File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging

TitleBaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging
Authors
KeywordsMetal-shell dielectric-core nanoparticles
Near-infrared absorption
Photothermal therapy
Second harmonic generation imaging
Two-photon luminescence imaging
Issue Date2018
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
Citation
Acta Biomaterialia, 2018, v. 72, p. 287-294 How to Cite?
AbstractWe report sub-100 nm metal-shell (Au) dielectric-core (BaTiO3) nanoparticles with bimodal imaging abilities and enhanced photothermal effects. The nanoparticles efficiently absorb light in the near infrared range of the spectrum and convert it to heat to ablate tumors. Their BaTiO3 core, a highly ordered non-centrosymmetric material, can be imaged by second harmonic generation, and their Au shell generates two-photon luminescence. The intrinsic dual imaging capability allows investigating the distribution of the nanoparticles in relation to the tumor vasculature morphology during photothermal ablation. Our design enabled in vivo real-time tracking of the BT-Au-NPs and observation of their thermally-induced effect on tumor vessels. STATEMENT OF SIGNIFICANCE: Photothermal therapy induced by plasmonic nanoparticles has emerged as a promising approach to treating cancer. However, the study of the role of intratumoral nanoparticle distribution in mediating tumoricidal activity has been hampered by the lack of suitable imaging techniques. This work describes metal-shell (Au) dielectric-core (BaTiO3) nanoparticles (abbreviated as BT-Au-NP) for photothermal therapy and bimodal imaging. We demonstrated that sub-100 nm BT-Au-NP can efficiently absorb near infrared light and convert it to heat to ablate tumors. The intrinsic dual imaging capability allowed us to investigate the distribution of the nanoparticles in relation to the tumor vasculature morphology during photothermal ablation, enabling in vivo real-time tracking of the BT-Au-NPs and observation of their thermally-induced effect on tumor vessels.
Persistent Identifierhttp://hdl.handle.net/10722/260278
ISSN
2017 Impact Factor: 6.383
2015 SCImago Journal Rankings: 2.020
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, YF-
dc.contributor.authorBarhoumi, A-
dc.contributor.authorTong, R-
dc.contributor.authorWang, W-
dc.contributor.authorJi, TJ-
dc.contributor.authorDeng, XR-
dc.contributor.authorLi, LL-
dc.contributor.authorLyon, SA-
dc.contributor.authorReznor, G-
dc.contributor.authorZurakowski, D-
dc.contributor.authorKohane, DS-
dc.date.accessioned2018-09-12T07:09:08Z-
dc.date.available2018-09-12T07:09:08Z-
dc.date.issued2018-
dc.identifier.citationActa Biomaterialia, 2018, v. 72, p. 287-294-
dc.identifier.issn1742-7061-
dc.identifier.urihttp://hdl.handle.net/10722/260278-
dc.description.abstractWe report sub-100 nm metal-shell (Au) dielectric-core (BaTiO3) nanoparticles with bimodal imaging abilities and enhanced photothermal effects. The nanoparticles efficiently absorb light in the near infrared range of the spectrum and convert it to heat to ablate tumors. Their BaTiO3 core, a highly ordered non-centrosymmetric material, can be imaged by second harmonic generation, and their Au shell generates two-photon luminescence. The intrinsic dual imaging capability allows investigating the distribution of the nanoparticles in relation to the tumor vasculature morphology during photothermal ablation. Our design enabled in vivo real-time tracking of the BT-Au-NPs and observation of their thermally-induced effect on tumor vessels. STATEMENT OF SIGNIFICANCE: Photothermal therapy induced by plasmonic nanoparticles has emerged as a promising approach to treating cancer. However, the study of the role of intratumoral nanoparticle distribution in mediating tumoricidal activity has been hampered by the lack of suitable imaging techniques. This work describes metal-shell (Au) dielectric-core (BaTiO3) nanoparticles (abbreviated as BT-Au-NP) for photothermal therapy and bimodal imaging. We demonstrated that sub-100 nm BT-Au-NP can efficiently absorb near infrared light and convert it to heat to ablate tumors. The intrinsic dual imaging capability allowed us to investigate the distribution of the nanoparticles in relation to the tumor vasculature morphology during photothermal ablation, enabling in vivo real-time tracking of the BT-Au-NPs and observation of their thermally-induced effect on tumor vessels.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat-
dc.relation.ispartofActa Biomaterialia-
dc.subjectMetal-shell dielectric-core nanoparticles-
dc.subjectNear-infrared absorption-
dc.subjectPhotothermal therapy-
dc.subjectSecond harmonic generation imaging-
dc.subjectTwo-photon luminescence imaging-
dc.titleBaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging-
dc.typeArticle-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, W=rp02227-
dc.identifier.doi10.1016/j.actbio.2018.03.029-
dc.identifier.pmid29578086-
dc.identifier.pmcidPMC5938150-
dc.identifier.volume72-
dc.identifier.spage287-
dc.identifier.epage294-
dc.identifier.isiWOS:000432766900024-
dc.publisher.placeNetherlands-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats