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Article: Defining the sizes of airborne particles that mediate influenza transmission in ferrets

TitleDefining the sizes of airborne particles that mediate influenza transmission in ferrets
Authors
Zhou, JWei, JChoy, KTSia, SFRowlands, DKYu, DWu, CYLindsley, WGCowling, BJMcDevitt, JPeiris, JSMLi, YYen, H
KeywordsAirborne particles
Airborne transmission
Droplet transmission
Ferrets
Influenza virus
Issue Date2018
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings of the National Academy of Sciences, 2018, v. 115 n. 10, p. E2386-2392 How to Cite?
DOI: http://dx.doi.org/10.1073/pnas.1716771115
AbstractEpidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.
Persistent Identifierhttp://hdl.handle.net/10722/256165
ISSN
0027-8424
2021 Impact Factor: 12.779
2020 SCImago Journal Rankings: 5.011
PubMed Central ID
PMC5877994
ISI Accession Number ID
WOS:000426671900030

 

DC FieldValueLanguage
dc.contributor.authorZhou, J-
dc.contributor.authorWei, J-
dc.contributor.authorChoy, KT-
dc.contributor.authorSia, SF-
dc.contributor.authorRowlands, DK-
dc.contributor.authorYu, D-
dc.contributor.authorWu, CY-
dc.contributor.authorLindsley, WG-
dc.contributor.authorCowling, BJ-
dc.contributor.authorMcDevitt, J-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorLi, Y-
dc.contributor.authorYen, H-
dc.date.accessioned2018-07-20T06:30:10Z-
dc.date.available2018-07-20T06:30:10Z-
dc.date.issued2018-
dc.identifier.citationProceedings of the National Academy of Sciences, 2018, v. 115 n. 10, p. E2386-2392-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/256165-
dc.description.abstractEpidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.-
dc.languageeng-
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org-
dc.relation.ispartofProceedings of the National Academy of Sciences-
dc.rightsProceedings of the National Academy of Sciences. Copyright © National Academy of Sciences.-
dc.subjectAirborne particles-
dc.subjectAirborne transmission-
dc.subjectDroplet transmission-
dc.subjectFerrets-
dc.subjectInfluenza virus-
dc.titleDefining the sizes of airborne particles that mediate influenza transmission in ferrets-
dc.typeArticle-
dc.identifier.emailChoy, KT: ktchoy@hku.hk-
dc.identifier.emailSia, SF: sfsia@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailLi, Y: liyg@hku.hk-
dc.identifier.emailYen, H: hyen@hku.hk-
dc.identifier.authorityCowling, BJ=rp01326-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityLi, Y=rp00151-
dc.identifier.authorityYen, H=rp00304-
dc.identifier.doi10.1073/pnas.1716771115-
dc.identifier.pmcidPMC5877994-
dc.identifier.scopuseid_2-s2.0-85042942477-
dc.identifier.hkuros285851-
dc.identifier.volume115-
dc.identifier.issue10-
dc.identifier.spageE2386-
dc.identifier.epage2392-
dc.identifier.isiWOS:000426671900030-
dc.publisher.placeUnited States-
dc.identifier.issnl0027-8424-

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