File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.canlet.2018.05.044
- Scopus: eid_2-s2.0-85048577966
- WOS: WOS:000438477500020
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: MicroRNA-mediated immune regulation in rheumatic diseases
Title | MicroRNA-mediated immune regulation in rheumatic diseases |
---|---|
Authors | |
Keywords | Autoimmunity Lupus Rheumatism Rheumatoid arthritis Small non-coding RNAs |
Issue Date | 2018 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet |
Citation | Cancer Letters, 2018, v. 431, p. 201-212 How to Cite? |
Abstract | MicroRNAs (miRNAs) are endogenous small, non-coding RNAs that regulate genome expression at the posttranscriptional level. They are involved in a wide range of physiological processes including the maintenance of immune homeostasis and normal function. Accumulating evidence from animal studies show that alterations in pan or specific miRNA expression would break immunological tolerance, leading to autoimmunity. Differential miRNA expressions have also been documented in patients of many autoimmune disorders. In this review, we highlight the evidence that signifies the critical role of miRNAs in autoimmunity, specifically on their regulatory roles in the pathogenesis of several rheumatic diseases including systemic lupus erythematosus, rheumatoid arthritis and spondyloarthritis. The potential of miRNAs as biomarkers and therapeutic targets is also discussed. Manipulation of dysregulated miRNAs in vivo through miRNA delivery or inhibition offers promise for new therapeutic strategies in treating rheumatic diseases. |
Persistent Identifier | http://hdl.handle.net/10722/254729 |
ISSN | 2021 Impact Factor: 9.756 2020 SCImago Journal Rankings: 2.470 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, KYI | - |
dc.contributor.author | Chow, JX | - |
dc.contributor.author | Lau, WCS | - |
dc.contributor.author | Chan, VSF | - |
dc.date.accessioned | 2018-06-21T01:05:35Z | - |
dc.date.available | 2018-06-21T01:05:35Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Cancer Letters, 2018, v. 431, p. 201-212 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10722/254729 | - |
dc.description.abstract | MicroRNAs (miRNAs) are endogenous small, non-coding RNAs that regulate genome expression at the posttranscriptional level. They are involved in a wide range of physiological processes including the maintenance of immune homeostasis and normal function. Accumulating evidence from animal studies show that alterations in pan or specific miRNA expression would break immunological tolerance, leading to autoimmunity. Differential miRNA expressions have also been documented in patients of many autoimmune disorders. In this review, we highlight the evidence that signifies the critical role of miRNAs in autoimmunity, specifically on their regulatory roles in the pathogenesis of several rheumatic diseases including systemic lupus erythematosus, rheumatoid arthritis and spondyloarthritis. The potential of miRNAs as biomarkers and therapeutic targets is also discussed. Manipulation of dysregulated miRNAs in vivo through miRNA delivery or inhibition offers promise for new therapeutic strategies in treating rheumatic diseases. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet | - |
dc.relation.ispartof | Cancer Letters | - |
dc.subject | Autoimmunity | - |
dc.subject | Lupus | - |
dc.subject | Rheumatism | - |
dc.subject | Rheumatoid arthritis | - |
dc.subject | Small non-coding RNAs | - |
dc.title | MicroRNA-mediated immune regulation in rheumatic diseases | - |
dc.type | Article | - |
dc.identifier.email | Lau, WCS: cslau@hku.hk | - |
dc.identifier.email | Chan, VSF: sfvchan@hku.hk | - |
dc.identifier.authority | Lau, WCS=rp01348 | - |
dc.identifier.authority | Chan, VSF=rp01459 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.canlet.2018.05.044 | - |
dc.identifier.scopus | eid_2-s2.0-85048577966 | - |
dc.identifier.hkuros | 285602 | - |
dc.identifier.hkuros | 288314 | - |
dc.identifier.volume | 431 | - |
dc.identifier.spage | 201 | - |
dc.identifier.epage | 212 | - |
dc.identifier.isi | WOS:000438477500020 | - |
dc.publisher.place | Ireland | - |
dc.identifier.issnl | 0304-3835 | - |