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- Publisher Website: 10.3389/fimmu.2018.00516
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Article: Recognition of double-stranded RNA and regulation of interferon pathway by toll-like Receptor 10
Title | Recognition of double-stranded RNA and regulation of interferon pathway by toll-like Receptor 10 |
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Authors | |
Keywords | dsRNA IFN Interferon regulatory factor Ligand sequestration Myeloid differentiation primary response gene 88 Nucleotide-sensing receptor TLR10 Toll-like receptor |
Issue Date | 2018 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology |
Citation | Frontiers in Immunology, 2018, v. 9, p. 516:1-516:15 How to Cite? |
Abstract | Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid differentiation primary response gene 88 for signal transduction and suppression of interferon regulatory factor-7 dependent type I IFN production. We also demonstrate crosstalk between TLR10 and TLR3, as they compete with each other for dsRNA binding. Our results suggest for the first time that dsRNA is a ligand for TLR10 and propose novel dual functions of TLR10 in regulating IFN signaling: first, recognition of dsRNA as a nucleotide-sensing receptor and second, sequestration of dsRNA from TLR3 to inhibit TLR3 signaling in response to dsRNA stimulation. |
Persistent Identifier | http://hdl.handle.net/10722/258333 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.868 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lee, MY | - |
dc.contributor.author | Yip, TF | - |
dc.contributor.author | Yan, S | - |
dc.contributor.author | Jin, D | - |
dc.contributor.author | Wei, HL | - |
dc.contributor.author | Guo, RT | - |
dc.contributor.author | Peiris, JSM | - |
dc.date.accessioned | 2018-08-22T01:36:48Z | - |
dc.date.available | 2018-08-22T01:36:48Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Frontiers in Immunology, 2018, v. 9, p. 516:1-516:15 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/10722/258333 | - |
dc.description.abstract | Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid differentiation primary response gene 88 for signal transduction and suppression of interferon regulatory factor-7 dependent type I IFN production. We also demonstrate crosstalk between TLR10 and TLR3, as they compete with each other for dsRNA binding. Our results suggest for the first time that dsRNA is a ligand for TLR10 and propose novel dual functions of TLR10 in regulating IFN signaling: first, recognition of dsRNA as a nucleotide-sensing receptor and second, sequestration of dsRNA from TLR3 to inhibit TLR3 signaling in response to dsRNA stimulation. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology | - |
dc.relation.ispartof | Frontiers in Immunology | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | dsRNA | - |
dc.subject | IFN | - |
dc.subject | Interferon regulatory factor | - |
dc.subject | Ligand sequestration | - |
dc.subject | Myeloid differentiation primary response gene 88 | - |
dc.subject | Nucleotide-sensing receptor | - |
dc.subject | TLR10 | - |
dc.subject | Toll-like receptor | - |
dc.title | Recognition of double-stranded RNA and regulation of interferon pathway by toll-like Receptor 10 | - |
dc.type | Article | - |
dc.identifier.email | Lee, MY: suki@hku.hk | - |
dc.identifier.email | Yip, TF: yiptf@hku.hk | - |
dc.identifier.email | Yan, S: ssyan@hku.hk | - |
dc.identifier.email | Jin, D: dyjin@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.authority | Lee, MY=rp01536 | - |
dc.identifier.authority | Jin, D=rp00452 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fimmu.2018.00516 | - |
dc.identifier.pmcid | PMC5865411 | - |
dc.identifier.scopus | eid_2-s2.0-85044118717 | - |
dc.identifier.hkuros | 286571 | - |
dc.identifier.volume | 9 | - |
dc.identifier.spage | 516:1 | - |
dc.identifier.epage | 516:15 | - |
dc.identifier.isi | WOS:000427607200001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1664-3224 | - |