also discussed. Manipulation of dysregulated miRNAs in vivo through miRNA delivery or inhibition offers promise for new therapeutic strategies in treating rheumatic diseases.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet-
dc.relation.ispartofCancer Letters-
dc.titleMicroRNA-mediated immune regulation in rheumatic diseases-
dc.typeArticle-
dc.identifier.emailLau, WCS: cslau@hku.hk-
dc.identifier.emailChan, VSF: sfvchan@hku.hk-
dc.identifier.authorityLau, WCS=rp01348-
dc.identifier.authorityChan, VSF=rp01459-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2018.05.044-
dc.identifier.scopuseid_2-s2.0-85048577966-
dc.identifier.hkuros285602-
dc.identifier.hkuros288314-
dc.identifier.volume431-
dc.identifier.spage201-
dc.identifier.epage212-
dc.identifier.isiWOS:000438477500020-
dc.publisher.placeIreland-

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