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Article: Prospective Study on Ex-PRESS Implantation Combined with Phacoemulsification in Primary Angle-closure Glaucoma Coexisting Cataract: 3-year Results

TitleProspective Study on Ex-PRESS Implantation Combined with Phacoemulsification in Primary Angle-closure Glaucoma Coexisting Cataract: 3-year Results
Authors
KeywordsAnterior chamber depth
Ex-PRESS
Filtering surgery
Glaucoma
Phacoemulsification
Issue Date2018
PublisherTaylor & Francis. The Journal's web site is located at http://www.tandfonline.com/icey
Citation
Current Eye Research, 2018, v. 43 n. 8, p. 1045-1051 How to Cite?
AbstractPurpose: To evaluate the feasibility, efficacy, and safety of Ex-PRESS implantation combined with phacoemulsification surgery in primary angle-closure glaucoma (PACG) with cataract. Materials and methods: This is a prospective, nonrandomized study. A total of 34 eyes of 34 subjects were enrolled. The assessments were conducted preoperatively and postoperatively at 1 week and 1, 3, 6, 12, 18, 24, 30, and 36 months. The assessments included intraocular pressure (IOP), best-corrected visual acuity (BCVA), the number of glaucoma medications, corneal endothelial cell density (ECD), and related complications, if any. The anterior segment structure was also assessed by anterior segment optical coherence tomography based on the anterior chamber depth (ACD), angle opening distance (AOD500), and trabecular-iris angle (TIA). A complete success was defined as a controlled IOP between 5 and 21 mmHg without medications. Results: The complete success rates at 12, 24, and 36 postoperative months were 91.2%, 81.7%, and 78.3%, respectively. The mean preoperative IOP was 28.43 ± 12.93 mmHg and decreased to 15.35 ± 4.02 mmHg at 3 years postoperatively (P < 0.001). The number of medications decreased from 2.47 ± 1.89 at baseline to 0.28 ± 0.76 at 3 years postoperatively (P = 0.001). BCVA was 0.83 ± 0.58 at baseline and 0.51 ± 0.33 at 3 years postoperatively (P = 0.008). The ACD, AOD500, and TIA significantly increased at 3 months postoperatively compared with baseline (P < 0.001). ECD at 3 months and 3 years postoperatively were both significantly lower compared with baseline (P = 0.03), but was not significantly different between 3 months and 3 years postoperatively (P = 0.07). The device-related complications identified were hypotony (5.8%), hyphema (2.9%), and iris touch (2.9%), which the incidence rates were all very low. Conclusions: Ex-PRESS implantation combined with phacoemulsification was effective for lowering IOP in PACG coexisting with cataract. The device-related complication was rare.
Persistent Identifierhttp://hdl.handle.net/10722/261791
ISSN
2017 Impact Factor: 2.12
2015 SCImago Journal Rankings: 0.975
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNie, L-
dc.contributor.authorFang, A-
dc.contributor.authorPan, W-
dc.contributor.authorYe, H-
dc.contributor.authorChan, YK-
dc.contributor.authorFu, L-
dc.contributor.authorQu, J-
dc.date.accessioned2018-09-28T04:47:56Z-
dc.date.available2018-09-28T04:47:56Z-
dc.date.issued2018-
dc.identifier.citationCurrent Eye Research, 2018, v. 43 n. 8, p. 1045-1051-
dc.identifier.issn0271-3683-
dc.identifier.urihttp://hdl.handle.net/10722/261791-
dc.description.abstractPurpose: To evaluate the feasibility, efficacy, and safety of Ex-PRESS implantation combined with phacoemulsification surgery in primary angle-closure glaucoma (PACG) with cataract. Materials and methods: This is a prospective, nonrandomized study. A total of 34 eyes of 34 subjects were enrolled. The assessments were conducted preoperatively and postoperatively at 1 week and 1, 3, 6, 12, 18, 24, 30, and 36 months. The assessments included intraocular pressure (IOP), best-corrected visual acuity (BCVA), the number of glaucoma medications, corneal endothelial cell density (ECD), and related complications, if any. The anterior segment structure was also assessed by anterior segment optical coherence tomography based on the anterior chamber depth (ACD), angle opening distance (AOD500), and trabecular-iris angle (TIA). A complete success was defined as a controlled IOP between 5 and 21 mmHg without medications. Results: The complete success rates at 12, 24, and 36 postoperative months were 91.2%, 81.7%, and 78.3%, respectively. The mean preoperative IOP was 28.43 ± 12.93 mmHg and decreased to 15.35 ± 4.02 mmHg at 3 years postoperatively (P < 0.001). The number of medications decreased from 2.47 ± 1.89 at baseline to 0.28 ± 0.76 at 3 years postoperatively (P = 0.001). BCVA was 0.83 ± 0.58 at baseline and 0.51 ± 0.33 at 3 years postoperatively (P = 0.008). The ACD, AOD500, and TIA significantly increased at 3 months postoperatively compared with baseline (P < 0.001). ECD at 3 months and 3 years postoperatively were both significantly lower compared with baseline (P = 0.03), but was not significantly different between 3 months and 3 years postoperatively (P = 0.07). The device-related complications identified were hypotony (5.8%), hyphema (2.9%), and iris touch (2.9%), which the incidence rates were all very low. Conclusions: Ex-PRESS implantation combined with phacoemulsification was effective for lowering IOP in PACG coexisting with cataract. The device-related complication was rare.-
dc.languageeng-
dc.publisherTaylor & Francis. The Journal's web site is located at http://www.tandfonline.com/icey-
dc.relation.ispartofCurrent Eye Research-
dc.subjectAnterior chamber depth-
dc.subjectEx-PRESS-
dc.subjectFiltering surgery-
dc.subjectGlaucoma-
dc.subjectPhacoemulsification-
dc.titleProspective Study on Ex-PRESS Implantation Combined with Phacoemulsification in Primary Angle-closure Glaucoma Coexisting Cataract: 3-year Results-
dc.typeArticle-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.authorityChan, YK=rp02536-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/02713683.2018.1464196-
dc.identifier.pmid29718724-
dc.identifier.scopuseid_2-s2.0-85046489754-
dc.identifier.hkuros293440-
dc.identifier.volume43-
dc.identifier.issue8-
dc.identifier.spage1045-
dc.identifier.epage1051-
dc.identifier.isiWOS:000439721700013-
dc.publisher.placeUnited Kingdom-

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