File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: EBV-associated Histone Modifications in the Regulation of DNA Damage Repair Members in Nasopharyngeal Carcinoma.

TitleEBV-associated Histone Modifications in the Regulation of DNA Damage Repair Members in Nasopharyngeal Carcinoma.
Authors
KeywordsEBV
Histone modification
NPC
Issue Date2017
PublisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS
Citation
The 76th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan, 28-30 September 2017. Abstracts in Cancer Science, 2017, v. 109 n. Suppl. 1, p. 184 How to Cite?
AbstractInfection of an oncovirus, Epstein - Barr virus (EBV), is associated with certain cancers including nasopharygeal carcinoma (NPC). However, the possible roles of EBV in NPC development are still poorly understood. In this study, we aimed to elucidate the roles of EBV in the regulation of DNA damage repair members via histone modifications H3K4me3. Two pairs of EBV-positive and EBV-negative nasopharygeal epithelial (NPE) cell lines were used for chromatin immunoprecipitation sequencing (ChIP-Seq) to identify EBV-regulated genes in the host cells. Totally, 18 DNA damage repair signalling members showed significant losses of H3K4me3 in EBV-infected NPE cells. Among all the candidate genes, 7 base excision repair (BER) members, APEX, POLB , POLD1 , PCNA, TDG, OGG1, and NEIL3 , and a mismatch repair (MMR) member, MLH1 , showed significant downregulation in the EBV-infected cells. The clinical significance was further confirmed by detection of significant down-regulation of the BER members and MLH1 in NPC paired biopsies. Our results suggested EBV infection induces loss of H3K4me3 in the BER members and MLH1 , resulting in downregulation in the EBV-infected cells and NPC tumor biopsies.
DescriptionPoster Sessions (P3-2): EBV - no. P-1037
Persistent Identifierhttp://hdl.handle.net/10722/258496
ISSN
2019 Impact Factor: 4.966
2015 SCImago Journal Rankings: 1.744

 

DC FieldValueLanguage
dc.contributor.authorLeong, ML-
dc.contributor.authorCheung, AKL-
dc.contributor.authorDai, W-
dc.contributor.authorTsao, GSW-
dc.contributor.authorLung, ML-
dc.date.accessioned2018-08-22T01:39:27Z-
dc.date.available2018-08-22T01:39:27Z-
dc.date.issued2017-
dc.identifier.citationThe 76th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan, 28-30 September 2017. Abstracts in Cancer Science, 2017, v. 109 n. Suppl. 1, p. 184-
dc.identifier.issn1347-9032-
dc.identifier.urihttp://hdl.handle.net/10722/258496-
dc.descriptionPoster Sessions (P3-2): EBV - no. P-1037-
dc.description.abstractInfection of an oncovirus, Epstein - Barr virus (EBV), is associated with certain cancers including nasopharygeal carcinoma (NPC). However, the possible roles of EBV in NPC development are still poorly understood. In this study, we aimed to elucidate the roles of EBV in the regulation of DNA damage repair members via histone modifications H3K4me3. Two pairs of EBV-positive and EBV-negative nasopharygeal epithelial (NPE) cell lines were used for chromatin immunoprecipitation sequencing (ChIP-Seq) to identify EBV-regulated genes in the host cells. Totally, 18 DNA damage repair signalling members showed significant losses of H3K4me3 in EBV-infected NPE cells. Among all the candidate genes, 7 base excision repair (BER) members, APEX, POLB , POLD1 , PCNA, TDG, OGG1, and NEIL3 , and a mismatch repair (MMR) member, MLH1 , showed significant downregulation in the EBV-infected cells. The clinical significance was further confirmed by detection of significant down-regulation of the BER members and MLH1 in NPC paired biopsies. Our results suggested EBV infection induces loss of H3K4me3 in the BER members and MLH1 , resulting in downregulation in the EBV-infected cells and NPC tumor biopsies.-
dc.languageeng-
dc.publisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS-
dc.relation.ispartofCancer Science-
dc.relation.ispartofThe 76th Annual Meeting of the Japanese Cancer Association-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectEBV-
dc.subjectHistone modification-
dc.subjectNPC-
dc.titleEBV-associated Histone Modifications in the Regulation of DNA Damage Repair Members in Nasopharyngeal Carcinoma.-
dc.typeConference_Paper-
dc.identifier.emailCheung, AKL: arthurhk@hku.hk-
dc.identifier.emailDai, W: weidai2@hku.hk-
dc.identifier.emailTsao, GSW: gswtsao@hku.hk-
dc.identifier.emailLung, ML: mlilung@hku.hk-
dc.identifier.authorityCheung, AKL=rp01769-
dc.identifier.authorityDai, W=rp02146-
dc.identifier.authorityTsao, GSW=rp00399-
dc.identifier.authorityLung, ML=rp00300-
dc.identifier.hkuros286588-
dc.identifier.volume109-
dc.identifier.issueSuppl. 1-
dc.identifier.spage184-
dc.identifier.epage184-
dc.publisher.placeJapan-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats