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Article: Deficiency in T follicular regulatory cells promotes autoimmunity

TitleDeficiency in T follicular regulatory cells promotes autoimmunity
Authors
Issue Date2018
PublisherRockefeller University Press. The Journal's web site is located at http://www.jem.org
Citation
The Journal of Experimental Medicine, 2018, v. 215, p. 815-825 How to Cite?
Abstract© 2018 Fu et al. T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6 fl/fl Foxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses. These mice exhibited enhanced immunity to influenza virus; moreover, Bcl6 fl/fl Foxp3Cre/Cre mice developed late-onset spontaneous autoimmune diseases, affecting the salivary glands with lymphocyte infiltration and antibody deposition. In a mouse experimental Sjögren's syndrome model, ablation of Bcl6 in T reg cells greatly enhanced disease development. Conversely, Bcl6 fl/fl Cd4Cre mice were protected in the model. Thus, our study indicates that Tfr cells control autoimmune diseases and can be targeted in infectious and autoimmune disease.
Persistent Identifierhttp://hdl.handle.net/10722/261929
ISSN
2017 Impact Factor: 10.79
2015 SCImago Journal Rankings: 10.762
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFu, W-
dc.contributor.authorLiu, X-
dc.contributor.authorLin, X-
dc.contributor.authorFeng, H-
dc.contributor.authorSun, L-
dc.contributor.authorLi, S-
dc.contributor.authorChen, H-
dc.contributor.authorTang, H-
dc.contributor.authorLu, L-
dc.contributor.authorJin, W-
dc.contributor.authorDong, C-
dc.date.accessioned2018-09-28T04:50:30Z-
dc.date.available2018-09-28T04:50:30Z-
dc.date.issued2018-
dc.identifier.citationThe Journal of Experimental Medicine, 2018, v. 215, p. 815-825-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/261929-
dc.description.abstract© 2018 Fu et al. T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6 fl/fl Foxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses. These mice exhibited enhanced immunity to influenza virus; moreover, Bcl6 fl/fl Foxp3Cre/Cre mice developed late-onset spontaneous autoimmune diseases, affecting the salivary glands with lymphocyte infiltration and antibody deposition. In a mouse experimental Sjögren's syndrome model, ablation of Bcl6 in T reg cells greatly enhanced disease development. Conversely, Bcl6 fl/fl Cd4Cre mice were protected in the model. Thus, our study indicates that Tfr cells control autoimmune diseases and can be targeted in infectious and autoimmune disease.-
dc.languageeng-
dc.publisherRockefeller University Press. The Journal's web site is located at http://www.jem.org-
dc.relation.ispartofThe Journal of Experimental Medicine-
dc.rightsThe Journal of Experimental Medicine. Copyright © Rockefeller University Press.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleDeficiency in T follicular regulatory cells promotes autoimmunity-
dc.typeArticle-
dc.identifier.emailLin, X: linxiang@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1084/jem.20170901-
dc.identifier.pmid29378778-
dc.identifier.pmcidPMC5839755-
dc.identifier.scopuseid_2-s2.0-85042878580-
dc.identifier.hkuros292468-
dc.identifier.volume215-
dc.identifier.spage815-
dc.identifier.epage825-
dc.identifier.isiWOS:000440812100010-
dc.publisher.placeUnited States-

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